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Asynchronous diastolic function in hypertensive patients with impaired left ventricular filling.
No full textFatty acid facts, Part I. Essential fatty acids as treatment for depression, or food for mood?
No full text
Biomarkers for Alzheimer's disease
No full textIt has been determined that patients
suffering from mild cognitive impairment
(MCI) may progress to Alzheimer’s
disease (AD), which offers a window
for therapeutic intervention to
slow or halt disease progression.
Thus, the detection of prodromal AD
is essential to initiate early treatment.
The key pathologic hallmark of AD
is amyloid β peptide 42 (Aβ42).
Probably because of its direct contact
with brain tissue, levels of Aβ42 in
combination with phosphorylated tau
determined in cerebrospinal fluid
(CSF) appear to be useful markers of
the disease. In addition, structural
and functional brain imaging with
magnetic resonance techniques and
metabolic imaging with positron
emission tomography have been
shown to provide useful disease markers.
These imaging markers include
diminished global brain and hippocampus
volume, grey matter loss in
the mediotemporal lobe, functional
neuronal disconnections and regional
hypometabolism. To date, the combination
of CSF Aβ42 and tau parameters
provide a sensitivity and a specificity
of > 80%. In this article we
summarize key aspects of diagnostic
markers for AD based on published
knowledge. We also dwell on the
potential usefulness of these markers
for treatment monitoring and in the
process of developing and evaluating
novel drugs
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