1,720,997 research outputs found
2-TRIFLUOROMETHANESULFONYLOXY-INDOLE-1-CARBOXYLIC ACID ETHYL ESTER: A USEFUL REAGENT FOR 2-SUBSTITUTED INDOLES
No full textDomino addition/annulation of delta-alkynylaldehydes and oxygen nucleophiles: a new entry to [1,4]oxazino[4,3-a]indoles
No full textThe unusual [1,4]oxazino[4,3-a]indole nucleus was prepared, under mild reaction conditions, by reacting 1-alkynyl-1H-indole-2-carbaldehydes with various alkoxides, generated in situ from the corresponding alkyl, benzyl, allyl and propargyl alcohols
TiCl4/t-BuNH2-promoted hydroamination/annulation of delta-keto-acetylenes : synthesis of novel pyrrolo[1,2-a]indol-2-carbaldehydes
No full textAn original TiCl4/t-Bu-NH2 mediated hydroamination/annulation domino reaction of delta-keto-acetylenes is described. The synthesis of pyrrolo[1,2-a]indole-2-carbaldehydes, starting from 2-carbonyl-1-propargyl-1H-indoles run under mild reaction conditions. A conceivable mechanism is also discussed. TiCl4 has proved to be an effective multi-activity reagent: catalyst / Lewis acid / water scavenger. Some unpublished 2-carbonyl-1-propargyl-1H-indoles are prepared by means of Suzuki- and Negishi-type reactions
2-Trifluoromethanesulfonyloxyindole-l-carboxylic acid ethyl ester : a practical intermediate for the synthesis of 2-carbosubstituted indoles
No full textReady accessible 2-trifluoromethanesulfonyloxyindole-1-carboxylic acid ethyl ester undergoes palladium-catalyzed coupling reactions with different partners giving rise to 2-aryl, heteroaryl, vinyl, allyl, and alkynyl indoles in good to excellent yield
Large-Grained (111)-Oriented Cdte Thin-Films Grown By Quasi-Rheotaxy On Steel Substrates
No full textReazioni domino di addizione/annulazione di chetoacetileni
No full textLe strutture policicliche contenenti un sistema indolico condensato sono il nucleo base di numerose molecole farmacologicamente attive, aventi un’ampia possibilità d’impiego terapeutico (antitumorali, antivirali, antibiotici, PKC inibitori, antifungini). Di recente, con l’intento di ottenere tali sistemi, abbiamo rivolto la nostra attenzione verso le reazioni domino di addizione/annulazione di chetoacetileni.1 Tali reazioni prevedono una ciclizzazione intramolecolare promossa da nucleofili all’ossigeno2 o all’azoto3,4,5 su tripli legami non attivati.
In questo nuovo lavoro abbiamo valutato la percorribilità di nuove vie sintetiche per l’ottenimento di indoli ciclizzati in posizione 1,2 o 2,3 attraverso attacco di nucleofili al carbonio. All’iniziale formazione dell’enammina, terminale nucleofilo del sistema, fa seguito la reazione di carbociclizzazione che porta alla formazione del nucleo policlico
Palladium catalyzed synthesis of 4-substituted-2-phenylimidazoles from N-propargyl-benzamidine
No full textPreliminary results of an original approach to 4-substituted-2-phenylimidazoles starting from readily available N-propargyl-benzamidine and aryl halides are reported. Best yields were obtained using aryl halides bearing an electron-withdrawing group. Plausible mechanisms are also discussed
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