1,720,979 research outputs found
Analisi attraverso scansione AFM degli effetti superficiali degli irriganti canalari (NaOCl e EDTA) sui Protaper
No full textObjective. The aim of this study was to investigate, by using atomic force microscopy (AFM), the
effects of sodium hypochlorite (NaOCl) and EDTA on the surface characteristics of ProTaper
rotary nickel titanium instruments.
Study design. A total of 20 ProTaper nickel-titanium files ( S1,S2,F1,F2), were divided in 5
groups: no immersion, immersion in 5.25% NaOCl for 5 or 10 minutes and immersion in 17%
EDTA gel for 5 or 10 minutes. Twenty areas of the surface along 3-mm section at the tip of the
files (perfect squares of 1μm x 1 μm) were analyzed by atomic force microscopy (AFM Perception,
Assing, Italy) operating in contact mode under ambient condition. Three-dimensional images (400
× 400 lines) were processed by Gwiddion software and the roughness average (Ra) and the rootmean-
square value (Rms) of the scanned surface profiles were recorded. The data were analyzed
using Student t Test.
Results. Mean Rms and Ra values for NaClO and EDTA measurements were statistically higher
than the measurements on new files ( P < 0.05).
Conclusion. The AFM results show that NaOCl and EDTA significantly increased the surface
roughness of Protaper files
Endodontic retreatment of maxillary first molar: The importance of the fourth canal
No full textAbstractAimThe targets of the endodontic therapy are damaged tissue and bacteria removal from the canals and dentinal tubules and the prevention of recontamination after the treatment.IntroductionCorrect endodontic treatment has to follow several parameters: proper diagnosis, isolation of operating field, full chemo-mechanical preparation of the complex endodontic system, three-dimensional obturation of the root canals, post endodontic restoration. Respecting all these parameters short and long term success can be achieved.Materials and methodsIn this article an orthograde retreatment of maxillary first molar has been described, which showed at pre-operative X-ray, an incongruous endodontic therapy, the failed finding of the fourth canal and the presence of periapical lesions.DiscussionA high percentage of failures is due to missed root canals and therefore not cleansed, shaped and it is essential to use modern technologies to achieve safe and reproducible results.ConclusionsThe endodontic retreatment of this right maxillary first molar was performed with the proper protocols and sophisticated tools, with which we can achieve success in the short- and long-term treatments
Inflammaging, Epigenetic Damage, Mitochondrial Dysfunctions, and Macrophage Alterations are the Main Missing Pieces in the Complex Mosaic of Stem Cell Physiology
Full text link: Aging is frequently associated with a progressive increase in chronic low-grade inflammation, known as "inflammaging". Numerous studies have shown that inflammaging is closely linked to the development of several age-related diseases. However, the underlying mechanism and its causal role are still not fully understood despite this association. In the complex context of aging, mesenchymal stem cells (MSCs) undergo changes in behavior and functionality. This narrative topical review examines the recent advances in aging research, specifically focusing on the role of inflammaging and related mechanisms that contribute to age-related chronic diseases. The authors critically investigated whether and how inflammaging, epigenetic damage, mitochondrial changes, and macrophage alterations may influence stem cell behavior, highlighting the interplay between these factors and their potential therapeutic implications. By elucidating the mechanisms underlying these processes, we can gain valuable insights into the maintenance and regeneration of stem cell populations, providing the basis for novel therapeutic strategies targeting age-related decline and disease progression
Deciduous dentition: anatomical study by m-CT
No full textEndodontics is the branch of deciduous teeth pediatric dentistry that deals with the treatment of the root canal system. The goal of therapy is to maintain as long as possible the element in the dental arch to prevent alterations of orthognathodontic, infectious, and functional history and eruptive sequence. Although manual instrumentation has been widely used and still preferred by some practitioners, has limitations that affect the actual ability to clean the channel, the ability to create steps, perforations, dentinal plugs and fractures of the instrument. On the other hand, the disadvantages are the high cost of the instruments in nickel-titanium, which must be frequently replaced, and the risk of compromising the stability of the tooth due to an excessive consumption of dentinal tissue. The use of computed microtomography (μCT) of extracted elements has a considerable advantage in the study of dental hard tissues. The purpose of this study was to analyze the anatomy of the endodontic system of the elements deciduous
Introduzione alle cellule staminali e all’endodonzia rigenerativa
No full textThe practice of dentistry is likely to be revolutionized by biological therapies
based on growth and differentiation factors, scaffold materials and
stem cells. This approach, called regenerative dentistry, is becoming a
promising field of research which aims to replace, repair and regenerate
dental tissues in order to restore the biological function that has
been halted or compromised by injury or disease. The present review
represent an introduction to stem cell biology, with special emphasis
on stem cells derived from dental tissues. Since there has been a burst
of interest, even at mass media level, for the potential possibility to built
teeth in the laboratories, more patients are becoming aware of new
treatment options, like those based on stem cells, as potentially available
in the clinical practice. Therefore, the main objective of this article is to
make the endodontic practitioners able to answer patient’s questions
on stem cells, their properties and their potential use in regenerative
endodontics and medicine
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