164 research outputs found
An allosteric redox switch in domain V of β2-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition
No full textβ2-glycoprotein I (β2GPI) is an abundant multi-domain plasma protein that plays various roles in the clotting and complement cascades. It is also the main target of antiphospholipid antibodies (aPL) in the acquired coagulopathy known as Antiphospholipid Syndrome (APS). Previous studies have shown that β2GPI adopts two interconvertible biochemical conformations, oxidized and reduced, depending on the integrity of the disulfide bonds. However, the precise contribution of the disulfide bonds to β2GPI structure and function is unknown. Here, we substituted cysteine residues with serine to investigate how the disulfide bonds C32-C60 in domain I (DI) and C288-C326 in domain V (DV) regulate β2GPI's structure and function. Results of our biophysical and biochemical studies support the hypothesis that the C32-C60 disulfide bond plays a structural role, whereas the disulfide bond C288-C326 is allosteric. We demonstrate that absence of the C288-C326 bond, unlike absence of the C32-C60 bond, diminishes membrane binding without affecting the thermodynamic stability and overall structure of the protein, which remains elongated in solution. We also document that, while absence of the C32-C60 bond directly impairs recognition of β2GPI by pathogenic anti-DI antibodies, absence of the C288-C326 disulfide bond is sufficient to abolish complex formation in the presence of anionic phospholipids. We conclude that the disulfide bond C288-C326 operates as a molecular switch capable of regulating β2GPI's physiological functions in a redox-dependent manner. We propose that in APS patients with anti-DI antibodies, selective rupture of the C288-C326 disulfide bond may be a valid strategy to lower the pathogenic potential of aPL
Author and Owner Intersection in Sound Recordings in The Copyright Act of India
No full text245-250The present work focuses on the intersection of author and owner concerning sound recordings. The interpretation of copyright law on the author and owner intersection by the Court's are rather varied. It may be because the restricted issues at its hand lead the courts. More particularly, interpretation of provisos (b) and (c) of Section 17 of The Copyright Act, 1957 leads to differing interpretations by the Courts. The present analysis is made by studying three recent judgments to understand the author and owner conflicts of sound recordings
Full C-Band Tunable V-Cavity-Laser based TOSA and SFP Transceiver Modules
No full textWe report the latest development in tunable transmitter optical sub-assembly (TOSA) and small form-factor pluggable (SFP) transceivers based on simple and compact V-cavity laser (VCL), aiming for low-cost deployment in metro, access and data center networks. The VCL employs a half-wave coupler to achieve high side-mode suppression ratio (SMSR) and the Vernier effect to achieve a wide wavelength tuning range. Full C-band tuning from 1529.55-nm to 1566.31-nm with SMSR above 36 dB is demonstrated. Since the laser does not involve any grating or epitaxial regrowth, and has a simple tuning algorithm, it allows simpler processes for fabrication and testing as compared to other widely tunable laser structures. Compact TOSAs and SFP transceiver modules have been developed for full C-band tuning with up to 93 channels at 50 GHz spacing. Transmission experiments are carried out for direct modulation with data rates from 2.5 Gbps to 8.5 Gbps. The results of reliability tests of the modules are also presented
Efficient Data Assumption and Optimization of Analog Response Communication Systems
No full textThis paper is focused on the examination of connection between the premier remote reason exactitude of transmission information and qualities for driving edge correspondence structures and straightforward data cesium (AFCS) identified with transmission of signs from fundamental sources. It's displayed that the mean sq. oversight of transmission picks information properties of AFCS. Varieties between the cutoff purposes of AFCS thought of as summed up correspondence channel and their forward channel square measure investigated. The new impacts appearing in incredible AFCS and in DCS working near Shannon's cutoff square measure thought of also. Amid this works advanced and essential correspondence frameworks were thought of with none inclinations and no confirmation that the use of simple cesium is frequently less able than modernized correspondence structures had been given start inside the no in this way far off past. The secured comes about unambiguously showed the capacity of simple data cesium to transmit the signs while not committal to composing with to a little degree rate up to the uttermost ranges of the forward control
Clinico-etiological profile of acute kidney injury in children admitted to paediatric intensive care unit of a tertiary care centre
