3,603 research outputs found
Utilizing biomarkers in colorectal cancer: an interview with Ajay Goel
No full text Ajay Goel speaks to Rachel Jenkins, Commissioning Editor. Ajay Goel, PhD, is a Professor and Director, Center for Gastrointestinal Research, and Director, Center for Translational Genomics and Oncology, at the Baylor Scott & White Research Institute, Baylor University Medical Center in Dallas, Texas. Dr Goel has spent more than 20 years researching cancer and has been the lead author or contributor to over 240 scientific articles published in peer-reviewed international journals and several book chapters. He is also a primary inventor on more than 15 international patents aimed at developing various biomarkers for the diagnosis, prognosis and prediction of gastrointestinal cancers. He is currently using advanced genomic and transcriptomic approaches to develop novel DNA- and miRNA-based biomarkers for the early detection of colorectal cancers. In addition, he is researching the prevention of gastrointestinal cancers using integrative and alternative approaches, including botanical products such as curcumin (from turmeric) and boswellia. Dr Goel is a member of the American Association for Cancer Research (AACR) and the American Gastroenterology Association (AGA) and is on the international editorial boards of several journals including Gastroenterology, Clinical Cancer Research, Carcinogenesis, PLoS ONE, Scientific Reports, Epigenomics, Future Medicine, Alternative Therapies in Heath and Medicine and World Journal of Gastroenterology. He is also actively involved in peer-reviewing activities for more than 100 international scientific journals and various grant review panels of various national and international funding organizations. His research has been actively funded by various private and federal organizations, including funding from the National Cancer Institute (NCI) at the NIH, American Cancer Society (ACS) and other state organizations. He has won more than dozen awards and honors, including the Union of European Gastroenterology Federation's Distinguished Researcher Award, multiple Poster of Distinction Awards from the AGA, and Visiting Professorships from various national and international academic institutions and academic bodies. Some of his key research interests include: Understanding the basic genetics and epigenetic basis of gastrointestinal cancers; Use of epigenetic markers, both DNA and RNA, for the early detection of colorectal, pancreatic and other gastrointestinal cancers; Personalized medicine and treatment of gastrointestinal cancers; Chemoprevention, using complementary and alternative approaches using nutraceuticals such as curcumin, green tea, resveratrol and other botanicals. </jats:p
Alternative technique of cervical spinal stabilization employing lateral mass plate and screw and intra-articular spacer fixation
No full textAim: The author discusses an alternative technique of segmental cervical spinal fixation. Material and Methods: The subtleties of the technique are discussed on the basis of experience with 3 cases with a follow-up of between 30 and 36 months. Technique: The technique involves debridement of facetal articular cartilage, distraction of facets, jamming of ′Goel spacer′ into the articular cavity and fortification of the fixation by lateral mass plate and screw fixation. The ′double-insurance′ method of fixation is safe for vertebral artery, nerve roots and spinal neural structures and the fixation is strong. Conclusions: The discussed technique is safe and provides a strong fixation and a ground for ultimate arthrodesis
Author Reply Re: Goel A. Research training during residency. Indian J Urol 2017;33:257-8
No full textAlkali-free bioactive glass composition, U.S. Patent 9,238,044
No full textThe present invention relates to development of bioactive glass/glass-ceramic composition that are able to promote a fast deposition layer of carbonated hydroxyapatite upon immersion in simulated body fluid (SBF) for time periods as short as one hour. Such composition might include fluorides, and a variety of oxides (or their precursor compounds), such as Na2O—Ag2O—SrO—CaO—MgO—ZnO—P2O5—SiO2—Bi2O3—B2O3—CaF2, be prepared by the melt route or by the sol-gel process, with the specific composition and the preparation route selected according to the intended functionalities, which can present controlled biodegradation rate and bactericidal activity. The powders derived from glass melts purred in cold water (frits) may completely densify by sintering at temperatures up to 800° C. without devitrification, resulting in bioglass compacts with high flexural strength (˜85 MPa). The bioactive glass powders prepared by sol-gel densify at lower temperatures due to their higher specific surface area and reactivity
Community-based organisations: role in settling immigrants
