1,721,139 research outputs found
[Visceral pleura lipoma: a previously undescribed localization and review of the literature on pleural lipomas]
No full textPleural lipomas are rare, often asymptomatic tumours arising from the parietal pleura. Whereas radiographic signs of pleural lipomas are aspecific, computed tomography and magnetic resonance imaging permit accurate preoperative diagnosis. We describe the clinical-pathologic features of the first case of lipoma arising from the visceral pleura, accidentally discovered in a woman during removal of chest schwannoma. A review of literature concerning pleural lipomas is also presented
Apocrine epithelium of the breast: does it result from metaplasia?
No full textBenign and malignant breast lesions may show an apocrine epithelium considered to be the result of metaplasia. In an attempt to clarify the histogenesis of the breast apocrine epithelium we searched for the presence of apocrine cells or cells with apocrine differentiation during human breast development. We analysed 10 autopsy specimens of female breasts from fetuses between 28 and 40 weeks of gestational age and tissue from 6 normal breasts, obtained after breast reduction in nulliparous young women between 22 and 28 years of age. Formalin-fixed, paraffin-embedded sections were stained with haematoxylin-eosin, PAS-diastase and a monoclonal antibody (BRST-2) anti-GCDFP-15, which is a specific apocrine marker. A 40-week fetal breast was analysed by electron microscopy. No cells with histological and ultrastructural apocrine features were found in the ducts of fetal breasts. All fetal breasts showed some ducts with sparse GCDFP-15-immunoreactive cells; the number of these cells increased with gestational age. PAS-diastase was negative. No cells with apocrine morphology were found in ducts and lobules of normal adult breasts. Scattered GCDFP-15-positive luminal epithelial cells and rare PAS-diastase-positive cells were observed in some lobules of all adult breasts. Cells with biochemical characteristics (GCDFP-15 expression) of apocrine differentiation are evident during human fetal breast development and persist in adult mammary glands. Unknown stimuli may induce these cells to take on an apocrine morphology. Apocrine epithelium of the breast may be a normal process of differentiation rather than metaplasia. We suggest the term "apocrine differentiation precursor cells" for GCDFP-15-positive breast epithelial cells with no apocrine morphology
Le carcinoma canalicolaires in situ du sein : aspect anathomoclinique et considerations therapeutiques
No full textSpectrum of GCDFP-15 expression in human fetal and adult normal tissues.
No full textGCDFP-15, a glycoprotein identified in the cyst fluid of cystic breast disease, is considered to be a marker of apocrine differentiation. Studies on GCDFP-15 localization in adult normal tissues are lacking, and no information on GCDFP-15 expression during fetal development has been reported. We investigated GCDFP-15 expression in a large series of formalin-fixed, paraffin-embedded normal human adult and fetal tissues using the monoclonal antibody BRST-2. In normal adult tissues GCDFP-15 expression was found in all apocrine, lacrimal, ceruminous and Moll's glands and in numerous serous cells of the submandibular, sublingual and minor salivary glands. The serous cells of nasal and bronchial glands were also positive; parotid and laryngeal glands showed rare immunoreactive cells. GCDFP-15-positive cells were observed in all cutaneous eccrine glands from different body sites. In fetal tissues immunoreactivity was observed in numerous acinous cells of all tracheal, bronchial and submandibular salivary glands. GCDFP-15 positivity was identified in numerous cells of all axillary sweat glands and in rare cells of some sweat glands of the thorax, abdomen, back, leg and arm. In both apocrine and nonapocrine glands GCDFP-15 was always localized in the secretory component. These data suggest that GCDFP-15 is a glandular differentiation marker associated with apocrine secretion; that it is expressed in glands that have phylogenetic origins in common with apocrine glands (submandibular salivary and submucosal bronchial glands); and that eccrine cutaneous glands express GCDFP-15 and thus might be referred to as mixed apocrine-eccrine glands. GCDFP-15 is expressed during fetal development and may represent a common marker of embryologically linked glandular structures
Paraneoplastic alopecia associated with hepatocellular carcinoma in a cat
No full textA 15-year-old spayed female domestic shorthair cat presented with alopecia associated with hepatocellular carcinoma. Clinical signs, which had commenced 6 months previously, included loss of appetite, loss of weight, and depression. As reported by the owner, the cat developed alopecia a week before referral. The hair loss was localized to the ventral aspect of the thorax and abdomen, medial aspect of front and hind limbs, and ventral aspect of the tail, and was associated with histological features consistent with paraneoplastic alopecia. At necropsy, multiple hepatic nodules were observed, and subsequent histopathological investigation showed cords and sheets of hepatocyte-like neoplastic cells positive for the hepatocyte marker (Hep Par 1), thereby demonstrating the hepatocellular origin of the tumour, which was diagnosed as a hepatocellular carcinoma. This is the first report of feline paraneoplastic alopecia associated with hepatocellular carcinoma confirmed by the Hep Par 1 marker
New observations on a case of treponematosis (venereal syphilis?) in an Italian mummy of the 16th century
No full textA special case of bilateral ovarian metastases in a woman with papillary carcinoma of the thyroid
No full textPapillary thyroid carcinoma is a slow growing tumor with low metastatic
potential. The most frequent sites of distant metastases are lung and bone; less
frequent sites are brain, liver, kidney, and skin. Ovarian metastases from
papillary thyroid carcinoma are exceptional. We describe a case of bilateral
ovarian metastases from a papillary thyroid carcinoma associated with autoimmune
thyroiditis in a 38-year-old woman who underwent thyroidectomy and cervical
lymph-node dissection 7 years before, followed by 948 mCi of 131I. A primary
ovarian cancer could be excluded by the typical pathological aspects of a
papillary thyroid carcinoma in a context of an aggressive form of thyroid cancer.
On the other hand, the clinical history and the absence of normal thyroid
epithelium and teratomatous components could exclude a papillary thyroid
carcinoma arising in struma ovarii. This is a singular case of papillary thyroid
carcinoma metastasizing to the ovary, combined with an autoimmune thyroiditis
Restoration of fecal continence with chronic electrostimulation of gracilis muscle 17 years after a Pickrell's operation
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