10 research outputs found
Aplicaciones de la informática en el estudio de productos naturales
No full textEn este artículo resumimos y actualizamos los principales conocimientos acerca de los métodos utilizados por la bioinformática y brindamos algunos ejemplos de sus contribuciones en distintos campos. Enfatizamos en el diseño y descubrimiento de nuevas drogas de origen natural, principalmente antimicrobianas. En este sentido, la búsqueda de nuevos medicamentos y estrategias farmacológicas está plenamente justificada por distintas razones, que incluyen la emergencia de resistencia e interacciones farmacológicas, particularmente en pacientes inmunocomprometidos.Fil: Barceló, S. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología. Buenos Aires, Argentina.Fil: Miozza, V. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología. Buenos Aires, Argentina.Fil: Passero, P. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología. Buenos Aires, Argentina.Fil: Farah, E. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología. Buenos Aires, Argentina.Fil: Pérez, C. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología. Buenos Aires, Argentina
Analysis of vegetation distribution in relation to surface morphology: the case study of Miozza and Cetus catchments
No full textIncrease nitric oxide synthase activity in parotid glands from rats with experimental periodontitis
No full textOBJECTIVE: In this study we investigated the activity of the nitric oxide synthase (NOS) in parotid glands from rats with experimental periodontitis and controls. METHODS: Periodontitis was produced by a ligature placed around the cervix of the two lower first molar. Experiments were carried out 22 days after the ligature. RESULTS: Ligation caused an increase in parotid NOS activity. The selective blocker of the inducible isoform of the enzyme partially inhibited its activity in parotid glands from rat with ligature. In controls, the activity was partially inhibited by the antagonists of the selective neural and endothelial isoforms. NOS activity in rats with ligature was cyclic adenosine monophosphate (cAMP)-dependent while in controls it was calcium-dependent. Prostaglandin E₂ concentration was increased in parotid gland from rats with ligature. The inhibitor of prostaglandin production, FR 122047, diminished both, prostaglandin production and NOS activity. In rats with ligature unstimulated amylase released is increased. Both, prostaglandin and NOS were involved in the increment of amylase release. CONCLUSION: It can be concluded that in parotid glands from ligated rats, prostaglandin E₂ production is increased and, through cAMP accumulation, activates the inducible NOS isoform. The increment of nitric oxide production participates in the increase in basal amylase release.Fil: Miozza, V.. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaFil: Borda, Enri Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaFil: S-Borda, L.. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaFil: Busch, L.. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentin
Scelta di materiali per la realizzazione di componenti utilizzati nella trasmissione di potenza con acqua.
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WiZard Si-W imaging calorimeter: a preliminary study on its particle identification capability during a balloon flight in 1993
No full textThe WiZard Collaboration is engaged in a program to study the antimatter components of the cosmic rays. A silicon-tungsten (WiW) imaging calorimeter has been developed as part of this program. We present its performance and preliminary results, obtained during a balloon flight on September 8, 1993. The flight was dedicated to the measurement of the positron spectrum in the energy range 4–50 GeV and took place from Ft. Sumner, New Mexico
WIZARD SI-W IMAGING CALORIMETER - A PRELIMINARY-STUDY ON ITS PARTICLE IDENTIFICATION CAPABILITY DURING A BALLOON FLIGHT IN 1993 RID G-6769-2011
No full textThe WiZard Collaboration is engaged in a program to study the antimatter components of the cosmic rays. A silicon-tungsten (Si-W) imaging calorimeter has been developed as part of this program. We present its performance and preliminary results, obtained during a balloon flight on September 8, 1993. The flight was dedicated to the measurement of the positron spectrum in the energy range 4-50 GeV and took place from Ft. Sumner, New Mexico
