285 research outputs found
sj-jpg-1-sph-10.1177_19417381211063847 – Supplemental material for Relative Validity and Reliability of Isometric Lower Extremity Strength Assessment in Older Adults by Using a Handheld Dynamometer
No full textSupplemental material, sj-jpg-1-sph-10.1177_19417381211063847 for Relative Validity and Reliability of Isometric Lower Extremity Strength Assessment in Older Adults by Using a Handheld Dynamometer by Pol Grootswagers, Anouk M. M. Vaes, Roland Hangelbroek, Michael Tieland, Luc J. C. van Loon and Lisette C. P. G. M. de Groot in Sports Health: A Multidisciplinary Approach</p
Reliability, construct validity and determinants of 6-minute walk distance in patients with asthma
No full textBackground: Despite the fact that the 6-minute walk test (6MWT) can provide insights in functional limitation i
Symptom-based clusters in people with ME/CFS: an illustration of clinical variety in a cross-sectional cohort
No full textBackgroundMyalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is a complex, heterogenous disease. It has been suggested that subgroups of people with ME/CFS exist, displaying a specific cluster of symptoms. Investigating symptom-based clusters may provide a better understanding of ME/CFS. Therefore, this study aimed to identify clusters in people with ME/CFS based on the frequency and severity of symptoms.MethodsMembers of the Dutch ME/CFS Foundation completed an online version of the DePaul Symptom Questionnaire version 2. Self-organizing maps (SOM) were used to generate symptom-based clusters using severity and frequency scores of the 79 measured symptoms. An extra dataset (n = 252) was used to assess the reproducibility of the symptom-based clusters.ResultsData of 337 participants were analyzed (82% female; median (IQR) age: 55 (44-63) years). 45 clusters were identified, of which 13 clusters included >= 10 patients. Fatigue and PEM were reported across all of the symptom-based clusters, but the clusters were defined by a distinct pattern of symptom severity and frequency, as well as differences in clinical characteristics. 11% of the patients could not be classified into one of the 13 largest clusters. Applying the trained SOM to validation sample, resulted in a similar symptom pattern compared the Dutch dataset.ConclusionThis study demonstrated that in ME/CFS there are subgroups of patients displaying a similar pattern of symptoms. These symptom-based clusters were confirmed in an independent ME/CFS sample. Classification of ME/CFS patients according to severity and symptom patterns might be useful to develop tailored treatment options
Short Physical Performance Battery: Response to pulmonary rehabilitation and MCIDs in patients with COPD
No full textBackground: The Short Physical Performance Battery (SPPB) is commonly used in patients with chroni
Analysis of retinal blood vessel diameters in patients with COPD undergoing a pulmonary rehabilitation program
No full textBackground: Regular exercise positively affects cardiovascular physiology, translating into the adequate capacity of microvascular blood vessels to dilate in response to acute bouts of exercise. However, this remains unstudied in patients with chronic obstructive pulmonary disease (COPD), who often suffer from cardiovascular comorbidity. Therefore, we studied acute changes in retinal blood vessel diameters in response to high-intensity exercise in patients with COPD. The effect of an exercise-based 8-week pulmonary rehabilitation (PR) program was evaluated. We consider changes in these retinal metrics as an indicator of microvascular reactivity. Methods: Demographics and clinical characteristics of 41 patients were collected at the start and end of the PR program. Patients performed a high-intensity exercise test on a cycle ergometer at the start and end of the PR program, during which we collected retinal images. Fundus images were taken immediately before and 0, 5, 10, 15, and 30 min after the ergometer test. Widths of retinal blood vessels, represented as Central Retinal Arteriolar and Venular Equivalents (CRAE and CRVE), were calculated. Results: Thirty patients with COPD completed the study protocol (57% males; mean age: 64 +/- 7 years; mean FEV1: 45 +/- 17%pred). We did not observe a change in retinal vessel widths following the ergometer test at the start of the PR program. This null result remained at the end of the 8-week PR program. Our observations did not alter when considering responders and non-responders to PR. Conclusion: Retinal blood vessel diameters of patients with COPD did not change following an exercise test on an ergometer. The exercise-based PR program of eight weeks did not counteract the blunted retinal microvascular response
Endothelial function in patients with COPD: an updated systematic review of studies using flow-mediated dilatation
No full textCardiovascular disease is a significant cause of morbidity and mortality in COPD. Endothelial dysfunction is suggested to be involved in cardiovascular disease pathogenesis, and multiple studies report endothelial dysfunction in COPD. This article summarized the current knowledge on endothelial function in COPD patients. Databases were screened until November 2022 for studies using ultrasound-based flow-mediated dilation in patients with stable COPD. Pooled effect sizes were calculated using random effects model. Meta-regression analyses assessed the effects of demographic and clinical variables. 34 studies were identified (1365 COPD patients; 617 controls). Pooled analysis demonstrated an impaired endothelial-dependent (−2.33%; 95%CI −3.30/-1.35; p < 0.001) and endothelial-independent dilation (−3.11%; 95%CI −5.14/-1.08; p = 0.003) in COPD patients when compared to non-COPD controls. Meta-regression identified that higher age, worse severity of airflow obstruction, and current smoking were significantly associated with impaired endothelial function. Studies evaluating the effects of pharmacological and non-pharmacological interventions on endothelial function in COPD patients demonstrated conflicting results.</p
Feasibility And Responsiveness Of Isokinetic Quadriceps Function In Patients With Chronic Obstructive Pulmonary Disease
