1,721,183 research outputs found
Polymeric nanocapsules for pharmaceutical applications
Full text linkPolymeric nanoparticles can be used for drug release in cancer therapy. Nanoparticles can be divided into nanospheres and nanocapsules, accordingly to their structure. Nanospheres are constituted by just the polymer, while nanocapsules have an inner liquid core surrounded by a polymer layer. Drug can be incapsulated inside these structures. Amphiphilic copolymer can be used for this purpose because they allow to have an organic inner core and an hydrophilic external shell. A novel copolymer from cyanoacrylates family have been synthesized, with an hydrophilic monomer and an idrophobic monomer in a ratio 1:4. This copolymer has been characterized in terms of its thermal behavior and crystalline characteristics and of its water degradability. Confined impinging jets mixers have been used to produce nanocapsules and results are compared with the ones obtained with nanospheres. CIJMs allows to obtained nanocapsules with controlled size thank to the high mixing efficiency inside the mixing chamber. Drug release tests have been performed and show that the release from nanocapsules is slower than from nanspheres. Moreover, drug release in the first hours of release depends on a diffusive mechanism since the polymer has not been destroyed ye
Nuove misure urbane. Una ricerca progettuale per Tor Bella Monaca -New urban measurements. A design research project for Tor Bella Monaca.
No full textDistance becomes a problem in the regeneration of neighbourhoods built in the second half of the twentieth century both from the viewpoint of form and the use of spaces, where the measurements expand in the open intervals and in the shape of the built structures. The hypothesis formulated in the design research project on Tor Bella Monaca is that even those parts of the city built in the second half of the twentieth century can become consolidated, starting from their measurements and rhythms and from the broad intervals that created the basic design, but which must be transformed at the same time to respond to contemporary uses and needs. Remeasurement of the space is therefore a task of interpretation for architectural designers in order to recognise the intrinsic qualities of marginal urban housing designs to support redevelopment strategies which hinge on densification, subtraction, addition and infrastructures for the urban fabric, without trivialising the reconstitution of the proximity and the contact space in a historically anachronistic perspective
Saul Steinberg a Milano
No full textL'articolo ricostruisce gli anni della formazione di Saul Steinberg alla Facoltà di Architettura del Politecnico di Milano, la sua visione dell'architettura, della città di Milano, dell'Italia,riassumendo i contenuti della mostra, curata da I. Valente, L. Spinelli, C. Cozza, tenuta presso la Scuola di Architettura e Società
Descrizione dei caratteri morfologici del tessuto urbano milanese
No full textNumero monografico: "Milano verso il Piano. Descrizioni e interpretazioni del territorio milanese"
La rigenerazione dei tessuti urbani marginali: costruire un percorso di riocerca tramite sperimentazioni progettuali
No full textLa ricerca progettuale che il testo introduce affronta la questione del grado di trasformabilità dei tessuti, della loro demolizione, manutenzione, costruzione, consolidamento. Si intende argometare la possibilità di operare tramite una pratica di rigenerazione del margine urbano aperta e integrabile, sorretta da una consapevole e orientata descrizine del contesto a cui ancorare puntuali scritture progettuali
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