1,722,458 research outputs found
The spectrum of contact allergy in elderly patients with and without lower leg dermatitis
No full textUter W, Geier J, Pfahlberg A, Effendy I. The spectrum of contact allergy in elderly patients with and without lower leg dermatitis. Dermatology. 2002;204(4):266-272.Background. There is a strong influence of lower leg dermatitis on the spectrum of allergic contact sensitivity in elderly patients. Objective: To quantitatively assess the impact of this factor which confounds the age-related pattern of allergic contact sensitivity. Methods: Stratified analysis of allergic contact sensitivity data collected between 1996 and 1999 in the 32 centres of the Information Network of Departments of Dermatology (three age groups: less than or equal to 60, 61-75, greater than or equal to 76 years), both as crude and as directly standardised (for sex and leg dermatitis) proportions. Results: Among the 36,070 patients tested with the German standard series, allergic contact sensitivity to neomycin, lanolin, cetostearylic alcohols, colophony, fragrance mix and balsam of Peru, among others, was (much) more common in the elderly, with proportions more or less affected by standardisation. Conclusion: The comparison of crude and standardised proportions provides evidence that allergic contact sensitivity to several allergens strongly depends not only on age itself, but on age-related and thus confounding co-morbidity. Copyright (C) 2002 S. Karger AG, Basel
Allergic contact dermatitis caused by methylisothiazolinone from a 'waist reduction belt'
No full textThe Glorious Life of Mingo – William Battenby – In Service to Life
No full textAuthor Elizabeth Uter reads her short story about Mingo, a young Black man whom Samuel Pepys encountered in the 1660s. In 1667 Sir William Batten died and left Mingo the rights to staff the navigation lights at Harwich port. This story imagines what happened next...
You can read this work, along with other poetry and prose inspired by Pepys's journal, in the collection Other Lives in Samuel Pepys's Diary, edited by Kate Loveman (https://doi.org/10.25392/leicester.data.20449623)
The collection was produced as part of the ‘Reimagining the Restoration’ project, which is funded by the AHRC.</p
Pengaruh Penambahan Tepung Pisang Uter (Musa Paradisiaca Linn. Van Uter ) Terhadap Karakteristik Yoghurt Sinbiotik Ditinjau Dari Ph, Viskositas, Daya Ikat Air, Dan Sineresis
No full textYoghurt sinbiotik adalah yoghurt yang dibuat dengan menambahkan bakteri probiotik dan dikombinaskan dengan prebiotik yang dapat memberikan sifat fungsional yang lebih baik bagi tubuh. Probiotik adalah bakteri asam laktat yang dapat melawan bakteri patogen dan prebiotik adalah bahan makanan yang tidak dapat diserap tubuh namun dapat menstimulasi pertumbuhan BAL. pH yoghurt menurun karena penambahan BAL dan saat mencapai titik isoelektrik, daya tarik kasein meningkat dan melemahkan daya pengikat air sehingga terjadilah sineresis, hal ini dapat dicegah dengan penambahan stabilizer. Inulin pada tepung pisang uter dapat digunakan sebagai stabilizer. Tujuan dari penelitian ini adalah mengetahui pengaruh penambahan tepung pisang uter yang optimum terhadap karakteristik yoghurt sinbiotik ditinjau dari uji pH, viskositas, daya ikat air, dan sineresis.
Penelitian ini dilaksanakan pada bulan September-November 2023 di Laboratorium Teknologi Hasil Ternak Fakultas Peternakan Universitas Brawijaya. Materi yang digunakan adalah susu sapi segar, tepung pisang uter, starter yang terdiri dari bakteri Lactobacillus bulgaricus, Lactobacillus acidophilus, Streptococcus thermophilus, dan Bifidobacterium. Metode yang digunakan adalah Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan dengan 5 ulangan. Perlakuan penelitian dengan penggunaan tepung pisang uter adalah P0 sebagai perlakuan kontrol tanpa penambahan tepung pisang uter, P1 (2%), P2 (4%), P3 (6%). Data dianalisis menggunakan analisis ragam (ANOVA) jika ada perbedaan nyata atau sangat nyata, selanjutnya dianalisis menggunakan Uji Jarak Berganda Duncan (UJBD).
