1,721,031 research outputs found
CAMM techniques for the prediction of the mechanical properties of tendons and ligaments nanostructures
No full textResponse to letter to the editor: On the calculation of the binding force between decorin and collagen
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Mechanical properties of physiological and pathological models of collagen peptides investigated via steered molecular dynamics simulations
No full textCharacterization of mechanical properties of ECM in nanostructures of tendons and ligaments
No full textTransmembrane adhesion protein and RGD-grafted biomaterial: a molecular approach to estimate cell adhesion strength.
No full textIntegrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems
Full text linkOrgans-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced in vitro tools able to replicate essential functions of human organs. Owing to their unprecedented ability to recapitulate key features of the native cellular environments, they represent promising tools for tissue engineering and drug screening applications. The achievement of proper functionalities within OoC is crucial; to this purpose, several parameters (e.g., chemical, physical) need to be assessed. Currently, most approaches rely on off-chip analysis and imaging techniques. However, the urgent demand for continuous, noninvasive, and real-time monitoring of tissue constructs requires the direct integration of biosensors. In this review, we focus on recent strategies to miniaturize and embed biosensing systems into organs-on-chip platforms. Biosensors for monitoring biological models with metabolic activities, models with tissue barrier functions, as well as models with electromechanical properties will be described and critically evaluated. In addition, multisensor integration within multiorgan platforms will be further reviewed and discussed
Molecular design of alfavbeta3 integrin links to RGD grafted polyethylene provides the estimation of endotelial cell adhesion force
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