133,577 research outputs found

    I ‘papeles de actor’ della Biblioteca Nacional de Madrid. Catalogo e studio

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    La expresión «papel de actor» se usaba para indicar la hoja que utilizaban los actores para aprender de memoria y ensayar un determinado rol dramático individual, o sea, sendas réplicas o parlamentos de cada actor. Como es sabido, antes de cada réplica se apuntaba la última palabra de la intervención anterior (lo que se llamaba pie y que se escribía en el centro de la columna para ser fácilmente reconocible), con el fin de que el actor supiera en qué momento del diálogo debía intervenir. Queda constancia de estos papeles también en el teatro medieval francés (los «rôles des acteurs»), en el teatro isabelino (las «actor’s parts») y, si bien con un nombre distinto, en la commedia dell’arte (las «parti scannate» —es decir, desglosadas—). En España se conservan 68 papeles de actor en la carpeta con signatura Ms. 14.612/8, objeto de este catálogo, y otros dos en la carpeta siguiente (sign. Ms. 14.612/9), [Vaccari, 2006b], ambas conservadas en la Biblioteca Nacional de España

    Rilettura di Pietro Vaccari

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    Si esamina l'opera del Vaccari e il concetto di costituzione medievale

    The News Media as Networked Political Actors: How the Italian Media are Reclaiming Political Ground by Harnessing Online Participation

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    Research on internet politics has found that digital media have contributed to a hybridization of the organizational practices of parties, movements and interest groups. Little attention, however, has been paid to how the news media employ online engagement tools to pursue political goals, as is the case when political parallelism is present. This study addresses this issue through an in-depth analysis of two Italian cases: the e-petition campaigns by the newspaper la Repubblica and the assemblage of a convergent media network to broadcast a protest rally organized by the television talk show host Michele Santoro. Online citizen engagement now constitutes a valuable political resource for journalists and news organizations that have historically been involved in the political battlefield rather than practicing objectivity and neutrality. However, these efforts are limited in their democratic potential to the extent that they constitute top-down leveraging of audience support by media elites rather than grassroots channels for citizens to set the agenda and voice their opinions. The relevance of these phenomena goes well beyond Italy, as parts of the media systems of most Western democracies are characterized by political parallelism

    Equilibrium and growth forms of sucrose crystals in the {h0l} zone. 1. Theoretical treatment of {101}-d form

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    Observed (h0l) growth forms of the sucrose crystal are compared with calculated ones, on the basis of attachment energy plots. Agreement is found for all forms only if a modification of character of the ( 101)-d face is taken into considation. Calculation of equilibrium and growth forms have been carried out using two potential foe dispersion and bond energy respectively. The same method is applied for studying the spiral growth shape on the (101) face and its field of validity is discussed: a low driving force values, the attachment energy at the steps is the relevant energy, determining the shape of spirals on (101) face of sucrose

    Definition of seismic and tsunami hazard scenarios by exploiting EU-India Grid e-infrastructures

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    Seismic hazard assessment can be performed following a neo-deterministic approach (NDSHA), which allows to give a realistic description of the seismic ground motion due to an earthquake of given distance and magnitude. The approach is based on modelling techniques that have been developed from a detailed knowledge of both the seismic source process and the propagation of seismic waves. This permits us to define a set of earthquake scenarios and to simulate the associated synthetic signals without having to wait for a strong event to occur. NDSHA can be applied at the regional scale, computing seismograms at the nodes of a grid with the desired spacing, or at the local scale, taking into account the source characteristics, the path and local geological and geotechnical conditions. Synthetic signals can be used as seismic input in subsequent engineering analyses aimed at the computation of the full non-linear seismic response of the structure or simply the earthquake damaging potential. The same approach can be applied to tsunami hazard assessment: for a specific coastal area one has to characterize the seismic sources and select the earthquake scenarios that can drive the hazard; afterward the associated synthetic tsunamigrams are computed using the modal method. Massive parametric tests, to explore the influence not only of deterministic source parameters and structural models but also of random properties of the same source model, enable realistic estimate of seismic hazard and their uncertainty. The use of the EU-India Grid infrastructure allows to conduct massive parametric tests for evaluating the uncertainties in the computed hazard maps. In the framework of cooperation project between three Italian partners (DMG, University of Trieste; ICTP SAND Group; CNR/IOM uos Democritos) and two Indian partners (ISR, Gujarat; CSIR C-MMACS, Bangalore) a system will be set up for the scenario-based characterization of the seismic and tsunami hazard, integrated with the e-infrastructures of the project EU-India Grid

    At the crossroads of polarity, proliferation and apoptosis : The use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression

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    Endocytosis is an important regulator of cell-cell signaling and endocytic trafficking has been increasingly implicated in control of tumor suppression. Recent insights from Drosophila indicate that impairment of multiple trafficking steps which lead to receptor degradation can cause tumor formation in epithelial organs. These tumors are characterized by sustained activation of a number of mitogenic signaling pathways, and by subversion of epithelial polarity and the apoptotic response. Cooperation between such alterations, as well as tumor-host interactions, is also observed. The recapitulation of several hallmarks of human cancers in fly tumors provides a framework to understand the role of defective endocytosis in cancer. © 2009 Federation of European Biochemical Societies

    The Drosophila Tumor Suppressor vps25 Prevents Nonautonomous Overproliferation by Regulating Notch Trafficking

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    SummaryCell-cell signaling coordinates proliferation of metazoan tissues during development, and its alteration can induce malignant transformation. Endocytosis regulates signaling by controlling the levels and activity of transmembrane receptors, both prior to and following ligand engagement. Here, we identify Vps25, a component of the ESCRT machinery that regulates endocytic sorting of signaling receptors, as an unconventional type of Drosophila tumor suppressor. vps25 mutant cells undergo autonomous neoplastic-like transformation, but they also stimulate nonautonomous cell proliferation. Endocytic trafficking defects in vps25 cells cause endosomal accumulation of the signaling receptor Notch and enhanced Notch signaling. Increased Notch activity leads to ectopic production of the mitogenic JAK-STAT pathway ligand Unpaired, which is secreted from mutant cells to induce overproliferation of the surrounding epithelium. Our data show that defects in endocytic sorting can both transform cells and, through heterotypic signaling, alter the behavior of neighboring wild-type tissue
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