94 research outputs found
The Primary Sclerosing Cholangitis (PSC) Wellbeing Study: Understanding psychological distress in those living with PSC and those who support them
Get PDFIntroduction The impact of living with Primary Sclerosing Cholangitis (PSC) on psychological wellbeing is not well-known. A recent scoping review by the authors found that both depression and anxiety frequently featured in the accounts of those living with the illness. However, less clear were the factors that led to such psychological distress, the impact that the illness had on families and how to best support those living or supporting someone living with the illness. In light of this, the aim of this study was to explore how the illness impacted the lives of both those diagnosed with the illness and those supporting them. Method and results This study adopted a phenomenological approach to understand the subjective experiences of individual participants. A total of 30 individuals took part in Asynchronous Virtual Focus Groups hosted on a Virtual Learning Environment for a four-week period. Chronological narratives of individuals’ lived experiences from diagnosis to post-transplant are presented below. These narratives centred upon individuals’ and families’ experiences of receiving a diagnosis, and adjusting to life post-diagnosis, particularly in regard to their relationships with health professionals and other family members, and in preparing for the possibility of transplant. Discussion The present article provides an in-depth look at how PSC can impact psychological wellbeing, how psychological distress arises and includes advice tailored to individuals, families and health professionals on how to best support each other
RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ASPIRIN, RAMIPRIL, HYDROCHLOROTHIAZIDE, SIMVASTATIN AND ATENOLOL FROM PHARMACEUTICAL DOSAGE FORM
Get PDFObjective: The present study was designed with an objective of a simple, fast, precise, selective and accurate RP-HPLC method was developed and validated for the simultaneous determination of Aspirin, Ramipril, Hydrochlorothiazide, Simvastatin and Atenolol from bulk drug and formulation.Methods: The separation was achieved on a Hypersil Gold column (250 mm X 4.6 mm, 5 µ) as stationary phase with a mobile phase consisting of methanol: water in the ratio of 95:5% v/v at a flow rate of 1 mL/min and UV detection at 230 nm.Results: The retention times were observed to be 1.983, 2.525, 3.108, 3.867 and 7.833 minutes for Aspirin, Ramipril, Hydrochlorothiazide, Simvastatin and Atenolol, respectively. The method was statistically validated for linearity, recovery, the limit of detection, limit of quantification, accuracy and precision.Conclusion: Thus, proposed method was found sensitive, precise, accurate and specific and be used for quantitative estimation of Aspirin, Ramipril, hydrochlorothiazide, Simvastatin and Atenolol in commercial pharmaceutical dosage form.Â
USE OF MICELLAR MOBILE PHASE FOR THE CHROMATOGRAPHIC SIMULTANEOUS DETERMINATION OF ATENOLOL AND INDAPAMIDE IN PHARMACEUTICAL DOSAGE FORM
No full textRapid liquid chromatographic procedure has been developed for the simultaneous determination of Atenolol and Indapamide in a bulk drug and pharmaceutical formulation. The method uses C18 stationary phases and micellar mobile phases of 0.07M sodium dodecyl sulfate (SDS) pH 3 adjusted with phosphate buffer and 15 % (v/v) 1- propanol as organic modifier and ultraviolet detection at 229 nm are used for the determination. Under these conditions, the studied indapamide and atenolol elute between 5.59 ± 0.10 and 8.058 ± 0.034 min at a 1.5 mL/min flow rate. Limits of detection are well below the concentrations of the drugs found in the commercial pharmaceutical preparation analyzed. The recoveries of the analytes in the pharmaceutical preparations are in the range 99.59 to 99.96 % for atenolol and 99.03 to 99.14 % for indapamide, respectively
A unified method to solve the energy depletion and congestion problem using mobile relay in manets
No full text
REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF DICYCLOMINE HYDROCHLORIDE, PARACETAMOL AND MEFENAMIC ACID IN BULK AND TABLET DOSAGE FORM
No full textABSTRACTObjective: The objective of this study was to develop and validate a simple, precise and accurate reverse phase high performance liquid chromatographicmethod for simultaneous estimation of dicyclomine hydrochloride, paracetamol, and mefenamic acid from multicomponent tablet dosage form.Methods: The optimized chromatographic separation was achieved using a stationary phase of hypersil gold ODS- C18 (250 × 4.6 mm i.d, 5 μmparticle size) column and mobile phase of acetonitrile: Methanol: Potassium dihydrogen phosphate buffer, pH adjusted to 4.5 with orthophosphoricacid (OPA) in the ratio of 50: 30: 20 (v/v/v) with a flow rate of 1 mL/minute. The ultraviolet detection was carried out at 260 nm.Results: The retention times of paracetamol, dicyclomine hydrochloride and MEF were found to be 4.2, 6.1 and 3.4 minutes, respectively. The methodwas validated for linearity, precision, accuracy, and robustness. The developed method provided linear responses within the concentration ranges2-12 μg/mL for dicyclomine hydrochloride, 50-300 μg/mL for paracetamol, and 25-150 μg/mL for MEF. The % recovery obtained were found to be99.09-99.44% for dicyclomine hydrochloride, 99.22-99.51% for paracetamol, and 99.49-99.60 for MEF.Conclusion: The proposed method enables rapid quantification and simultaneous analysis of all the drugs from commercial formulations without anyinterference of excipients. Hence, the developed method can be successfully applied for routine analysis of dicyclomine hydrochloride, paracetamol,and MEF in their combined tablet formulation.Keywords: Dicyclomine hydrochloride, Paracetamol, Mefenamic acid, High performance liquid chromatography</jats:p
RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF LOSARTAN, HYDROCHLOROTHIAZIDE AND AMLODIPINE IN TABLET DOSAGE FORM
Get PDFObjective: The present study was designed with an objective of a simple, fast, precise, selective and accurate RP-HPLC method was developed and validated for the simultaneous determination of Losartan, Hydrochlorothiazide and Amlodipine from bulk and formulations.
Methods: Reverse phase high performance liquid chromatography (RP-HPLC) method was developed and validated for rapid analysis of simultaneous determination of Losartan, Hydrochlorothiazide and Amlodipine. The separation of these three drugs was achieved on a Hypersil Gold column (250 mm X 4.6 mm, 5 µ) as stationary phase with a mobile phase consisting of methanol: water in the ratio of 95:5percent v/v at a flow rate of 0.8 mL/min and UV detection at 230 nm.
Results: The retention times were observed to be 2.850, 3.875 and 7.333 minutes for Losartan, Hydrochlorothiazide and Amlodipine, respectively. The method was statistically validated for linearity, recovery, limit of detection, limit of quantification, accuracy and precision.
Conclusion: The method was successfully applied for analysis of combined dose tablet formulation containing Losartan, Hydrochlorothiazide and Amlodipine.
Â
Keywords:Â Amlodipine, hydrochlorothiazide, losartan, reverse phase high performance liquid chromatography
Adsorption studies of chromium (VI) on weak base resins Tulsion A-10X (MP) and Amberlyst A-21 (MP) in aqueous and mixed media
No full text- …
