1,720,995 research outputs found
Bisphosphonates and osteomyelitis of the jaw: a pathogenic puzzle.
No full textThe maxillary and mandibular bones undergo high-turnover remodeling to maintain mechanical competence. Common dental or periodontal diseases can increase local bone turnover. Bisphosphonates (BPs) accumulate almost exclusively in skeletal sites that have active bone remodeling. The maxillary and mandibular bones are preferential sites for accumulation of BPs, which become buried under new layers of bone and remain biologically inactive for a long time. Surgical odontostomatological procedures create open bony wounds that heal quickly and without infection, as a result of activation of osteoclasts and subsequently osteoblasts. Once BPs are removed from the bone via activation of osteoclasts after a tooth extraction or a periodontal procedure, they induce osteoclast apoptosis. This inhibition of osteoclast bone resorption impairs bone wound healing because of decreased production of cytokines derived from the bone matrix, and the bone is exposed to the risk of osteomyelitis and necrosis. The pathogenic relationship between BPs and osteonecrosis of the jaw is unclear, but there is evidence to indicate an association between high-dose BP treatment and exposure to dental infections or oral surgical procedures. A better knowledge of the interactions between BPs and jaw and maxillary bone biology will improve clinical and therapeutic approaches
Diagnostic value of urinary cyclic AMP measurement in patients with calcium nephrolithiasis
No full textOne hundred patients with recurrent calcium nephrolithiasis were submitted to the Pak test. At fasting state hypercalciuria was found in 27 cases, while a group of 16 further patients became hypercalciuric after oral calcium load. Only measurement of urinary cAMP excretion in both conditions made it possible to diagnose renal hypercalciuria in 9 out of 27 patients in the former group; according to test results 4 patients were expected to have primary hyperparathyroidism, but afterwards the disease was identified in only one case
[Comparative studies of the behavior of blood calcium and urinary hydroxyproline after infusion of calcitonin and glucagon in patients with Paget's disease]
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Trattamento con diclorometilendifosfonato delle metastasi ossee da carcinoma prostatico
No full textTrattamento con diclorometilendifosfonato delle metastasi ossee da carcinoma prostatic
Scritti e ricerche di grammatica italiana, saggi di G. C. Lepschy, N. Ruwet, C. Schwarze, M. G. de Boer, D. Cernecca, G. Cinque, G. P. Clivio, M. Cirstea, M. E. Conte, N. Costabile, A. Giurescu, H. Krenn, V. Lo Cascio, Ž. Muljačić, L. Renzi; pubblicazione del Centro per lo studio dell'insegnamento all'estero dell'italiano dell'Università degli Studi di Trieste, Edizioni Lint, Trieste, 1972, 334 pp.
Full text linkScritti e ricerche di grammatica italiana, saggi di G. C. Lepschy, N. Ruwet, C. Schwarze, M. G. de Boer, D. Cernecca, G. Cinque, G. P. Clivio, M. Cirstea, M. E. Conte, N. Costabile, A. Giurescu, H. Krenn, V. Lo Cascio, Ž. Muljačić, L. Renzi; pubblicazione del Centro per lo studio dell'insegnamento all'estero dell'italiano dell'Università degli Studi di Trieste, Edizioni Lint, Trieste, 1972, 334 pp
Acute effects of deflazacort and prednisone on rates of mineralization and bone formation
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