69 research outputs found
Отзыв на монографию Ю.Г. Аляева, В.Е. Синицына, Н.А. Григорьева «Магнитно-резонансная томография в урологии»
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A.V. Matveyev, V.E. Bordon, L.A. Nechiporenko. Technogenic Contamination of Cover Deposits along Automobile Roads in Belarus
No full textПо данным приближенно-количественного спектрального анализа образцов, отображенных на 19 ключевых участках, установлено загрязнение покровных отложений в придорожных полосах Zr, Pb, Mn, Cu, Ti, Ni, Cr, V, изредка Ba, P, B. Максимальная концентрация элементов-контаминантов при-урочена к полосе 40–80 м от полотна дороги. Распределение техногенных примесей довольно неравно-мерное, зависит от интенсивности движения автотранспорта и ряда других причин, на локальных участ-ках содержание элементов может превышать ПДК
Place Names of the Pelym River Area on Antal Reguly’s Handwritten Maps and the Etymologization of Mansi Toponyms
No full textThe article analyses toponymic data from the handwritten maps made in 1844–1845 by the outstanding Hungarian ethnographer and explorer Antal Reguly, that he later used as a basis for his famous Ethhnographic Map of the Northern Ural (1846). Reguly’s handwritten maps, still understudied, contain valuable toponymic information, considerably more detailed than in the final map, which makes them an important source of unique data on the toponymy of the region’s peoples in the 19th century. Based on previous research in the Pelym River toponymy (works by G. P. Vuono, G. V. Glinskikh, A. K. Matveyev), the materials of the explorations of G. F. Müller (1742), B. Munkácsi (1888–1889) and A. Kannisto (1901–1906), the fieldwork materials of the Ural University Toponymic Expedition, collected in 1960s–1970s, as well as on contemporary maps of the region, the author provides etymological interpretations of several toponyms of the Pelym River area whose Mansi population became completely Russified by the mid-20th century. The data retrieved from Antal Reguly’s maps serve to confirm the reliablity of previously suggested etymologies, to specify some of them, and to reconstruct the names that earlier failed to be etymologised
Factor V anticoagulant cofactor activity that targets the early phase of coagulation
No full textTissue factor pathway inhibitor (TFPI), the main inhibitor of initiation of coagulation, exerts an important anticoagulant role through the factor Xa (FXa)-dependent inhibition of tissue factor/factor VIIa (FVIIa). Protein S is a TFPI cofactor, enhancing the efficiency of FXa inhibition. TFPI can also inhibit prothrombinase assembly by directly interacting with coagulation factor V (FV) which has been activated by FXa. Since full-length TFPI associates with FV in plasma, we hypothesized that FV may influence TFPI inhibitory function. Using pure component FXa inhibition assays, we found that while FV alone did not influence TFPI-mediated FXa inhibition, it further enhanced TFPI in the presence of protein S, resulting in an ~8-fold reduction in Ki compared with TFPI alone. A FV variant (R709Q/R1018Q/R1545Q, FVΔIIa) that cannot be cleaved/activated by thrombin or FXa, also enhanced TFPI-mediated inhibition of FXa ~12-fold in the presence of protein S. In contrast, neither activated FV (FVa) nor recombinant B-domain-deleted FV could enhance TFPI-mediated inhibition of FXa in the presence of protein S, suggesting a functional contribution of the B domain. Using TFPI and protein S variants we show further that the enhancement of TFPI-mediated FXa inhibition by protein S and FV depends on a direct protein S/TFPI interaction and that the TFPI C-terminal tail is not essential for this enhancement. In FXa-catalyzed prothrombin activation assays, both FV and FVΔIIa (but not FVa) enhanced TFPI function in the presence of protein S. These results demonstrate a new anticoagulant (cofactor) function of FV that targets the early phase of coagulation before prothrombinase assembly
Роль сорафениба (Нексавар) в лечении неоперабельного местно-распространенного и диссеминированного почечно-клеточного рака
No full textEfficacy and safety issues of sorafenib (Nexavar) use in the treatment of patients with inoperable locally advanced and disseminated renal cell cancer are addressed. Several clinical studies of efficacy of treatment with sorafenib both in mono-regimen and combined with other drugs are discussed.
