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LA SOMMINISTRAZIONE DEI COFATTORI PROPIONIL – L – CARNITINA, COENZIMA Q10, NICOTINAMMIDE, RIBOFLAVINA E ACIDO PANTOTENICO INDUCE NEL RATTO UN AUMENTATO UTILIZZO DEI SUBSTRATI ENERGETICI
No full textDoes early stage diabetes induce an adaptation of contractile machinery in female rats
No full textSeveral evidences have suggested that there is a gender bias in the progression of diabetic cardiomyopathy. Indeed, premeopausal women frequently have a shorter risk of cardiovascular diseases than age-matched men and postmenopausal women.
We investigated in female diabetic rats, whether altered myocardial function was related to changes in actomyosin interactions and if these modifications were attributable to a possible sarcomere rearrangement.
Experiments were carried out on papillary muscles from diabetic female Wistar and age-matched control rats. Isometric and isotonic parameters, introduced into Huxley’s model, allowed to calculate mechanics, kinetics and energetics of myosin crossbridges. Sarcomere length was measured on TEM micrographs.
Surprisingly, higher crossbridges number and lower unitary force were observed in diabetic rats. Histological and ultrastructural studies revealed fewer and longer sarcomeres in diabetic animals. Although the early signs of diabetic cardiomyopathy were well expressed, these findings suggested that in early stage of diabetes, female rats would show a compensatory mechanism to ensure an adequate stroke volume and a preserved cardiac performance
Long-term voluntary ethanol consumption induces impairment of the mechanical performance in the papillary muscle of Sardinian alcohol-preferring rats
Full text linkhe effects of chronic (26 weeks) ethanol consumption on cardiac muscle contractility in Sardinian alcohol-preferring drinkers (sP-D) and Sardinian alcohol-preferring naive (sP-N) rats were investigated. Experiments were carried out 1 week after ethanol administration ceased. Length-tension and force-frequency responses in left ventricular papillary muscles from both sP-D and sP-N rats were recorded in vitro. Papillary muscles were gradually stretched in steps of 5% of the reference (initial) length (L-r) from 100 to 130% L-r. In sP-D rats, length-tension relationships showed a significant reduction in active tension: at optimal length for maximum active tension (130% L-r), the developed force value (1.38 +/- 0.36 mN/mg, dry tissue) was 54% lower than that found in sP-N rats (3.16 +/- 0.6 mN/mg, dry tissue). In sP-D papillary muscles, a decrease in contractile behaviour was also observed in force-frequency responses (0.03-120 pulse/min), when compared with sP-N rats; developed force was found to be reduced by about 2.5 times. These results indicate that long-term ethanol consumption impairs the mechanical performance of sP papillary muscle, inducing a negative inotropic effect
Il dotto eiaculatore umano e la sua funzione sfinterica e antireflusso nella via spermatica
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Cardioreparative effect of a coformulation of CoQ10, propionyl-L-carnitine and omega-3 fatty acids, on BIO TO-2 cardiomyopathic Syrian hamsters
No full textAutomatic classification of mammographic masses by ROI cross sectional intensity profile analysis
No full textBreast cancer represents the leading cause of fatality among cancers for women and there is still no known way of preventing this pathology. Computer aided analysis systems could be very helpful to improve both the sensitivity and the specificity. In this paper, a computer aided diagnosis system for malignant/benign masses classification of ROI in mammograms based on wavelet transform decomposition and artificial neural network (ANN) classifier is shown. The main novelty of the system is to consider only small 1D signals crossing the abnormal region, allowing to drastically reduce the amount of data to be processed. An experimental analysis performed on a set of images from DDSM database has shown the effectiveness of the proposed method
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