1,721,155 research outputs found
The Spectrum of Neuroendocrine Neoplasia: A Practical Approach to Diagnosis, Classification and Therapy by Sylvia L. Asa, Stefano La Rosa, Ozgur Mete
No full textClinico-pathologic, histophenotypic, molecular and prognostic characterization of small bowel carcinomas associated with celiac disease or Chron’s disease.
Full text linkNon-familial small bowel carcinomas are relatively rare and have a poor prognosis. Celiac disease and Crohn’s disease are predisposing conditions for small bowel carcinoma development. In this study, small bowel carcinomas associated with celiac disease (n=26), small bowel carcinomas associated with Crohn’s disease (n=25) and sporadic small bowel carcinomas (n=25) were systematically compared. We found that in patients undergoing surgery for small bowel carcinomas the underlying immune-mediated disorder represents a stage-independent prognostic factor. Despite their common origin in a chronically inflamed mucosa, celiac disease-associated and Crohn’s disease-associated small bowel carcinomas differ substantially in tumor cell phenotype, tumor-infiltrating lymphocyte density, microsatellite instability status, Wnt pathway activation, as well as mucosal precursor lesions. Moreover, Epstein-Barr virus-positive carcinomas may occur in the ileum of Crohn’s disease patients and are characterised by increased tumor-infiltrating lymphocytes, either with lymphoepithelioma-like or with a more conventional glandular histology
Histogenesis and natural history of gut neuroendocrine tumors: present status
No full textImportant progress has been made during the last decade in the histopathologic characterization and overall prognostic evaluation of gut neuroendocrine tumors. However, some issues like tumor histogenesis, typing, functional characterization, and preferred site of origin deserve further clarification. This is a survey of the present status of the matter outlining some of the open points. In particular, careful comparison of normal gut endocrine cell types with related endocrine tumors so far identified shows an unexplained lack of neoplasms involving upper small intestine cells like secretin, cholecystokinin, motilin, and GIP cells, as well as the equally unexplained concentration of serotonin EC cell tumors in the ileum and appendix or of somatostatin cell tumors in the duodenal papillary region, despite their wide distribution in the normal gut, not to mention gastrinomas arising in the pancreas, normally devoid of gastrin cells. Special functional (e.g., achlorhydria-driven hypergastrinemia) or pathologic (as chronic inflammation) conditions may locally influence the proliferative and differentiation state of the endocrine cells thus promoting tumor growth. Tumor histologic structure, differentiation level, and proliferative index as well as gastrointestinal wall barriers to tumor diffusion may account for most prognostic parameters, with considerable changes, however, according to the tumor type and site. Thus, further work is needed to develop tumor- and site-adjusted prognostic parameters
Pratiche e immagini della guerra tra cristianità e islam nell'alto Medioevo spagnolo (secoli X-XI)
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Nonfunctioning pancreatic neuroendocrine neoplasms (including PP-producing and calcitonin-producing tumors)
No full textA charming molecular profile in the wrong tissue: the pathologist in the era of molecular diagnostics in the gastrointestinal tract
No full textthe pathologist in the era of molecular diagnostics in the gastrointestinal trac
Very early onset inflammatory bowel diseases: Is it the time to share and define a histopathological reporting scheme?
No full textMismatch repair deficiency in multifocal gastric epithelial neoplasia and non-dysplastic glands: Harbinger of Lynch syndrome in an autoimmune gastritis patient
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