199,518 research outputs found
Ovarian endometriosis: from pathogenesis to surgical treatment
No full textPURPOSE OF REVIEW: This review analyzes the literature on ovarian endometrioma,
examining the controversies on pathogenesis, malignant transformation and
surgical therapy. RECENT FINDINGS: Recent literature reflects the necessity of
clearly defining the ethiologic and pathologic factors that determine the origin
of ovarian endometriosis and explain the increase in the condition with the
prospect of developing effective prevention therapy. The possibility that
ovarian endometriomas undergo malignant transformation is widely reported in the
literature. Recent studies underline the importance of detecting histological
differences in endometriosis (hyperplasia and atypia) and several studies of
molecular biology support the theory of genetic alterations interfering with
malignant transformation of ovarian endometriosis. SUMMARY: The surgical
approach must take into account all this information and, when the therapy is
conservative, complete excision of the disease must be laparoscopically
performed without affecting the healthy ovarian tissue
Endometrioma excision and ovarian reserve : a dangerous relation
No full textEndometrioma is one of the most frequent pathologies in gynecologic surgery. Laparoscopic cyst excision is considered the best treatment in terms of lower recurrence and improved fertility. However, it was recently questioned whether the excision of the endometrioma could decrease the function of the operated ovary and if it could affect the subsequent fertility. Even if a consistent amount of ovarian tissue is unintentionally removed together with the capsule of the cyst, resulting in does not show the follicular pattern observed in working ovaries. Currently, no definitive data clarify whether the damage to the ovarian reserve, observed in patient with endometrioma, is related to the surgical procedure, to the previous presence of the cyst, or both. Electrosurgial coagulation during hemostasis could play an important role in terms of damage to ovarian stroma and vascularization. Particular attention must be paid in presence of bilateral endometriotic cysts. In fact, an increase in premature ovarian failure rate was reported when both the ovaries are involved in surgery. Incase of assisted reproductive techniques, no clear evidence indicates which is the best approach for concomitant endometriotic cyst. On the base of these considerations endometriomas Should be treated only in case of pain, infertility, and in asymptomatic patients if the cyst diameter is greater than 4 c
Successful mestrual regularity and spontaneous pregnancies with a resveratrol-based multivitamin supplement in women with idiopathic premature ovarian insufficiency
No full textPremature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian activity before the age of 40 years and is characterized by menstrual disturbance, follicle stimulating hormone (FSH) concentration above 40 IU/l and infertility. In some patients the best option is to conceive spontaneously since many treatment strategies remain unsuccessful or involve eggs donation. In this case report series, we describe the effects of a resveratrol-based multivitamin supplement containing trans-resveratrol, folic acid, vitamin B6, B12 and D, in six women with poor prognosis of pregnancy due to POI and evaluate the achievement of desired conception.These women, aged less then 40 years, suffered from menstrual irregularities, anovulation and infertility. They all had normal karyotype, and no history of ovarian surgery, radiation exposure or chemotherapy. Blood test showed at least two values of FSH above 40 IU/l.Four out of six patients with POI conceived after 3-6 months of a resveratrol-based multivitamin supplement, ultimately giving birth to a full-term baby. Regular menstrual cycle was restored in all patients after two to four months the start of treatment. In conclusion the treatment with a resveratrol-based supplement improved menstrual regularity and suggest a useful potential of this supplementation in some cases of POI
Characterization of thin irradiated epitaxial silicon sensors for the CMS phase II pixel upgrade
No full textThe high-luminosity upgrade of the Large Hadron Collider foreseen for 2023 resulted on the decision to replace the tracker system of the CMS experiment. The innermost layer of the new pixel detector will experience fluences in the order of φeq ≈ 1016 cm−2 and a dose of ≈ 5 MGy after an integrated luminosity of 3000 fb−1. Several materials and designs are under investigation in order to build a detector that can withstand such high fluences. Thin planar silicon sensors are good candidates to achieve this goal since the degradation of the signal produced by traversing particles is less severe than for thicker devices. A study has been carried out in order to characterize highly irradiated planar epitaxial silicon sensors with an active thickness of 100 μm. The investigation includes pad diodes and strip detectors irradiated up to a fluence of φeq = 1.3 × 1016 cm−2, and 3 × 1015 cm−2, respectively.
The electrical properties of diodes have been characterized using laboratory measurements, while measurements have been carried out at the DESY II test beam facility to characterize the charge collection of the strip detectors. A beam telescope has been used to determine precisely the impact position of beam particles on the sensor. This allows the unbiased extraction of the charge deposited in the strip sensor and good identification of the noise. In this paper, the results obtained for p-bulk sensors are shown. The charge collection efficiency of the strip sensors is 90% at 1000 V after a fluence of φeq = 3 × 1015 cm−2. The irradiated diodes show charge multiplication effects. The impact of the threshold applied to a detector on its efficiency is also discussed
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