4,284 research outputs found
Cell-cycle molecules in mesothelioma
No full textThe cell cycle is the cascade of events that allows a growing cell to duplicate all its component and split into two daughter cells. Several studies report the importance of cell cycle proteins in the pathogenesis and the prognosis of mesothelioma. Cell cycle progression is mediated by the activation of a highly conserved family of protein kinases, the cyclin-dependent kinases (CDKs). CDKs are also regulated by related proteins called cdk inhibitors grouped into two families: the INK4 inhibitors (p16, p15, p19 and p18) and the Cip/Kip inhibitors (p21, p27 and p53). This article will review the most recent data from the literature about the expression and the diagnostic and prognostic significance of cell cycle molecules in mesothelioma
Il Carcer nella produzione di Cardano
No full textAlongside a larger analysis of Cardano's moral philosophy since the De consolatione (1542), the essay focuses on the dialogue Carcer, and suggests a relationship between the difficulties encountered by the author in the Duchy of Milan in 1560-61, and the trial of 1570 in Bologna. Special attention is devoted to the philosophical reasons that support in the Carcer the Plutarchean sera numinis vindicta, one of Cardano's favorites topics
Comparing three possible hypoelliptic Laplacians on the 5-dimensional Cartan group via div-curl type estimates
No full textOn general Carnot groups, the definition of a possible hypoelliptic Hodge-Laplacian on forms using
the Rumin complex has been considered in (M. Rumin, “Differential geometry on C-C spaces and application
to the Novikov-Shubin numbers of nilpotent Lie groups,” C. R. Acad. Sci., Paris Sér. I Math., vol. 329, no. 11, pp.
985–990, 1999, M. Rumin, “Sub-Riemannian limit of the differential form spectrum of contactmanifolds,” Geom.
Funct. Anal., vol. 10, no. 2, pp. 407–452, 2000), where the author introduced a 0-order pseudodifferential operator
on forms. However, for questions regarding regularity for example, where one needs sharp estimates, this
0-order operator is not suitable. Up to now, there have only been very few attempts to define hypoelliptic Hodge-
Laplacians on forms that would allow for such sharp estimates. Indeed, this question is rather difficult to address
in full generality, the main issue being that the Rumin exterior differential dc is not homogeneous on arbitrary
Carnot groups. In this note, we consider the specific example of the free Carnot group of step 3 with 2 generators,
and we introduce three possible definitions of hypoelliptic Hodge-Laplacians.We compare how these three possible
Laplacians can be used to obtain sharp div-curl type inequalities akin to those considered by Bourgain &
Brezis and Lanzani & Stein for the de Rham complex, or their subelliptic counterparts obtained by Baldi, Franchi
& Pansu for the Rumin complex on Heisenberg groups
A Framework for Rapid Development and Portable Execution of Packet-Handling Applications
No full textThis paper presents a framework that enables the execution of packet-handling applications (such as sniffers, firewalls, intrusion detectors, etc.) on different hardware platforms. This framework is centered on the NetVM - a novel, portable, and efficient virtual processor targeted for packet-based processing - and the NetPDL - a language dissociating applications from protocol specifications. In addition, a high-level programming language that enables rapid development of packet-based applications is presented
Possession
No full textThis chapter of the Historical Latin Syntax traces the evolution and use of predicative possessive constructions from Archaic to Late Latin. We demonstrate that, far from being merely a so-called “be-language”, Latin is a language where the major possessive type is based on a transitive verb (habeo) since the archaic stage. A textual, contrastive analysis of the habeo x and mihi est x types proves that between these two constructions there is a functional differentiation (i.e. syntactic and pragmatic, while the semantic level is relevant only to a minor extent). This, thus, explains: their different occurrence in the Latin corpus; their division-of-labour and, therefore, their coexistence through the history of Latin; and, finally, the diahronic evolution towards the transitive type. A comparison between the mihi est x and the genitive predicative type, which are fully differentiated on a functional plane, completes the picture of the whole architecture of predicative possession in Latin. Consequences can be drawn on the general plane, as “mixted” types (i.e. languages that are both have- and be-), such as Latin, must be taken into consideration when we approach the typology of predicative possession.
An analysis of attributive constructions is then offered, at the light of parameters such as: the order of the elements in the sequence, the definite status of the possessor/possessum constituents of the phrase, the semantic profile of the relation expressed, and the different morphological markers, etc.. Conclusions partly confirm previous hypotheses about the relation between the Latin stage and the Indoeuropean stage, while several generalizations from the typological point of view have to be adjusted (e.g. external possessor constructions).
The part on predicative possession is mainly due to Andrea Nuti; the part on attributive possession mainly to Philip Baldi. However, as the whole chapter is the result of a deep, mutual work carried on in full cooperation, the authors have agreed not to state explicitly and neatly an author-to-pages correspondence
Quasi-periodic solutions of the equation v_tt - v_xx + v^3 = f(v)
No full textWe consider 1D completely resonant nonlinear wave equations of the type vtt - vxx = -v3 + O(v4) with spatial periodic boundary conditions. We prove the existence of a new type of quasi-periodic small amplitude solutions with two frequencies, for more general nonlinearities. These solutions turn out to be, at the first order, the superposition of a traveling wave and a modulation of long period, depending only on time
Forum Non Conveniens and Transnational Litigations on Business and Human Rights: The English Court of Appeal's Decision in Limbu v. Dyson
No full textThis article examines the recent decision by the Court of Appeal of England and Wales, which rejected the application of the "forum non conveniens" doctrine in "Limbu v. Dyson". The case involves claims brought by Nepalese and Bangladeshi migrant workers alleging forced labour and abusive living conditions at Malaysian factories supplying products and components for Dyson-branded goods. Reversing a previous High Court’s ruling, the Court of Appeal determined that the claims could proceed in England, which was «clearly and distinctly the appropriate forum» to hear the case. In reaching this conclusion, the Court of Appeal gave crucial and overdue consideration to, "inter alia", the major imbalances of power affecting transnational litigation on business and human rights, as well as the role of decision-making (or the lack thereof) by anchor defendants in their place of domicile in establishing the jurisdiction of home state courts. The decision is significant as it appears to reinforce the position of overseas victims of business-related human rights abuses and potentially pave the way for important developments concerning corporate accountability for human rights harms in global supply chains
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