No full textIt has been well acknowledged in the literature that successful settlement of new arrivals (both international and interstate) and their families is crucial for theirintegration and well-being in a host society. This will also result in population sustainability and meetingindustry requirements in regional areas. This chapter posits that community-based organisations (CBOs) are in a unique position to provide settlement services which are socially inclusive and evolve community participation under immigration department policy guidelines. Thechapter illustrates how a community development approach is a useful theory/constructto guide the practice of a community-based organisation that isproviding settlement services to new immigrants. This is demonstrated by using a case study of the 'Settling our Future' program provided through one of the community-basedorganisations in aregional city of South Australia.The author demonstrates that community development principles and approaches are the backbone of providing effective servicesto meet the needs of new arrivals in the regional town. The chapterfurther examines the role of the community development worker as a facilitator in establishing, developing and sustaining these initiatives which have a community basis
Community development and mental health promotion
No full textIt is estimated that 450 million people are experiencing mental illness at any one time, most of whom live in developing countries and a great majority of them being women (World Health Organization, 2001). Mental illness affects one in four people at some stage during their lives. This paper based on a review of literature delineates the scope of community development in mental health promotion. To make more meaning relevant Australian references are utilised in this review essay. Mental illness is common in Australia with one in five Australians experiencing a mental illness at some stage in their lives, and many experiencing more than one mental illness at one time (Mindframe National Media Initiative, 2011). In this paper the authors review perspectives currently available for health promotion in social work in relation to mental health. The authors emphasise the importance of strength-based community development perspectives in mental health practice and an attempt is made to put forward an integrated model for, addressing mental health issues in a community context. The model looks at highlighting the need for developing and sustaining community spirit and promoting resilience in communities
Sketches of thought
No full textMuch of the cognitive lies beyond articulate, discursive thought, beyond the reach of current computational notions. In Sketches of Thought, Vinod Goel argues that the cognitive computational conception of the world requires our thought processes to be precise, rigid, discrete, and unambiguous, yet there are dense, ambiguous, and amorphous symbol systems, like sketching, painting, and poetry, found in the arts and much of everyday discourse that have an important, nontrivial place in cognition. Goel maintains that while on occasion our thoughts do conform to the current computational theory of mind, they often are -- indeed must be - vague, fluid, ambiguous, and amorphous. He argues that if cognitive science takes the classical computational story seriously, it must deny or ignore these processes, or at least relegate them to the realm of the nonmental. As a cognitive scientist with a design background, Goel is in a unique position to challenge cognitive science on its own territory. He introduces design problem solving as a domain of cognition that illustrates these inarticulate, nondiscursive thought processes at work through the symbol system of sketching. He argues not that such thoughts must remain noncomputational but that our current notions of computation and representation are not rich enough to capture them. Along the way, Goel makes a number of significant and controversial interim points. He shows that there is a principled distinction between design and nondesign problems, that there are standard stages in the solution of design problems, that these stages correlate with the use of different types of external symbol systems, that these symbol systems are usefully individuated in Nelson Goodman's syntactic and semantic terms, and that different cognitive processes are facilitated by different types of symbol systems
Understanding community and community development
No full textThis chapter delineates what is meant by the term 'community' in community development practice. Is the meaning changing in the context of development taking place in the socio-political and technological areas or is it some aspects of community functioning that are important in community development practice? Thus, the nature of community and its function towards meeting goals of human society has been explored. Social workers work with communities at different levels ranging from micro to mezzo and macro level. Their processes in community development are guided by values and principles based on human rights, social and ecological justice. These are at the core of community development practice. While applying these values and principles and working at the grassroots level, social workers face dominant societal views and power structures that operate at local, regional, national and even international levels. Thus it is imperative to revisit the knowledge and skills a social worker needs to have in the field of community development
Models as Tools to Aid Thinking
No full textRitter H. Models as Tools to Aid Thinking. In: Glatzeder B, Goel V, von Müller A, eds. Towards A Theory Of Thinking: Building Blocks for A Conceptual Framework. Berlin, Heidelberg: Springer; 2010: 347-374
Syllable - A Promising Recognition Unit for LVCSR
No full textGanapathiraju A, Goel V, Picone J, et al. Syllable - A Promising Recognition Unit for LVCSR. In: Proceedings of the IEEE Automatic Speech Recognition and Understanding Workshop. Santa Barbara, California, USA; 1997: 207-214
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