1,721,460 research outputs found
TNF-alpha and insulin-resistance: Metabolic effects of in vivo therapeutic blockade
No full textInsulin resistance is a key pathophysiologic feature of obesity, type 2 diabetes mellitus and prediabetic states (impaired fasting glucose, impaired glucose tolerance). TNF-α, a proinflammatory cytokine, plays an important role in the pathogenesis of insulin resistance associated with inflammation during the course of rheumatic diseases. Therapies aimed at neutralizing TNF-α, such as the monoclonal antibody infliximab, represent a relatively new approach in the treatment of rheumatic diseases and allow to obtain significant results in terms of control of the inflammatory process. In this article we reviewed the scientific evidence published in the literature about a potential role of TNF-α blockade in improving insulin resistance in rheumatic patients without diabetes
Aspetti di pragmatica della comunicazione applicata a testi letterari latini. Il caso di Ovidio
No full textThis paper aims to explore the interpretive possibilities offered by the application of the concepts of pragmatics
of communication and linguistic pragmatics to Ovid’s poetry. Specifically, the interactions between
characters in episodes from the Metamorphoses, the double Heroides and the Fasti are analysed through the
concepts of pragmatic paradox, conversational implicature and implicit narration
Un ipotesto virgiliano per un verso sospetto delle Metamorfosi (6, 674) = A Virgilian Hypotext and a suspected line in the Metamorphoses (6, 674)
No full textL’articolo mostra come il rapporto di intertestualità di Ov. met. 6, 671-674 con Verg. Aen. 9, 731-735 fornisca un forte indizio in favore dell’autenticità del v. 674 del passo ovidiano, più volte sospettato di interpolazione
Melanie Möller (ed.), Gegen / Gewalt / Schreiben. De-Konstruktionen von Geschlechts und Rollenbildern in der Ovid-Rezeption, Berlin, W. de Gruyter, 2021, in «Latomus» 81, 2022, pp. 945-947
No full textRecensione al volume
causam facundo reddidit ore deus – Studien zu den Göttergesprächen in Ovids Fasti, Hamburg 2019
No full textRecensione al volume
Maillard reaction products fulfil chemical and kinetic criteria to behave as chain breaking antioxidants
No full text
The emerging role of complement c3 as a biomarker of insulin resistance and cardiometabolic diseases: Preclinical and clinical evidence
No full textBackground: An intricate network of reciprocal interactions between adipose tissue and immune system have been largely demonstrated, leading to the well-accepted concept of insulin resistance as a low grade inflammatory state and, conversely, chronic high-grade inflammation as a dysmetabolic condition. Immune homeostasis is regulated by several players including the complement system, a complex protein network at the crossroad between the innate and adaptive arms of the human defences against pathogens. Objective: Complement C3 represents the nodal point of the complement cascade independently of the pathway recruited. Aim of this review is to collect the evidence supporting the role of complement C3 as a candidate biomarker of insulin resistance and other metabolic disorders. Method: We reviewed the available evidence pointing to a role of complement system, and in particular complement C3, in insulin resistance and other cardiometabolic diseases including diabetes (T2D), hypertension, non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. Results: Compelling preclinical evidence demonstrated a role of adipose-tissue C3 and its cleavage products C3a and acylation stimulating protein (ASP) in adipose tissue inflammation and insulin resistance. To further support this hypothesis, several clinical studies, both cross-sectional and longitudinal, confirmed this association in independent cohorts. Moreover, preliminary evidence support a role of complement C3 in other cardiometabolic diseases such as hypertension, NAFLD and atherosclerosis. Conclusion: Future studies are needed to fully confirm the usefulness of C3 as a clinical biomarker and to establish accurate cut-off values. Moreover, the therapeutic potential of C3 modulation in either cardiometabolic and inflammatory diseases need to be investigated
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