1,028 research outputs found
Sbaglia l'uomo, fin tanto che aspira
No full textL'inarrestabile cammino verso il progresso dell'umanità, sempre in precario equilibrio tra utopia e hybris, è l'oggetto dell'indagine di Eleonora Chiesa nel suo "libro-performance" "More"
The design in the sustainable management of stormwater: the case study of the Province of Varese (Italy)
No full text“but I am also influenced by no such thing”-The Radical Pietist and Theological Author Johanna Eleonora Petersen
No full textJohanna Eleonora von und zu Merlau, verheiratete Petersen, von jeher tief gläubig, veränderte die religiöse Welt des 17. Jahrhunderts. Sie bekannte sich zur Bewegung des Pietismus und vertrat radikale Ansichten, nicht nur im privaten Kreis, sondern als anerkannte und heftig kritisierte theologische Autorin. Ihrem Werk ist eine Studie gewidmet, in der neue Forschungsergebnisse vorgestellt und Leben und Werk dieser bedeutenden Autorin in zeitgenössische Diskurse eingebunden werden.The deeply devout Johanna Eleonora Petersen, whose maiden name was „von und zu Merlau,” changed the religious world of the seventeenth century. She avowed herself to Pietism and held radical views, not only in private but also as an acknowledged and sharply criticized theological author. This study attends to her work. It presents new research results and weaves the life and work of this important author into contemporary discourses
La notion de défectuosité du produit dans les jurisprudences des pays européens
No full textThis work analyses the notion of defective product originally developed by US Courts, then ambiguously defined by the European directive n. 374 of 1985 and differently interpreted and applied by the respective domestic Courts. In particular, some European jurisdictions apply the risk / utility test introduced by the US Courts for design defects cases, although this test is not mentioned by the European Directive. The author, having highlighted the inconsistences of the risk / utility test, proposes an alternative model of classification of defective products according to the elements actually used by judges in order to allocate the liability, as emerging from the text of their decisions. This classification leads to held the manufacturer strictly liable not only for manufacturing defects, but also for those design defects which he was aware of (as in some cases of defective vaccine).Cette étude examine la notion de défectuosité du produit initialement élaborée par les Cours américaines, définie de manière ambigüe par le législateur européen avec la directive n° 374 de 1985, puis différemment interprétée et appliquée par les Cours respectives des pays membres. Notamment certains systèmes juridiques européens appliquent le risk/ utility test élaboré par les Cours américaines pour les cas de défaut de conception du produit, bien que ce test ne soit pas mentionné par la directive européenne. L’auteur, après avoir mis en évidence les incongruences du risk/ utility test, propose un modèle alternatif de classification des cas de produits défectueux sur la base des critères d’imputation de la responsabilité qui sont concrètement utilisés par les juges et tels qu’imagés dans les textes de leurs décisions. Cette reconstruction amène à imputer au fabricant une responsabilité objective non seulement pour les cas de défaut de production, mais aussi pour les cas de défaut de conception dont il était averti (tel que certain cas de vaccin défectueux).Rajneri Karageorgevitch Eleonora. La notion de défectuosité du produit dans les jurisprudences des pays européens. In: Revue internationale de droit comparé. Vol. 67 N°1,2015. pp. 185-205
TO THE JUBILEE OF PROFESSOR STEPANOVA ELEONORA FEDOROVNA
No full textThe article is devoted to the anniversary of Professor Eleonora Fedorovna Stepanova – a bright representative of the Russian intelligentsia: a talented lecturer, an inventor, an author of numerous books, an internationally recognized scholar
Author response
No full textHebb's idea of a cell assembly as the fundamental unit of neural information processing has dominated neuroscience like no other theoretical concept within the past 60 years. A range of different physiological phenomena, from precisely synchronized spiking to broadly simultaneous rate increases, has been subsumed under this term. Yet progress in this area is hampered by the lack of statistical tools that would enable to extract assemblies with arbitrary constellations of time lags, and at multiple temporal scales, partly due to the severe computational burden. Here we present such a unifying methodological and conceptual framework which detects assembly structure at many different time scales, levels of precision, and with arbitrary internal organization. Applying this methodology to multiple single unit recordings from various cortical areas, we find that there is no universal cortical coding scheme, but that assembly structure and precision significantly depends on the brain area recorded and ongoing task demands
Rescate y conservación del Acervo Histórico del Palacio de Minería: Informe de las labores de conservación preventiva e intervenciones menores en material Bibliohemerográfico y actividades en apoyo al Acervo Histórico : octubre 2011 - febrero 2012
No full textEl presente informe tiene como finalidad dar constancia de los trabajos realizados en el Acervo Histórico del Palacio de Minería, por los restauradores Roderick Palacios, Isabel Ritter y Eleonora Cruz, pasantes de la Licenciatura en Restauración de Bienes Culturales como prestación de su servicio social.</p
Tra quadro e cornice
No full textThe author presents a reconstruction of the experience she had in Pontedera when she saw some performances of the Workcenter of Jerzy Grotowski and Thomas Richards and took part to some works of the group. The text is composed by two parts: a descriptive and a theoretical one. In the first part, that she called “paintings”, the author tries to present his memory of what she saw and of what happened. Two plays are described, namely L’heure fugitive and The Underground, from the Focused Research Team in Art as a Vehicle, directed by Thomas Richards. After that, there is a description of open rehearsal of Thomas Richards’ group, in which the actors did singing exercises. The last activity was instead a singing session with Mario Biagini and his team, where the author and her colleagues participated actively. In the theoretical part, the author exposes her reflections concerning performances and other experiences, by focusing in particular on their meaning as well as on their major points of interest
Design and synthesis of new coumarin hybrids with antiproliferative activity against neuroblastoma cells
No full textIn order to identify new agents with anticancer activity, our research project is aimed at the design and synthesis of new hybrid molecules using the fragment-based strategy.
