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2. Genetic prothrombotic factors in children with otogenic lateral sinus thrombosis: five case reports
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Genetic prothrombotic factors in children with otogenic lateral sinus thrombosis: five case reports
Author(s): Zangari, P (Zangari, Paola)1; Messia, V (Messia, Virginia)1; Viccaro, M (Viccaro, Marika)2; Bottero, S (Bottero, Sergio)2; Randisi, F (Randisi, Francesco)3; Marsella, P (Marsella, Pasquale)2; Luciani, M (Luciani, Matteo)4; Locatelli, F (Locatelli, Franco)4
Source: BLOOD COAGULATION & FIBRINOLYSIS Volume: 23 Issue: 2 Pages: 158-163 DOI: 10.1097/MBC.0b013e328349cafb Published: MAR 2012
Times Cited: 0 (from Web of Science)
Cited References: 20 [ view related records ] Citation Map
Abstract: Lateral sinus thrombosis (LST) is an uncommon, but life-threatening complication of both acute and chronic otitis media. There is some evidence that acquired or hereditary prothrombotic disorders are risk factors for LST. The aim of this work was to evaluate the role of thrombotic screening, anticoagulant therapy or prophylaxis in patients with either acute or chronic otitis media and LST. The medical records of five children hospitalized at Pediatric Hospital Bambino Gesu of Rome because of acute or chronic otitis media complicated by mastoiditis and LST were reviewed. All children underwent laboratory workup for hypercoagulability. All the five children were found to be heterozygote for the C677T MTHFR mutation and a child presented also heterozygosity for factor V Leiden mutation. They have been successfully treated with anticoagulant therapy without sequels. Children with acute or chronic otitis media may have a prothrombotic tendency that becomes clinically evident because of the inflammatory state. Patients with a family and/or personal history of thrombosis and/or thrombophilic conditions need anticoagulant prophylaxis also in the absence of clear signs of LST. Treatment with low molecular weight is successful in patients with LST. Blood Coagul Fibrinolysis 23:158-163 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
CAP4KAM_nDOF: Computer-Assisted Proofs of existence of KAM tori in Hamiltonian systems with n (>=2) Degrees Of Freedom
No full textIn the folder you can produce by uncompressing the attached zippedfile (namely, that folder is called "CAP4KAM_nDOF"), you should findeverything you need in order to perform a complete computer-assistedproof of existence of invariant tori for a Hamiltonian that satifiesthree assumptions: (i) it describes a (Hamiltonian) system with n>=2 degrees of freedom and its canonical coordinates are n pairs of action-angle variables; (ii) it is close enough to a Kolmogorov normal form (so fulfilling also both the non-resonance and the non-degeneracy conditions usually adopted in the framework of KAM theory); (iii) its expansion in Taylor series (with respect to the actions) is finite, while its Fourier expansions (in the angles) can be infinite.The software included in the present folder "CAP4KAM_nDOF" is anextension of a first public release that was a sort of supplementarymaterial of the paper [VL], i.e.,Locatelli, Ugo (2021), “CAP4KAM2D: Computer-Assisted Proofs Fordemonstrating the existence of 2-Dimensional KAM tori”, MendeleyData, V1, doi: 10.17632/jdx22ysh2s.1The software included in the folder "CAP4KAM_nDOF" is designed tobe in a "easy-to-use" layout. Moreover, it is probably not too difficultto be modified for people expert in programming (in C).Everything about the files included in the folder "CAP4KAM_nDOF" iswidely described in the README.txt, that contains also carefulexplanations that should be useful for running the codes, monitoringthe results, modifying the input files, etc.Eventual corrections or remarks about the software package includedin the folder "CAP4KAM_nDOF" are more than welcome and can besent to the author (Ugo Locatelli) at the following e-mail address: [email protected]
Jean Tardieu, père et artiste. Entretien avec Alix Turolla-Tardieu
No full textInterview of Alix Turolla-Tardieu, the daughter of the poet and author Jean Tardieu
UNITY-Locatelli Meeting Notes
No full textTyped document titled 'UNITY-Father Locatelli Meeting 4/14/89.' Document includes five numerical bullets with agenda items the include an introduction/welcome; history of UNITY; information regarding UNITY "today"; demands; and a session titled 'Open for discussion.' Documents features handwritten notes in black ink. Document does not specify author of agenda or notes
In riferimento al quesito allevatore-produttore agricolo : vendita latte attraverso distributore automatico
No full textElectroreductive dehalogenation: crossroads for waste detoxification and conversion to valued compounds
No full textThe environmental impact of halogenated organic compounds is bound to their present (and past) use in a wide variety of industrial and civil applications, thanks to the wide spectrum of their physical and chemical properties, which, in turn, are at the basis of the assessed risks connected with their persistency and rapid dissemination in soils, water- and air-streams.
An integrated approach for environmental remediation and protection requests both long-term activities devoted to eradicate the risks, and immediate actions to drastically abate the toxicity of the actual wastes while controlling the treatment costs.
In this complex context, the electrochemical technologies can play a key role in terms not only of detoxification efficiency, but also of energy/cost saving and earning potentialities.