Hasil menunjukkan nilai rata-rata pH yoghurt sinbiotik P0 (4,4±0,01), P1 (4,29±0,07), P2 (4,16±0,03), P3(4,05±0,05). Nilai rata-rata viskositas P0 (24,44±5,31 mPa’s), P1 (48,06±7,16 mPa’s), P2 (70,58±14,34 mPa’s), P3 (126,48±31,68 mPa’s). Nilai rata-rata daya ikat air P0 (29,76±5,49%), P1 (51,26±3,35%), P2 (70,63±7,67%), P3 (75,58±9,45%). Nilai rata-rata sineresis P0 (68,43±5,75%), P1 (47,79±3,92%), P2 (30,9±4,04%), P3 (23,48±4,11%). Hasil penelitian ini dapat disimpulkan bahwa persentase optimum penambahan tepung pisang uter (Musa paradisiaca Linn. Van Uter) dalam pembuatan yoghurt sinbiotik ditinjau dari pH, viskositas, daya ikat air, dan sineresis yaitu 6%. Yoghurt dengan penambahan tepung pisang uter dapat meningkatkan viskositas dan daya ikat air, serta menurunkan pH dan nilai sineresis pada yoghurt sinbiotik
The epidemiological analysis of contact allergy
No full textFor different reasons, population based epidemiological studies are an exception in the field of contact allergy (CA) research. In this area, the systematic capturing and analysis of clinical "routine data" of patients patch tested, collected in a research network such as the Information Network of Departments of Dermatology (IVDK, www.ivdk.org) offers the opportunity to examine time trends of specific CA, or to identify subgroups with an elevated risk of specific CA. Distinct examples of such time trends include the decline of CA to glyceryl monothioglycolate after withdrawal from the market, of nickel after regulatory initiatives to limit liberation, and of certain fragrance compounds after the issuing of recommendations for lowered use concentrations. The confounding of such results by relevant patient characteristics (e.g. age, gender) needs to be considered. This also holds true for the analyses of risk factors for certain CA, which thus need to be multifactorial and appropriately adjusted. Based on the wealth of data yet accumulated in the IVDK, such analyses have been performed targeting CA to bufexamac, neomycin sulphate, p-phenylenediamine and fragrance mix, among others. In these analyses, "polysensitization" has consistently been identified as eminent risk factor, i.e. the presence of further CA. Possible genetic determinants of this putative phenotypic susceptibility factor are in the present research focus of the IVDK, together with continual and ever refined surveillance, and attempts to improve risk assessment by formal consideration of sufficiently specific information on human exposure to contact allergens
Patch testing with the DKG Baseline Series - a retrospective
No full textThe diagnosis of contact sensitization relies on patch testing. The selection of allergens to be applied is a crucial aspect. In principle, those (and only those) allergens should be tested which can be regarded as suspects based on the individual patients history. However, suspicion does not only rely on individual history. Those allergens which have proven to be frequent sensitizers in large-scale patch test studies may be important in the case in question, too. This is the rationale of the Baseline series. These series are useful to diagnose contact sensitization which was initially not suspected based on the history. The composition of the Baseline series thus depends on the descriptive statistics of the most frequent contact sensitizers. This implies that the composition should adapt to a pattern of allergen exposure which may change over time and which may differ between countries. The Baseline series of the DKG underwent significant changes in the last 20 years. These comprise the inclusion of new allergens, the exclusion of obsolete allergens or the adaption of concentration or vehicle to new evidence. While there is a considerable amount of variation among the allergens included in the Baseline series, a certain set of allergens seems to be of secular importance. Previous and current analyses of the IVDK on the other hand show that the Baseline series only diagnoses about 42% of all contact sensitizations. Thus, in each case the application of additional test series should be contemplated. However, in times of dwindling health care resources it should be stressed that the application of the patch test Baseline series must be considered as the minimal standard and that according to Calnan: "The greatest abuse of patch testing is failure to use it"
The epidemiological analysis of contact allergy
No full textFor different reasons, population based epidemiological studies are an exception in the field of contact allergy (CA) research. In this area, the systematic capturing and analysis of clinical "routine data" of patients patch tested, collected in a research network such as the Information Network of Departments of Dermatology (IVDK, www.ivdk.org) offers the opportunity to examine time trends of specific CA, or to identify subgroups with an elevated risk of specific CA. Distinct examples of such time trends include the decline of CA to glyceryl monothioglycolate after withdrawal from the market, of nickel after regulatory initiatives to limit liberation, and of certain fragrance compounds after the issuing of recommendations for lowered use concentrations. The confounding of such results by relevant patient characteristics (e.g. age, gender) needs to be considered. This also holds true for the analyses of risk factors for certain CA, which thus need to be multifactorial and appropriately adjusted. Based on the wealth of data yet accumulated in the IVDK, such analyses have been performed targeting CA to bufexamac, neomycin sulphate, p-phenylenediamine and fragrance mix, among others. In these analyses, "polysensitization" has consistently been identified as eminent risk factor, i.e. the presence of further CA. Possible genetic determinants of this putative phenotypic susceptibility factor are in the present research focus of the IVDK, together with continual and ever refined surveillance, and attempts to improve risk assessment by formal consideration of sufficiently specific information on human exposure to contact allergens
Contact allergy to acrylates and methacrylates in consumers and nail artists – data of the Information Network of Departments of Dermatology, 2004–2013
No full textBackground. Allergic contact dermatitis caused by (meth) acrylates used in artificial nails is a relevant problem in both nail artists and consumers. Objective. To analyse the frequency of this problem in the contact allergy surveillance network Information Network of Departments of Dermatology in 2004-2013, and address possible time trends and patterns of co-sensitization. Methods. A retrospective analysis of patch test results with (meth) acrylates, along with clinical and demographic data, was performed. These were used to subdivide patients according to (i) a potentially exposed occupation and (ii) nail cosmetics as the suspected cause of contact dermatitis. Results. Among the 114 440 patients patch tested, 72 244 were female and were considered further. Eighty-seven patients both worked as nail artists/cosmetologists and suspected nail cosmetics as the cause of dermatitis. Among these, 47.1% reacted to at least one (meth) acrylate, most often to 2-hydroxyethyl methacrylate (n= 27), 2-hydroxypropyl methacrylate, and hydroxyethyl acrylate (n= 26 each), with marked coupled reactivity. In other subgroups of interest, frequencies of sensitization to (meth) acrylates were less elevated but higher than in all remaining female patients (n= 69 419). Conclusions. The results indicate a not entirely common, but potentially serious, problem, especially concerning occupationally exposed, and sensitized, nail artists. Adequate protective measures should be taught as part of the vocational training
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