47 research outputs found
STRESS LAVORO-CORRELATO - IDONEITA’ AL LAVORO: PROPOSTA DI UN METODO OLISTICO NELL’APPROCCIO ALLA VALUTAZIONE DELLA CAPACITA’ LAVORATIVA.
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Liquid chromatography-tandem mass spectrometry method as the golden standard for therapeutic drug monitoring in renal transplant
No full textDe novo homozygous mutation of the C1 inhibitor gene in a patient with hereditary angioedema
No full textMore on: factor V Leiden and prothrombin G20210A polymorphisms as risk factors for miscarriage during a first-intended pregnancy: the matched case-control 'NOHA first' study.
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Role of the M2 haplotype within the annexin A5 gene in the occurrence of pregnancy-related venous thromboembolism.
No full textMarkers of haemostasis and angiogenesis in placentae from gestational vascular complications: impairment of mechanisms involved in maintaining intervillous blood flow
Get PDFIntroduction: Preeclampsia (PE) and fetal growth restriction (FGR) are multifactorial diseases, whose pathogenesis is largely unknown. A significant relationship between haemostasis and angiogenesis in placentae from uneventful pregnancies was previously shown. Materials and Methods: RNA expression of haemostasis (TF, TFPI, TFPI-2, PAI-2, Anx V, TM) and angiogenesis (Ang-1, Ang-2, PlGF, VEGF) markers in placentae from PE (n=12), PE+FGR (n=17) and FGR (n=20) in respect of placentae from uncomplicated pregnancies (n=21) were investigated.
Results: Placentae from complicated pregnancies showed a significant lower expression (p≤0.05 Mann- Whitney U test) of TF, TFPI, TFPI-2, Anx V, PAI-2 than those from in uncomplicated ones. VEGF and PlGF were not different in the considered groups; Ang-1 and Ang-2 were significantly higher (p≤0.05 Mann-Whitney U test) in the PE group.
Correlations between factors involved in haemostasis and those involved in angiogenesis, observed in placentae from uneventful pregnancies are lacking in those from complicated ones. Conclusions: Haemostasis factors are reduced in placentae from complicated pregnancies. The relationship between haemostasis and angiogenesis observed in uncomplicated pregnancies is impaired in PE and FGR
