154 research outputs found
Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas
No full textComparison of natural gas transport variants (liquided or pipeline)
No full textTato práce řeší problematiku nákladů na přepravu zemního plynu v tekutém a plynném stavu. V teoretické části jsem popsal vlastnosti jednotlivých způsobů přepravy. V praktické části jsou pokryty tří navržené trasy, používající již uvedené způsoby přepravy. Vyhodnocení výsledků se provádí pomoci porovnaní hodnot ekonomických ukazatelů NPV a IRR a měrných nákladů. Výstupem práce je roční cash flow každého zvoleného projektu a vyhodnocení zda-li tento projekt je ekonomicky výhodný.This thesis addresses transportation cost of natural gas in fluid and gas state. The theoretical part describes properties of each individual way of transportation. The practical part encompasses three proposed routes, that use aforementioned ways of transportation. Evaluation of the results is based on comparison of net present value, internal rate of return and specific cost. This thesis aims to provide annual cash flow of each chosen project and evaluate whether this project is economically favourable
SILENCING MICAL2 REPRESSES HUMAN CANCER CELL GROWTH AND INVASION INDUCING MESENCHYMAL TO EPITHELIAL TRANSITION
No full textMICAL (Molecules Interacting with CasL)2 belongs to an
evolutionarily conserved family of proteins that catalyze actin
oxidation-reduction reactions destabilizing F-actin in cytoskeletal
dynamics. Here we show for the first time that MICAL2
mRNA is significantly over-expressed in aggressive, poorly differentiated/
undifferentiated, primary gastric and renal human
epithelial cancers. Immunohistochemistry showed MICAL2-
positive cells on the cancer invasive front and in metastasizing
cancer cells inside emboli, but not at sites of metastasis, suggesting MICAL2 expression was “on” in a subpopulation of primary
cancer cells seemingly detaching from the tissue of origin,
enter emboli and travel to distant sites, to be turned “off” once
homing at the metastatic site occurred. In vitro, MICAL2
knock-down was clearly associated with induction of mesenchymal
to epithelial transition, causing reduction of viability and
loss of motility and invasion properties of human cancer cells.
Moreover, expression of MICAL2 cDNA in MICAL2-depleted
cells induced epithelial to mesenchymal transition. All together
our data indicate MICAL2 over-expression is associated with
cancer progression and metastatic disease. MICAL2 might be
an important regulator of epithelial to mesenchymal transition
and therefore a promising target for anti-metastatic therapy
НЕЙРОПСИХОЛОГИЧЕСКАЯ КОРРЕКЦИЯ ПЕРВОКЛАССНИКОВ С ДИАГНОЗОМ НЕЙРОСЕНСОРНАЯ ПОТЕРЯ СЛУХА, ОБУЧАЮЩИХСЯ ПО СИСТЕМЕ ИНКЛЮЗИВНОГО ОБРАЗОВАНИЯ
No full textОдной из наиболее распространенных групп детей с ОВЗ составляют дети с нарушениями слуха. Начало учебы в школе для слабослышащего ребенка требует дополнительных усилий по его адаптации как со стороны самого ребенка, так и со стороны педагогов и родителей. В статье представлены результаты нейропсихологической диагностики высших психических функций детей с диагнозом нейросенсорная потеря слуха (H90), обучающихся в 1-ом классе по системе инклюзивного образования.
Цель. Оценка уровня развития высших психических функций первоклассников с нейросенсорной потерей слуха до и после проведения программы нейропсихологической коррекции.
Материалы и методы исследования. В исследовании приняли участие 16 первоклассников, которым выставлен диагноз нейросенсорная потеря слуха, из них 11 мальчиков (68,8%) и 5 девочек (31,2%) в возрасте 8-9 лет. Нейропсихологическая диагностика детей проводилась с использованием нейропсихологического альбома Ж.М. Глозман и А.Е. Соболевой. Диагностика проводилось до и после проведения программы нейропсихологической коррекции.
Результаты. При первичной диагностике детей выявлено: нарушение слухоречевой памяти; нарушение акустического гнозиса; нарушение квазипространсвенного представления и др. С учётом нейропсихологических особенностей этих детей мы разработали для них коррекционную программу. У первоклассников с нарушением слуха, прошедших нейропсихологическую коррекцию отмечается: улучшение в ориентирование в собственной личности и окружающем мире, улучшение динамического праксиса и праксиса поз, улучшение зрительного восприятия и понимания логико-грамматических конструкций, предложных конструкций, повысилась продуктивность запоминания, стало доступнее обобщение и решение задач.
