1,721,085 research outputs found

    GLI ANALGESICI IN MEDICINA VETERINARIA. Animali da compagnia (fans ed anestetici locali)

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    La gestione del dolore in campo veterinario si basa su terapie con farmaci sistemici e/o locali/regionali. Farmaci antinfiammatori non steroidei, oppioidi, anestetici locali, alfa 2 agonisti e farmaci non convenzionali come la ketamina sono le classi più utilizzate contro il dolore. Questo lavoro descrive brevemente i principi farmacologici delle varie classi in uso nell’analgesia focalizzando concisamente l’attenzione sui singoli farmaci, illustrandone le linee guida generali ed i dosaggi appropriati (ove presenti), descrivendo anche nuove associazioni terapeutiche e/o nuove vie di somministrazione sia sperimentali che cliniche

    GLI ANALGESICI IN MEDICINA VETERINARIA. Animali da compagnia (oppioidi, a2 agonisti e ketamina)

    No full text
    La gestione del dolore in campo veterinario si basa su terapie con farmaci sistemici e/o locali/regionali. Farmaci antinfiammatori non steroidei, oppioidi, anestetici locali, alfa 2 agonisti e farmaci non convenzionali come la ketamina sono le classi più utilizzate contro il dolore. Questo lavoro descrive brevemente i principi farmacologici delle varie classi in uso nell’analgesia focalizzando concisamente l’attenzione sui singoli farmaci, illustrandone le linee guida generali ed i dosaggi appropriati (ove presenti), descrivendo anche nuove associazioni terapeutiche e/o nuove vie di somministrazione sia sperimentali che cliniche

    EVALUATION OF A PLASMA DETECTABLE CONCENTRATION OF TWO LIDOCAINE TRANSDERMAL FORMULATIONS AND THEIR ANALGESIC EFFECT IN THE HORSE

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    Transdermal absorption of four lidocaine (L) patches (5%) was compared with the transdermal absorption of L cream (5%) to evaluate the pharmacokinetics of the two formulations applied on the same anatomic region under dressing in eight horses. The animals were also assessed for antinociceptive effect after removal of the patches and cream, using a psychophysical method visual analog scale, by pricking the patient’s skin to test the response to pain. Horses were randomly assigned to four treatment groups: in groups I and II, four L patches were applied for a period of 24 hours with and without alcohol precleaning, respectively; in group III, 5% L cream was applied every 2 hours over a 24-hour period on the same anatomic site. Group IV was the control. No clinical side effects were noted with either formulation. L was detectable in plasma 6 to 24 hours after application of the patches, and the highest plasma concentrations were reached between 12 and 18 hours. The use of alcohol to preclean the skin appeared to reduce the transdermal drug absorption over time. After L cream application, the peak plasma drug concentration occurred at 24 hours. Nociception assessment after L patch or L cream application showed a decreased response when the L cream was used. The results of this study showed that there was minimal absorption from the L patches compared with the L cream in horses. Also, the L cream treatment reduced significantly the intensity of nociception quality as measured by the visual analog scale

    GLI ANALGESICI IN MEDICINA EQUINA

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    La gestione del dolore in campo veterinario si basa su terapie con farmaci sistemici e/o locali/regionali. Farmaci antinfiammatori non steroidei, oppioidi, anestetici locali, alfa2 agonisti e farmaci non convenzionali come la ketamina sono le classi più utilizzate contro il dolore. Questo lavoro descrive brevemente i principali farmaci impiegati nell’analgesia equina, illustrandone le linee guida generali ed i dosaggi appropriati (ove presenti), descrivendo anche nuove associazioni terapeutiche e/o nuove vie di somministrazione sia sperimentali che cliniche

    Bioremediation and monitoring of aromatic-polluted habitats.

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    Bioremediation may restore contaminated soils through the broad biodegradative capabilities evolved by microorganisms towards undesirable organic compounds. Understanding bioremediation and its effectiveness is rapidly advancing, bringing available molecular approaches for examining the presence and expression of the key genes involved in microbial processes. These methods are continuously improving and require further development and validation of primer- and probe-based analyses and expansion of databases for alternative microbial markers. Phylogenetic marker approaches provide tools to determine which organisms are present or generally active in a community; functional gene markers provide only information concerning the distribution or transcript levels (deoxyribonucleic acid [DNA]- or messenger ribonucleic acid [mRNA]- based approaches) of specific gene populations across environmental gradients. Stable isotope probing methods offer great potential to identify microorganisms that metabolize and assimilate specific substrates in environmental samples, incorporating usually a rare isotope (i.e., 13C) into their DNA and RNA. DNA and RNA in situ characterization allows the determination of the species actually involved in the processes being measured. DNA microarrays may analyze the expression of thousands of genes in a soil simultaneously. A global analysis of which genes are being expressed under various conditions in contaminated soils will reveal the metabolic status of microorganisms and indicate environmental modifications accelerating bioremediation

    Il compostaggio

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