No full textBackground: Acute Kidney Injury (AKI) refers to a reversible accumulation of urea, creatinine and nitrogenous waste products and disturbances in maintenance of fluid and electrolyte homeostasis. The incidence of AKI continues to increase in the Paediatric age group particularly in critically ill children with the etiology shifting from primary renal disorders to multifactorial cause. The objective of the study to determine the incidence, clinical profile and outcome of AKI in critically ill children using p-RIFLE criteria.Methods: A prospective observational study was done with 342 children aged between 1-12 years, admitted in Paediatric Intensive Care Unit (PICU) of Institute of Child Health and Research Centre, Madurai Medical College, Madurai during July 2015 to June 2016.Results: The overall incidence of AKI among critically ill children was 30.1%. The mortality rate was 43.7% and 20.7% patients with AKI had partial renal recovery at the time of discharge. 27.2% patients required renal replacement therapy (RRT). Infectious causes 57.3% (Sepsis, Meningoencephalitis, Bronchopneumonia) dominated the etiological profile.Conclusions: Incidence of AKI is high in critically-ill children. AKI continues to be associated with adverse outcomes, including high mortality and partial renal recovery.</jats:p
Texture Classification Based on Empirical Wavelet Transform Using LBP Features
No full textAutomatic inspection systems become more importance for industries with high productive plans especially in texture industry. A novel approach to Local Binary Pattern (LBP) feature for texture classification is proposed in this system. At the first, the proposed Empirical Wavelet Transform (EWT) based texture classification is tested on gray scale and color images by using Brodatz texture images. The gray scale and color image is decomposed by EWT at 2 and 3 level of decomposition. LBP features are calculated for each empirical transformed image. Extracted features are given as input to the classification stage. K-NN classifier is used for classification stage. The result of the proposed system gives satisfactory classification accuracy of over 98% for all types of images
WareWise: Business Development Management Framework based on Device-to-Device Industrial Internet of Things
No full textInternet of Things (IoT) - empowered data framework arrangements are developing in different spaces, for example, remote social insurance, keen coordination’s, farming et cetera. In the mean time, Business Development Management Frameworks (BDMF) has turned out to be promising instruments for driving and overseeing gadgets inside IoT frameworks. Be that as it may, past works have not completely tended to how the IoT-based BDMF can proceed with their execution when the included IoT gadgets don't have a dependable Internet association. In this paper, we propose a framework outline for decentralized device to device (D2D) - based BD execution, where versatile hubs have the ability of both executing BDs additionally moving BD execution to different hubs amid runtime. We apply this plan to the field of shrewd coordination’s, keeping in mind the end goal to empower savvy products checking. The exhibited merchandise observing arrangement empowers responding to occasions when they happen, while likewise producing a hint of the checking execution history. A model concentrating on the movement usefulness of the stage has been actualized and tried to assess its execution with regards to the specified savvy coordination’s situation
Texture Classification Based on Empirical Wavelet Transform Using LBP Features
No full textAutomatic inspection systems become more importance for industries with high productive plans especially in texture industry. A novel approach to Local Binary Pattern (LBP) feature for texture classification is proposed in this system. At the first, the proposed Empirical Wavelet Transform (EWT) based texture classification is tested on gray scale and color images by using Brodatz texture images. The gray scale and color image is decomposed by EWT at 2 and 3 level of decomposition. LBP features are calculated for each empirical transformed image. Extracted features are given as input to the classification stage. K-NN classifier is used for classification stage. The result of the proposed system gives satisfactory classification accuracy of over 98% for all types of images
NFC Secured Offline Password Storage
No full textIn this paper is all about constructing a device called “One-WORD” that aims to solve this problem. One-word is an offline password keeper aimed at saving and encrypting the passwords in a more secure manner. The main device contains the encrypted passwords while a secure NFC smartcard and a personal pin-code allows the decryption. Even if an attacker is able to get hold the smartcard, or the device it is completely useless without the personal code.
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