No full textPeripheral muscle dysfunction has been associated with impaired health status and increased mortality in patients with chronic obstructive pulmonary disease (COPD). This highlights the importance of assessing and targeting peripheral muscle strength and endurance during pulmonary rehabilitation (PR). However, information regarding the feasibility and responsiveness of isokinetic quadriceps function following PR is limited. PURPOSE: To evaluate whether and to what extent the isokinetic evaluation of quadriceps muscle function meets the pre-defined test criteria in COPD patients; to determine the response to PR of isokinetic quadriceps muscle function. METHODS: A retrospective analysis of 2033 COPD patients (age: 65±9 years, 52% male, forced expiratory volume in 1st second: 49±22% predicted) following PR was performed. Individualized exercise training consisted of endurance, interval and strength straining and/or neuromuscular electrical stimulation. Isokinetic quadriceps function assessment consisted of 30 maximal extension-flexion contractions with a full range of motion at a fixed angular speed of 90°/s (computerized dynamometer). Criteria for a correct test performance were: completion of all 30 repetitions, peak torque reached within first five repetitions, and presence of work fatigue. Differences between pre and post PR were tested using paired t-tests. RESULTS: Pre PR, 27% of the patients did not fulfil one or more of the predefined test-criteria. In patients with a correct pre and post PR isokinetic test (n=989), isokinetic quadriceps peak torque (∆=8±12Nm) and total work (∆=229±234J) were responsive to PR (both p-values<0.001). There was no change in work fatigue index following PR. CONCLUSION: Based on the current test criteria, three in four patients with COPD performed the isokinetic quadriceps test correctly during a baseline PR assessment. PR has a beneficial effect on isokinetic quadriceps peak torque and total work, but not work fatigue index, in patients with COPD. The Self Natural Posture Exercise (SNPE), created in Korea, helps to improve chronic musculoskeletal pain and joint function. PURPOSE: This study aimed to verify the effect of SNPE on knee joint function, pain, and muscle tone in women in their 20s-40s with chronic knee joint pain. METHODS: Thirty one women (34.4±6.9 yrs, 161.2±4.7 cm, 55.8±8.6 kg, 21.5±3.0 kg/m²) with chronic knee joint pain for more than 3 months were divided into two groups; exercise (EG: n=19) and control (CG: n=12). EG underwent SNPE Lower Limb Conditioning Program 80 min per session, more than twice in a week, for 12 weeks. CG did not participate in any exercise programs. For EG, before and after the program, their knee joint function (Western Ontario and McMaster University Osteoarthritis Index: WOMAC), pain (Pressure pain threshold: PPT), andLung Foundation [5.1.18.232
Short Physical Performance Battery: Response to Pulmonary Rehabilitation and Minimal Important Difference Estimates in Patients With Chronic Obstructive Pulmonary Disease
No full textTo determine the response to a pulmonary rehabilitation (PR) program and minimal important differences (MIDs) for the Short Physical Performance Battery (SPPB) subtests and SPPB summary score in patients with chronic obstructive pulmonary disease (COPD).
Objective: To determine the response to a pulmonary rehabilitation (PR) program and minimal important differences (MIDs) for the Short Physical Performance Battery (SPPB) subtests and SPPB summary score in patients with chronic obstructive pulmonary disease (COPD). Design: Retrospective analysis using distribution-and anchor-based methods. Setting: PR center in the Netherlands including a comprehensive 40-session 8-week inpatient or 14-week outpatient program. Participants: A total of 632 patients with COPD (age, 658y; 50% male; forced expiratory volume in the first second=43% [interquartile range, 30%-60%] predicted). Interventions: Not applicable. Main Outcome Measure: Baseline and post-PR results of the SPPB, consisting of 3 balance standing tests, 4-meter gait speed (4MGS), and 5 -repetition sit-to-stand (5STS). The chosen anchors were the 6-Minute Walk Test and COPD Assessment Test. Patients were stratified according to their SPPB summary scores into low-performance, moderate-performance, and high-performance groups. Results: 5STS (Delta=-1.14 [-4.20 to-0.93]s) and SPPB summary score (Delta=1 [0-2] points) improved after PR in patients with COPD. In patients with a low performance at baseline, balance tandem and 4MGS significantly increased as well. Based on distribution-based calculations, the MID estimates ranged between 2.19 and 6.33 seconds for 5STS and 0.83 to 0.96 points for SPPB summary score. Conclusions: The 5STS and SPPB summary score are both responsive to PR in patients with COPD. The balance tandem test and 4MGS are only responsive to PR in patients with COPD with a low performance at baseline. Based on distribution-based calculations, an MID estimate of 1 point for the SPPB summary score is recommended in patients with COPD. Future research is needed to confirm MID estimates for SPPB in different centers.We thank Prof. Wim Derave (Ghent University) for his input and collaboration within the BASES Consortium, in the context of which the current article was written
Effects of Asthma on the Performance of Activities of Daily Living:A Retrospective Study
No full textThe study aim was to identify the most problematic self-reported activities of daily living (ADLs). In a retrospective study, 1935 problematic ADLs were reported by 538 clients with 95% experiencing two or more problematic ADLs. Problematic ADLs were assessed by occupational therapists using the Canadian Occupational Performance Measure with walking (67%), household activities (41%), and climbing the stairs (41%) identified as the most prevalent problematic ADLs. Significant but weak associations were found between clinical determinants (e.g. physical, psychosocial) and problematic ADLs. The wide variety of problematic ADLs and the absence of a strong association with clinical determinants emphasizes the need for using individualized interview-based performance measures in clients with asthma
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