1,478 research outputs found

    Metamorfosi e peregrinazioni di Io. Dalla pittura vascolare alla tragedia, e ritorno

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    L'evoluzione iconografica della rappresentazione di Io nella pittura vascolare, a seguito della pubblicazione del "Prometeo incatenato" di Eschil

    Due note alla Vita Persi del Vind. 3094 (XV sec.)

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    Il presente articolo esamina una testimonianza finora trascurata della tradizione biografica su Persio, la Vita Persi conservata nel Wien, Österreichische Nationalbibliothek (ÖNB), Cod. 3094. Questo manoscritto di origine tedesca, redatto tra il 1493 e il 1496, contiene al f. 214v una Vita Persi di epoca umanistica, scritta a Worms l’1 novembre del 1494. Sebbene l’autore della biografia resti ignoto, il testo si colloca chiaramente nell’alveo della tradizione derivata dalla Vita attribuita al grammatico Valerio Probo di Beirut (I sec. d.C.), pur presentando innesti da fonti non sempre identificabili. Di tale Vita Persi Vindobonensis, della quale si fornisce una trascrizione integrale quanto più possibile rispettosa dell’ortografia del manoscritto e suddivisa in undici paragrafi per agevolarne la lettura, vengono presi in esame due specifici passi, estrapolati dalle sezioni relative alla narrazione degli anni di formazione di Persio (§ 3) e all’elenco delle sue opere giovanili (§ 8), dai quali è possibile ricavare elementi utili per tentare di dirimere due diverse problematiche di carattere esegetico – testuale (aliquatenus e vescio) presenti nell’antica Vita Persi attribuita a Valerio Probo

    Enhancing the Robustness of System on FPGA by Routing Isolation

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    Due to their high performance and flexibility, FPGAs have become an attractive solution for space applications. However, SRAM-based FPGAs are particularly sensitive to radiation-induced Single Event Effects that may lead to configuration memory corruption. We propose a methodology for enhancing the reliability of redundant design implemented on FPGAs. Statically analyzing the implementation of the circuit to identify and reduce the single points of failure of redundant systems, we can increase the system's robustness by controlling the placement phase

    A Spatial Information System (SIS) for the Architectural and Cultural Heritage of Sardinia (Italy)

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    The paper presents a spatial information system (SIS) developed in the research project, “Tecniche murarie tradizionali: conoscenza per la conservazione ed il miglioramento prestazionale” (Traditional building techniques: from knowledge to conservation and performance improvement), with the aim of archiving and managing the data derived from the project. The research project has the purpose of studying the building techniques of the 13th–18th centuries in the Sardinia region (Italy) for their knowledge, conservation, and promotion. The research is founded on a multidisciplinary approach involving several specialists integrating their expertise and providing their input to the knowledge of the dimensional, technical constructive, mensiochronological, materials, physical-mechanical, and energy performance features. This multidisciplinary approach is used to define the peculiarities and behavior of the examined structures, including their performance levels, and then direct the interventions toward innovative, mindful, and ethically correct solutions. The management of the huge amount of data produced during the research required the building of a SIS composed of a geodatabase connected to a GIS and aWebGIS through aWeb Map Service (WMS). The entire infrastructure is developed and implemented using open source software components, and will make the research data available to the scientific and professional communities, both for further development and for technical uses. As of today, we surveyed and archived more than 500 buildings belonging to the Sardinia region architectural heritage, and classified them into four main macro categories: defensive architectures, religious architectures, residential architectures, and industrial architectures

    Integrating bim and gis data to support the management of large building stocks

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    The survey phase is an essential prerequisite for effective management and improvement of existing buildings. The low accessibility of information regarding the design and construction phases and the current state of the buildings, are the main causes of inefficient actions on existing buildings. The lack of “As Built” documentation (building components, installations, etc.) and the complex task of detecting their current status in terms of use (intended use and space dimensions, environmental context, etc.) and maintenance (conservation status of building components, age of the technological installations, previous maintenance work, compliance with current regulations, etc.) causes deep difficulties in planning, scheduling and controlling appropriate interventions. Starting from these assumptions, this paper shows the findings of a research, aimed at testing the integrated use of Building Information Modeling (BIM) and 3D Geographic Information Systems (3D GIS) in order to structure knowledge. The research concerns a case study and it has actually led to the development of a BIM-3D GIS workflow which formalizes knowledge and information involved of a significant building, according to its management: the INA houses by Enrico Mandolesi, a residential complex for about 2500 inhabitants built around 1960 in the Eastern suburbs of Cagliari (Italy)

    GIS-HBIM INTEGRATION FOR THE MANAGEMENT OF HISTORICAL BUILDINGS

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    As is well known, Italy's very consistent buildings stock has become the major field for real estate investments and for the related projects and actions. It is a heritage that is often barely known and extremely complex, whose management has until now been addressed in a rather casual and uninformed manner, with unsatisfactory and sometimes disastrous outcomes. The situation is worse in the case of buildings of particular historical, artistic and architectural value so frequent within the heritage of our country. This paper shows the findings of an ongoing research which is aimed at structuring the cognitive process and assessing enhancement and re-functionalisation scenarios of our historical and architectural heritage through the use and integration of information systems such as BIM and the GIS. The work led to the development of a workflow able to integrate the contribution of the HBIM and GIS methodologies in the structuring and management of a wide range of digital data and information useful for its management. The research, focused on “La Gran Torre di Oristano, is aimed at creating the best conditions for an integrated and multidisciplinary strategy of requalification and refunctionalisation of historical and architectural heritage

    Diverting hepatic lipid fluxes with lifestyles revision and pharmacological interventions as a strategy to tackle steatotic liver disease (SLD) and hepatocellular carcinoma (HCC)

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    Abstract Steatotic liver disease (SLD) and Hepatocellular Carcinoma (HCC) are characterised by a substantial rewiring of lipid fluxes caused by systemic metabolic unbalances and/or disrupted intracellular metabolic pathways. SLD is a direct consequence of the interaction between genetic predisposition and a chronic positive energy balance affecting whole-body energy homeostasis and the function of metabolically-competent organs. In this review, we discuss how the impairment of the cross-talk between peripheral organs and the liver stalls glucose and lipid metabolism, leading to unbalances in hepatic lipid fluxes that promote hepatic fat accumulation. We also describe how prolonged metabolic stress builds up toxic lipid species in the liver, and how lipotoxicity and metabolic disturbances drive disease progression by promoting a chronic activation of wound healing, leading to fibrosis and HCC. Last, we provide a critical overview of current state of the art (pre-clinical and clinical evidence) regarding mechanisms of action and therapeutic efficacy of candidate SLD treatment options, and their potential to interfere with SLD/HCC pathophysiology by diverting lipids away from the liver therefore improving metabolic health
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