25 research outputs found

    Evaluation of Msh2,Mih1,Brca1,and Fhit protein expression in T1N0M0 breast cancer

    No full text
    • expression in T1 NO M0 breast cancer Evaluation of Msh2, Mlhl, Brcal and Fhit protein E. Giarnieri 1, G. De Francesco 2, C. Amanti 3, B. Bucci 4, V. Catracchia 5, V. Moscaroli 6, M. Lo Russo 7, M. Giovagno@. i University of Rome "La Sapienza"IISchoolofMedicine, PathologySAndreaHospital, Rome,Italy; 2UniversityofRome"LaSapienza"IISchoolofMedicine, PathologyS Andrea Hospital, Rome, Italy; 3University of Rome "La Sapienza" II School of Medicine, Surgery S Andrea Hospital, Rome, Italy; 4Fatebenefratelli S Pietro Hospital, Research Center, Rome, Italy; 5University of Rome "La Sapienza"IISchoolofMedicine, SurgerySAndreaHospital, Rome,Italy; 6UniversityofRome"LaSapienza"IISchoolofMedicine, SurgerySAndrea Hospital, Rome, Italy; 7University of Rome "La Sapienza" II School of Medicine, SurgerySAndreaHospital, Rome,Italy;8UniversityofRome"La Sapienza"IISchoolofMedicine, PathologySAndreaHospital, Rome,Italy The development of breast cancer, as observed in other malignancies, is a multistep process in which genetic changes are required to convert normal epithelium to invasive cancer. To analyze relevant factors and their effects on neoplastic progression in T1 NO M0 breast cancer, a panel of genetic mark- ers was studied. Expression of Msh2, Mlhl, Brcal and Fhit protein were eval- S15 S 16 Poster Session I. Biology Thursday, 27 January 2005 uated by immunohistochemistry in 41 patients with T1NOM0 invasive ductal breast carcinoma. Statistically significant correlations between Msh2, Mlhl and Brcal protein expression were detected (p 1 cm to _ 1 cm to _<2 cm diameter proved negative immunoreactivity for Mlhl with a statistical realationship (p < 0.035). A relationship betwee

    Approccio periareolare totale nella chirurgia conservativa della mammella

    No full text
    [Total periareolar approach in breast-conserving surgery]. [Article in Italian] Amanti C, Regolo L, Moscaroli A, Lo Russo M, Catracchia V. Source Università La Sapienza, II Facoltà di Medicina e Chirurgia, Policlinico Sant'Andrea, Roma. Abstract Plastic and oncological breast surgery have to be considered as two aspects of the same treatment. The term "oncoplastic surgery" refers to the use of plastic surgery techniques in breast cancer surgery, in order to avoid and to correct the adverse aesthetic findings. The care of cosmetic sequelae of breast cancer surgery has reached an important therapeutic role for psychological consequences of disease and because of the higher patients expectations of a good aesthetic result. Considering the concept of oncoplastic surgery, since 1999 the authors began to use a periareolar approach in the breast conserving therapy (BCT), associated to axillary dissection performed through the same periareolar incision. This technique is not different from the traditional quadrantectomy in the extension of the glandular resection, while the skin may be preserved in according to the conventional protocols of BCT. Oncological and aesthetic results have proved to be safe and satisfactory. PMID: 12903581 [PubMed - indexed for MEDLINE
    corecore