The exploitation of these technologies for the electroreductive (hydro)dehalogenation of organic halides is discussed in terms of the recent advances [1-5] on the preparation of cathode materials, reactor design, and investigation tools/methodologies (e.g. C-ME and FEXRAV [3,6]) purportedly developed to characterize both the reaction pathways and the process performances.
[1] O. Lugaresi, H. Encontre, C. Locatelli, A. Minguzzi, A. Vertova, S. Rondinini, Ch.
Comninellis, Electrochem. Commun. submitted
[2] O. V. Klymenko, O. Buriez, E. Labbè, D.-P. Zhan, S. Rondinini, Z.-Q. Tian, I. Svir,
Ch. Amatore, ChemElectroChem 2014, 1, 227-240
[3] A. Minguzzi, C. Locatelli, O. Lugaresi, A. Vertova, S. Rondinini, Electrochim.
Acta 2013, 114, 637-642
[4] O. Lugaresi, A Minguzzi, C Locatelli, A. Vertova, S. Rondinini, Ch. Amatore,
Electrocatalysis 2013, 4, 353-357
[5] A. Minguzzi, O. Lugaresi, G. Aricci, S. Rondinini, A. Vertova, Electrochem.
Commun. 2012, 22, 25-28
[6] A. Minguzzi, O. Lugaresi, C. Locatelli, S. Rondinini, F. D’Acapito, E. Achilli, P.
Ghigna, Anal. Chem. 2013, 85, 7009−
Tempi di attesa nella stalla di sosta prima dell'inizio delle operazioni di macellazione : veterinario garante della salute umana
No full textPERCHLORATES AS POWERFUL CATALYSTS IN MANY IMPORTANT ORGANIC TRANSFORMATIONS
No full textFor long times, metallic perchlorates have been considered dangerous compounds[1] in that they function as explosives and as incontrollable oxidizers.
Therefore, the fear of the great hazard connected with their manufacture and uses had prevented an extensive use both in research laboratories and in industrial processes.[2]
However, recently it has been cleared that this bad reputation is due to the mistaken association of metallic perchlorates with the oxidizing potential of perchloric acid and the pyrotechnic performances of NH4ClO4.
In this conference, we report that Magnesium and Zinc perchlorates can be used as powerful Lewis acids in several organic transformations which are commonly employed both in laboratory and industrial processes.
As depicted in the Scheme, perchlorates are able to promote a series of reactions such as:
a) Acylation of alcohols[3,4]
b) Fisher esterification[5]
c) Synthesis of b–enamino esters[6]
d) Protection of the amino group as N-Boc derivative[7]
Moreover, they can act as specific catalysts for the development of a new organic transformations. In fact, the treatment of an alcohol or a phenol with Boc2O in the presence of Mg(ClO4)2 leads to the unexpected formation of the corresponding t-butyl ethers.[8] This represents the first general method to synthesize aromatic t-butyl ethers.
In an analogous manner, the treatment of phenols with diethyl dicarbonate results in a very efficient method to produce difficulty available aryl ethyl carbonates.
Several of the above mentioned transformations can be carried out in the absence of the solvent, and often the catalyst can be easily recovered and reused without an appreciable loss of activity.
Acknowledgement
Work carried out in the framework of the National Project “Stereoselezione in Sintesi Organica. Metodologie e Applicazioni” supported by MIUR, Rome, by the University of Bologna, in the framework of “Progetto di Finanziamento Pluriennale, Ateneo di Bologna”, and by National project FIRB “Progettazione, preparazione e valutazione biologica e farmacologica di nuove molecole organiche quali potenziali farmaci”
References
[1] Schumacher, J. C. Perchlorates-Their Properties, Manufacture and Uses, ACS Monograph Series, Reinhold: New York, 1960.Author. Title[J]. Name of the journal, Year, Volume(Issue): initial page and ending page (Optional).
[2] Long, J. Chemical Health & Safety, 2002, 9, 12.
[3] Bartoli, G.; Bosco, M.; Dalpozzo, R.; Marcantoni, E.; Massaccesi, M.; Rinaldi, S.; Sambri, L. Synlett, 2003, 39.
[4] Bartoli, G.; Bosco, M.; Dalpozzo, R.; Marcantoni, E.; Massaccesi, M.; Sambri, L. Eur. J. Org. Chem. 2003, 4611.
[5] a) Gooβen, L.; Döhring, A. Adv. Synth. Catal. 2003, 345, 943; b) Bartoli, G.; Boeglin, J.; Bosco, M.; Locatelli, M.; Massaccesi, M.; Melchiorre, P.; Sambri, L. Adv. Synth. Catal. 2005, 347, 33.
[6] Bartoli, G.; Bosco, M.; Locatelli, M.; Marcantoni, E.; Melchiorre, P.; Sambri, L. Synlett 2004, 239.
[7] Bartoli, G.; Bosco, M.; Locatelli, M.; Marcantoni, E.; Massaccesi, M.; Melchiorre, P.; Sambri, L. Synlett 2004, 1794.
[8] Bartoli, G.; Bosco, M.; Locatelli, M.; Marcantoni, E.; Melchiorre, P.; Sambri, L. Org. Lett., 2004, 7, 427
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