The Upper Lozva River and Its Adjacent Territories Toponymy on the Handwritten Map by Antal Reguly (Karte NRO I. 1844)
No full textIn the Hungarian Academy of Sciences Archives, there are five numbered plans of maps made by Antal Reguly during his trip to the Northern-Ural Mountains in 1844-1845. Based on the above-mentioned manuscripts, Reguly drew the first detailed map of the Northern-Ural Region in Saint Petersburg in 1846. The first plan of the map (Karte Nro I. 1844) presents the Upper-Lozva River, where he began collecting linguistic materials from the Mansi people of the Region, containing 176 toponyms not only from the Upper-Lozva River but from the Upper-Sosva, Southern-Sosva, Upper-Pelim, Upper-Vishera regions as well as from the western part of the Northern-Ural Mountains. The author lists and analyzes the toponyms from the plan in question considered the first comprehensive source of toponymy of the Region, all the 176 units being analyzed etymologically and compared with the materials collected and etymologized by A. K. Matveyev. In addition to the 69 previously known etymologies, the author offers about 100 new etymological interpretations based on the materials of the manuscript.В архиве Венгерской академии наук хранятся пять планов карт, составленных Анталом Регули во время его путешествия на Северный Урал в 1844–1845 гг. Основываясь на этих рукописях, в 1846 г. в Санкт-Петербурге Регули составил первую подробную карту Северного Урала. Первый план карты (карта № 1, 1844 г.) описывает верхнее течение р. Лозьва, где Регули начал собирать лингвистические материалы у манси этого региона. На ней отмечено 176 топонимов. Это названия не только верхней Лозьвы, но также районов верхней Сосьвы, Южной Сосьвы, верхнего Пелыма, верхней Вишеры и западного склона Северного Урала. В данной статье автор приводит и анализирует топонимы карты № 1 как первого подробного источника топонимии этого региона. 176 топонимов анализируются с этимологической точки зрения в сравнении с материалами, собранными и проэтимологизированными А. К. Матвеевым. Кроме 69 ранее известных этимологий, автор предлагает около 100 новых интерпретаций топонимов, основываясь на материалах рукописи.Автор выражает искреннюю благодарность профессору Т. Н. Дмитриевой за критическое прочтение рукописи
Цитогенетические исследования при двустороннем раке почек
No full textAim. To study chromosomal abnormalities in bilateral renal cell carcinoma (RCC).Materials and methods. Paraffin-embedded specimens from 8 patients with bilateral RCC were examined by comparative genomic hybridization.Results. 1 to 6 chromosomal aberrations were found in each sample. The same chromosomal aberrations in both tumors in 7 (87.5%) cases chromosomal changes were different in one (12.5%) case.Conclusion. Further genetic studies of bilateral RCC may give a better insight into the biology, diagnosis, and treatment of bilateral RCC.
Ангиомиолипома почки: диагностика и лечение
No full textRenal angiomyolipoma (RAML) is a most common benign tumor. It consists of fat, vascular, epithelioid cells, and smooth-muscle elements. Two types are described: isolated RAML and RAML associated with tuberous sclerosis. Tuberous sclerosis-associated RAML accounts for 20% of the tumors; these lesions are typically larger than RAMLs; they are often bilateral and multiple and tend to grow. The adequate diagnostic tools for RAML include ultrasonography and computed tomography. Fine-needle biopsy can elucidate the diagnosis of RAML in difficult cases. Most minor lesions are asymptomatic and those smaller than 5 cm need only a regular follow-up without intervention. Nephronsparing surgery is recommended if large RAMLs or symptomatic lesions are present. In these cases, the optimum treatment is partial nephrectomy or selective renal embolization. Angioembolization of RAML is a new technique which obviates surgical disadvantages. Positive immunoreactivity to HMB-45 and α-smooth muscle actin is diagnostic for RAML and distinguishes it from renal cell carcinoma.
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