For this purpose, two naturally occurring scaffolds with antiproliferative and antioxidant properties, respectively, were combined. We synthesized new hydrazones of coumarin-3-carboxylic acid with aryloxy-substituted vanillin or isovanillin, obtaining a small library (16 compounds, throughout multistep synthesis.
The antioxidant properties of the compounds, were evaluated on the basis of their chemical structure by using in vitro DPPH colorimetric assay 1. Furthermore, their anticancer activity was tested by MTT assay in a neuroblastoma (NB) cell line (HTLA-230) and in an etoposide-resistant one (HTLA-ER), selected by HTLA-230 2. Both the NB cell lines were treated for 48 h with increasing concentrations (2.5-30 μM) of the compounds. Most of the IC50 values showed an anticancer effect at low micromolar range (8-25 μM) with a similar trend in both NB cell populations.
Based on these results, it is possible to highlight some structure-activity-relationships useful for designing new compounds with better antiproliferative activity.
At the same time, further biological studies will be undertaken to identify the mechanisms of action of these new promising anticancer compounds.
(1) Brand-Williams, W.; Cuvelier, M. E.; Berset, C. Use of a Free Radical Method to Evaluate Antioxidant Activity. LWT - Food Sci. Technol. 1995, 28 (1), 25–30. https://doi.org/10.1016/S0023-6438(95)80008-5.
(2) Colla, R.; Izzotti, A.; De Ciucis, C.; Fenoglio, D.; Ravera, S.; Speciale, A.; Ricciarelli, R.; Furfaro, A. L.; Pulliero, A.; Passalacqua, M.; Traverso, N.; Pronzato, M. A.; Domenicotti, C.; Marengo, B. Glutathione- Mediated Antioxidant Response and Aerobic Metabolism: Two Crucial Factors Involved in Determining the Multi-Drug Resistance of High-Risk Neuroblastoma. Oncotarget 2016, 7 (43), 70715–70737.
https://doi.org/10.18632/oncotarget.12209
New coumarin hybrids with antiproliferative activity against a neuroblastoma cell line
No full textIn order to identify new agents endowed with antiproliferative activity, our research project aims to design and synthesize new hybrid molecules using the fragment-based strategy. For this purpose, two naturally occurring scaffolds with antiproliferative and antioxidant properties were combined hoping for a synergistic effect. We decided to synthesize new hydrazones of coumarin-3-carboxylic acid with phenoxy- or benzyloxy-substituted vanillin or isovanillin, obtaining a small library of compounds throughout multistep
synthesis in good yields.
To evaluate the antioxidant properties depending on chemical structure, all the compounds were tested
through the DPPH colourimetric assay. Furthermore, the compounds were tested for their
antiproliferative activity both on a neuroblastoma cell line (HTLA-230) and an etoposide-resistant one
(HTLA-230-ER)1.
The IC50 values were determined by MTT assay and results showed a low μM activity for some of these
compounds. It is interesting to note that in most cases, the activity is similar both against the normal
neuroblastoma cell line as well as on the resistant one. Additional tests on compounds with the best
antiproliferative activity are being carried out to evaluate the antioxidant activity in cellular assays (inhibition of reactive oxygen species (ROS) production).
Overall, the results will allow us to highlight the importance of the antioxidant activity of the new
compounds and further studies will clarify the presence of possible additional mechanisms of action
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