464 research outputs found
Changed in translation: mRNA recoding by −1 programmed ribosomal frameshifting.
No full textProgrammed −1 ribosomal frameshifting (−1PRF) is an mRNA recoding event commonly utilized by viruses and bacteria to increase the information content of their genomes. Recent results have implicated −1PRF in quality control of mRNA and DNA stability in eukaryotes. Biophysical experiments demonstrated that the ribosome changes the reading frame while attempting to move over a slippery sequence of the mRNA – when a roadblock formed by a folded downstream segment in the mRNA stalls the ribosome in a metastable conformational state. The efficiency of −1PRF is modulated not only by cis-regulatory elements in the mRNA but also by trans-acting factors such as proteins, miRNAs, and antibiotics. These recent results suggest a molecular mechanism and new important cellular roles for −1PRF
AUTHOR CORRECTION - ERS International Congress 2019:highlights from Best Abstract awardees
No full textLorna E. Latimer, Marieke Duiverman, Mahmoud I. Abdel-Aziz, Gulser Caliskan, Sara M. Mensink-Bout, Alberto Mendoza-Valderrey, Aurelien Justet, Junichi Omura, Karthi Srikanthan, Jana De Brandt. Breathe 2019; 15: e143–e149. This article from the December 2019 issue of Breathe was published with an error in the name of one of the authors. The corrected author list is shown above. The article has been corrected and republished online.</p
Astronomy Letters, V. 26, I. 11
No full textAstronomy Letters -- November 2000
Volume 26, Issue 11, pp. 691-755
Spectral Variability of the X-ray Pulsar Hercules X-1
A. A. Lutovinov, S. A. Grebenev, M. N. Pavlinsky, and R. A. Sunyaev
pp. 691-698 Full Text: PDF (126 kB)
Energy Release During Disk Accretion onto a Rapidly Rotating Neutron Star
N. R. Sibgatullin and R. A. Sunyaev
pp. 699-724 Full Text: PDF (315 kB)
A Preliminary Version of a Catalog of High- Low-Mass X-ray Binaries
O. H. Guseinov, A. T. Sayagac, A. Allakhverdiev, H. Caliskan, S. Ozdemir, S. K. Yerli, and A. Ankay
pp. 725-729 Full Text: PDF (56 kB)
Oscillation Structure of Gamma-Ray Bursts and Their Possible Origin
S. S. Gershtein
pp. 730-735 Full Text: PDF (79 kB)
Peculiarities of the Plasma Mechanism of Radio Emission from Late-Type Stars
V. V. Zaitsev, E. G. Kupriyanova, and A. V. Stepanov
pp. 736-742 Full Text: PDF (101 kB)
An Axisymmetric Magnetohydrodynamic Model for the Interaction of the Solar Wind with the Local Interstellar Medium
D. B. Aleksashov, V. B. Baranov, E. V. Barsky, and A. V. Myasnikov
pp. 743-749 Full Text: PDF (88 kB)
A Simple Analytic Model of Reconnection in a High-Temperature Turbulent Sheet
A. V. Oreshina and B. V. Somov
pp. 750-755 Full Text: PDF (80 kB)Archived web conten
Programmed –1 Frameshifting by Kinetic Partitioning during Impeded Translocation
No full textSummaryProgrammed –1 ribosomal frameshifting (−1PRF) is an mRNA recoding event utilized by cells to enhance the information content of the genome and to regulate gene expression. The mechanism of –1PRF and its timing during translation elongation are unclear. Here, we identified the steps that govern –1PRF by following the stepwise movement of the ribosome through the frameshifting site of a model mRNA derived from the IBV 1a/1b gene in a reconstituted in vitro translation system from Escherichia coli. Frameshifting occurs at a late stage of translocation when the two tRNAs are bound to adjacent slippery sequence codons of the mRNA. The downstream pseudoknot in the mRNA impairs the closing movement of the 30S subunit head, the dissociation of EF-G, and the release of tRNA from the ribosome. The slippage of the ribosome into the –1 frame accelerates the completion of translocation, thereby further favoring translation in the new reading frame
Clinical performance of a new bidirectional rotational mechanical lead extraction sheath
No full textAims We investigated the safety and efficacy of a new bidirectional rotational mechanical extraction sheath (Evolution RL, Cook Medical, USA). Methods and results From April 2013 until September 2014, we performed lead extraction procedures in 71 patients with 112 leads scheduled for extraction. During this time period, we used the new Evolution RL rotational sheath in 40 patients on 52 leads (24 pacemaker leads and 28 implantable cardioverter-defibrillator leads) scheduled for extraction. The mean lead implant duration in these patients was 100.2 (22-271) months. Forty leads were right ventricular leads, 10 right atrial leads, and 2 coronary sinus leads. Clinical success among the leads approached with the Evolution RL device was 98.1%. Operative mortality was zero. Major complications did not occur. Four minor complications were encountered (all pocket haematomas). No device-related complications were noted. In cases with multiple leads in situ, no wrapping of companion leads was seen. The average number of extraction tools used per lead was 2.4 (2-4) in the Evolution RL cohort. Conclusion Based on the presented results of our initial experience with the new bidirectional rotational mechanical extraction device, its use is safe and efficient with high success rates in long implanted lead
Epicardial left ventricular leads via minimally invasive technique: a role of steroid eluting leads
No full textAutomotive Power Generation and Control
No full textThis paper describes some new developments in the application of power electronics to automotive power generation and control. A new load-matching technique is introduced that uses a simple switched-mode rectifier to achieve dramatic increases in peak and average power output from a conventional Lundell alternator, along with substantial improvements in efficiency. Experimental results demonstrate these capability improvements. Additional performance and functionality improvements of particular value for high-voltage (e.g., 42 V) alternators are also demonstrated. Tight load-dump transient suppression can be achieved using this new architecture. It is also shown that the alternator system can be used to implement jump charging (the charging of the high-voltage system battery from a low-voltage source). Dual-output extensions of the technique (e.g., 42/14 V) are also introduced. The new technology preserves the simplicity and low cost of conventional alternator designs, and can be implemented within the existing manufacturing infrastructure.MIT/Industry Consortium on Automotive Electrical/Electronic Components and System
Correction to
No full textThe article “Intermittent levosimendan infusion in ambulatory patients with end‑stage heart failure: a systematic review and meta‑analysis of 984 patients”, written by Hagar Elsherbini, Osama Soliman, Casper Zijderhand, Mattie Lenzen, Sanne E. Hoeks, Rasha Kaddoura, Mohamed Izham5, Abdulaziz Alkhulaifi, Amr S. Omar, and Kadir Caliskan, was originally published electronically on the publisher’s internet portal on 11 April 2021 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 10 June 2021 to</p
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