816 research outputs found
An interview with Michael Barresi
No full textMichael Barresi is Professor of Biological Sciences at Smith College, Northampton, MA, USA, where he uses the zebrafish to understand central nervous system development. Michael is also Program Director of the ‘Student Scientists’ outreach project and has made significant contributions to teaching developmental biology, including being co-author and illustrator of the textbook Developmental Biology, producing developmental documentaries and starting the Online Developmental Teaching Forums. He was awarded the 2021 Viktor Hamburger Outstanding Educator Prize from the Society of Developmental Biology (SDB). We caught up with Michael over Teams to hear more about his career and love of learning
Meningiomas: Role of Semaphorin3A Protein in Antiangiogenesis
No full textMeningiomas represent frequent tumors mainly characterized by a benign histology and an indolent clinical course. The histological grade and extent of surgical resection are considered to be the most powerful prognosticators for these neoplasias. Nonetheless, a percentage of meningiomas do display relapses despite a total macroscopic resection, although the reasons of this phenomenon still remain to be fully clarified. Herein the prognostic value of angiogenesis and of the expression of its regulators in completely surgically resected meningiomas is discussed. In particular, the role of semaphorin3A (SEMA3A) in the regulation of angiogenesis and the correlation between its expression and the risk of recurrence of meningiomas are illustrate
Neutrophil gelatinase-associated lipocalin immunoexpression in colorectal carcinoma: A stage-specific prognostic factor?
No full textTNM post-surgical staging is considered to be one of the most powerful prognosticators for colorectal carcinoma. Although patient survival mostly decreases concomitantly to stage increase, in a percentage of cases TNM stage appears only to express the anatomic extent of the neoplasia with no correlation with clinical outcome. Thais, the identification of additional prognostic markers for colorectal cancer is required. Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein that appears to play an important role in colorectal cancer progression. In order to evaluate whether NGAL expression may be considered as a predictor of colorectal cancer progression, we analyzed its correlation with clinicopathological characteristics, as well as with patient progression-free survival in a series of surgically resected colorectal carcinomas. A variable NGAL immunoexpression was found in 24 out of the 64 analyzed cases. When only the positive cases were considered, a significant association was found between a high NGAL expression and the presence of distant metastases or high tumor stage. In addition, the presence of NGAL was a significant negative prognostic marker correlated with a shorter progression-free survival in stage I colorectal carcinoma, but not in the remaining TNM stages. If our findings are confirmed in more extensive analyses on stage I colorectal carcinoma, NGAL assessment may be used in order to select those patients with a higher progression risk and to submit them to adjuvant therapies useful to prevent adverse outcome
Angiogenesis in meningiomas
No full textNeoangiogenesis has been correlated to biological aggressiveness and an adverse clinical course of several neoplasias. Its prognostic role in meningiomas appears to be controversial. Nonetheless, if adequately quantified with specific markers and appropriate scoring methods, angiogenesis seems to be significantly associated with a high growth fraction, development of recurrences and shorter overall survival of meningiomas. As a consequence, neoangiogenesis may represent a target for therapies aimed at reducing the growth of inoperable meningiomas or recurrence risk of totally resected tumors. Even more significantly, the identification of the factors that mediate angiogenesis in meningiomas could help us to determine appropriate novel anti-angiogenic therapies for these tumors. Herein the methods for quantification of angiogenesis as well as its regulating factors in meningiomas are reviewed
Correlative evidence that tumor cell-derived caveolin 1 mediates angiogenesis
No full textno abstract availabl
Evaluation of neo-angiogenesis in a case of chordoid meningioma
No full textChordoid is a rare variant of meningioma that displays a high recurrence rate. In this study we evaluated the immunohistochemical expression of factors that regulate the neo-angiogenesis process in a case of chordoid meningioma with an adverse clinical course. A high microvessel density (MVD), as well as high VEGF and VEGF-R1 expression, was encountered in this tumor. By contrast, the anti-angiogenic factor semaphorin3A, highly expressed in this chordoid meningioma, was ineffective because of the absence of its receptor neuropilin-1. We suggest that VEGF expression and MVD may represent significant prognostic factors in chordoid meningiomas
Meningioma with zellballen growth pattern: histological and immunohistochemical findings
No full textno abstract availabl
HOXB13 is not expressed in pleomorphic giant cell carcinoma of the bladder
No full textThe paper describes the utility of HOXB13 in distinguishing prostatic vs urothelial origin of pleomorphic carcinoma
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