Выводы. 1. Первоклассники с диагнозом нейросенсорная потеря слуха, имеют отставания в развитии ВПФ. 2. Программа нейропсихологической коррекции направлена не только на развитие нарушенных ВПФ, но и на увеличение адаптационных возможностей детей с нарушением слуха. 3. У детей, прошедших нейропсихологическую коррекцию, выявлено значительное улучшение в пробах и уровне усвояемости школьной программы.
Область применения результатов. Результаты исследования могут быть использованы в работе педагогов и психологов, чья деятельность связана с обучением слабослышащих детей
MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion
No full textThe MICAL (Molecules Interacting with CasL) proteins catalyze actin oxidation-reduction reactions destabilizing F-actin in cytoskeletal dynamics. Here we show for the first time that MICAL2 mRNA is significantly over-expressed in aggressive, poorly differentiated/undifferentiated, primary human epithelial cancers (gastric and renal). Immunohistochemistry showed MICAL2-positive cells on the cancer invasive front and in metastasizing cancer cells inside emboli, but not at sites of metastasis, suggesting MICAL2 expression was 'on' in a subpopulation of primary cancer cells seemingly detaching from the tissue of origin, enter emboli and travel to distant sites, and was turned 'off' upon homing at metastatic sites. In vitro, MICAL2 knock-down resulted in mesenchymal to epithelial transition, reduction of viability, and loss of motility and invasion properties of human cancer cells. Moreover, expression of MICAL2 cDNA in MICAL2-depleted cells induced epithelial to mesenchymal transition. Altogether our data indicate that MICAL2 over-expression is associated with cancer progression and metastatic disease. MICAL2 might be an important regulator of epithelial to mesenchymal transition and therefore a promising target for anti-metastatic therapy
Developing an integrated virtual support system based on navigational information in the framework of ensuring the security of moving vehicles
No full textThe personal archive of O. Kompan in the fonds of the Institute of Manuscript of V. Vernadsky National Library of Ukraine: composition and informational potential
No full textThe article describes the history of acquisition, structure and documental composition of the personal archival fond of the Ukrainian historian Olena Kompan (1816-1986). She was a researcher of the history of Ukraine in the late Middle Ages and the early Modern Era, a scientist with an active social position keeping in touch with the movement of the "sixtiers". The article covers O. Kompan’s biography, outlines her life as a researcher. The author analyzes the structural documental groups of O. Kompan’s personal archive, which were specificated as a result of the fond scientific processing. Particular attention is paid to the section "Scientific and Creative Materials" representing broad scientific interests of O. Kompan as a historian and a historiosopher. A group of documents "Materials of the Fond Creator Relatives", containing the researcher’s husband documents, is of great interest. Her husband was a famous Ukrainian writer - Ivan Senchenko. Another noteworthy category is "Materials of other People" including the documents of the former political prisoners - Ukrainian scientists Pavlo Fedorenko (1880-1962) and Yevhen Stashevsky (1884-1938
Experimental investigation of linear thermal expansion of pyrolytic graphite at high temperatures
No full textTumor suppressor function of the SEMA3B gene in human lung and renal cancers
No full textThe SEMA3B gene is located in the 3p21.3 LUCA region, which is frequently affected in different types of cancer. The objective of our study was to expand our knowledge of the SEMA3B gene as a tumor suppressor and the mechanisms of its inactivation. In this study, several experimental approaches were used: tumor growth analyses and apoptosis assays in vitro and in SCID mice, expression and methylation assays and other. With the use of the small cell lung cancer cell line U2020 we confirmed the function of SEMA3B as a tumor suppressor, and showed that the suppression can be realized through the induction of apoptosis and, possibly, associated with the inhibition of angiogenesis. In addition, for the first time, high methylation frequencies have been observed in both intronic (32-39%) and promoter (44-52%) CpG-islands in 38 non-small cell lung carcinomas, including 16 squamous cell carcinomas (SCC) and 22 adenocarcinomas (ADC), and in 83 clear cell renal cell carcinomas (ccRCC). Correlations between the methylation frequencies of the promoter and the intronic CpG-islands of SEMA3B with tumor stage and grade have been revealed for SCC, ADC and ccRCC. The association between the decrease of the SEMA3B mRNA level and hypermethylation of the promoter and the intronic CpG-islands has been estimated in renal primary tumors (P < 0.01). Using qPCR, we observed on the average 10- and 14-fold decrease of the SEMA3B mRNA level in SCC and ADC, respectively, and a 4-fold decrease in ccRCC. The frequency of this effect was high in both lung (92-95%) and renal (84%) tumor samples. Moreover, we showed a clear difference (P < 0.05) of the SEMA3B relative mRNA levels in ADC with and without lymph node metastases. We conclude that aberrant expression and methylation of SEMA3B could be suggested as markers of lung and renal cancer progression
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