1,721,102 research outputs found

    Operational scheme for general methods of extraction and identification of narcotics in nonbiological material

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    A review with 71 refs., of techniques used by the authors and others in forensic analyses of narcotic samples, with respect both to the detection and identification of specifically sought-for materials and to the general anal. of unknown samples. Specific analyses are described for Cannabis indica, amphetamines, cocaine, opium, and heroin. The applications of gas chromatog.-mass spectrometry, NMR and ir spectroscopy, and various chromatog. techniques to such assays are described

    Drug monitoring in the therapeutic environment

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    A review, with 13 refs., considering 2 related topics: pharmacokinetic concepts for predicting blood levels of a drug following a given dose, and anal. methods for the detn. and monitoring of the concns. actually attained

    Cocaine, benzoylecgonine, and ecgonine methyl ester determinations in postmortem urine and blood gas chromatography and capillary gas chromatography after Extrelut extraction

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    A simple and rapid method for cocaine, benzoylecgonine, and Me ecgonine detn. in postmortem human urine and blood by gas chromatog. and capillary gas chromatog. was described. Elution through Extrelut columns is sufficient to complete the procedure. Protein denaturation with acetonitrile is very important for recovery of cocaine and its metabolites in postmortem blood and allows use of the Extrelut. The procedure could be improved, esp. regarding the instrumental step. Reliable detns. of cocaine, benzoylecgonine, and Me ecgonine could probably be obtained via capillary gas chromatog. with a NP detector using the same capillary column
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