203 research outputs found
Acute Dependency Reaction to Meperidine: A case report
No full textPostoperative discitis is a rare and painful complication that may emerge following spine procedures. We present a 34-year-old male patient with postoperative discitis who had been addicted to meperidine during pain relief. Three weeks after routine lumbar discectomy, this patient presented with clinical findings and radiographic imaging consistent with discitis. Meperidine, rate of administration was 1 mg/kg three times a day, was prescribed for his low back pain. After two weeks of opioid therapy an iatrogenic meperidine addiction occurred. Opioid analgesics are helpful for excessive painful conditions as a discitis. Although this case showed us we should be careful when we prescribe opioids
Cooperative dancing with an industrial manipulator: Computational cybernetics complexities
No full textTural, Kübra (Dogus Author) -- Tükel, Dilek Bilgin (Dogus Author) -- Conference full title: 2016 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2016; Budapest; Hungary; 9 October 2016 through 12 October 2016.Synchronization of music and dance of industrial manipulators is studied, simulated and realized. The results are shown in this paper. To formulate the dance, a modified Labanotation software has been developed, and a user-friendly human-machine interface is designed to enable the user to program the robot easily. The system is incorporated with a music analyzer, employing Fast Fourier Transform, to track the beats. The robot dances in synchrony with the input from the music analyzer. Experiments are done on a six degree-of-freedom industrial robot
Neurotrophic factors and hippocampal activity in PTSD
No full textAlthough numerous studies have investigated the neurotrophic factors and hippocampal activity in posttraumatic stress disorder (PTSD) separately each other, it is unclear whether an association between neurotrophic factors and hippocampal activity is present. The aim of this study was to evaluate the functional changes in hippocampus before and after treatment with escitalopram and to associate these changes with peptides related to neuronal growth in patients with chronic PTSD and trauma survivors without PTSD. Fifteen earthquake survivors with chronic PTSD and thirteen drug nave trauma exposed individuals without PTSD underwent fMRI scans in a block design. Serum levels of Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF) were measured before and after 12 weeks treatment with escitalopram. Baseline median serum level of NGF was significantly lower in patients with chronic PTSD than trauma survivors; however, 12 weeks of treatment with escitalopram significantly increased it. Higher activation was found both in left and right hippocampus for chronic PTSD group than trauma survivors. Treatment with escitalopram was significantly associated with suppression of the hyperactivation in left hippocampus in patients with chronic PTSD. Bilateral hyperactivation in hippocampus and lowered NGF may associate with neurobiological disarrangements in chronic PTSD. Treatment with escitalopram was significantly associated with both improvement in the severity of PTSD symptoms and biological alterations. Patients diagnosed with PTSD may have further and complicated deteriorations in hippocampal networks and neurotransmitter systems than individuals who had not been diagnosed with PTSD following the same traumatic experience
DOUBLE BLIND CONTROLLED STUDY OF ADDING FOLIC ACID TO FLUOXETINE IN THE TREATMENT OF OCD
No full textBackground: Folate is important for the synthesis of serotonin the neurotransmitter which plays a main role in OCD. We, therefore, explored the efficacy of folic acid as add on treatment to fluoxetine in a double blind study among patients with OCD. Subjects and methods: A double blind, 12-week study comparing the efficacy of folic acid as add on treatment and placebo in patients with OCD was conducted on thirty six (36) patients. Patients were randomly assigned to folic acid (5 mg/day) or placebo group in addition to fluoxetine (40 mg/day). After the baseline assessment, on week 2, 4, 6, 8 and 12 assessments were performed by using YBOCS, HAM-D, HAM-A and CGI-S. Serum folate, erythrocyte folate, serum homocysteine and B-12 levels were measured both baseline and the end of study. Results: A mixed model repeated measures ANCOVA on Y-BOCS scores were used to determine the difference between folic acid and placebo groups. No significant differences were found in the ratios of gender or in the mean age, serum folic acid level, erythrocyte folate level, serum homocysteine level and serum B-12 level between the treatment groups at the baseline. Consecutively scores collected over six measurements on YBOCS, HAM-D, HAM-A and CGI showed non-significant differences between folic acid and placebo groups. Conclusion: None of the biological markers of one carbon metabolism were associated with the change in YBOCS scores. It may be assumed that there is no beneficial effect of folic acid addition to fluoxetine in the treatment of OCD
Proton magnetic resonance spectroscopic analysis of changes in brain metabolites following electroconvulsive therapy in patients with major depressive disorder
No full textObjectives: The aim of this study was to evaluate the metabolic changes in the anterior cingulate cortex (ACC) induced by electroconvulsive therapy (ECT) in patients with MDD via H-1-MRS. Methods: The study was conducted on 13 MDD patients receiving ECT treatment and 14 healthy controls matched in terms of age, gender and education. The patients underwent six sessions of ECT. H-1-MRS imaging and psychometric evaluations obtained before 1st and after the 6th sessions. The control group also went through the same procedures except for ECT. N-Acetyl aspartate (NAA), choline (Cho) and creatine (Cr) metabolite levels and the creatine to metabolite ratios were measured. Results: There was no significant difference in the ACC metabolite levels of the patients and those of the controls at the baseline. ECT associated with a statistically significant decrease in the NAA/Cr ratio in ACC. All of the patients had responded to ECT treatment as measured with the clinical scales. Conclusions: The results has suggested that indirect proof of an increase in energy metabolism without any evidence of impaired neuronal viability in the ACC induced by ECT. The relative increase in Cr levels following ECT in MDD seems to be associated with improvement in clinical severity
The Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol
No full textTwo-way coupled aerodynamics and vehicle dynamics simulations of a heavy ground vehicle subjected to crosswind of various frequencies
No full textThe present study investigates the dynamic characteristics of a heavy ground vehicle subjected to crosswind with various frequencies using two-way coupled simulations between aerodynamics and vehicle dynamics, including the driver's steering inputs. Four different reduced frequencies of crosswind, which are equal to 4.2, 2.1, 1.3 and 0.9, are used. The results show that the absolute maximum magnitudes of the vehicle's lateral dynamic and aerodynamic characteristics increase inversely proportional with the reduced frequencies of crosswinds without the driver's steering input. However, when the driver's steering input is included in the vehicle's response to the crosswind disturbances, the vehicle's lateral dynamic characteristics increase by the largest amount for reduced frequencies of 1.3 and 2.1. Furthermore, for a reduced frequency of 0.9, the driver's steering inputs attenuate the unfavourable amplifications in the vehicle's lateral dynamic characteristics. In the present study, the reasons for the increase in the vehicle's lateral dynamic characteristics in the cases of reduced frequencies equal or greater than 1.3 with the driver's steering input are explained. Additionally, the results show that the vehicle is not controlled within the 0.5 m lateral margins of the road when the steering starts with a time delay of 1.0 s for reduced frequencies equal to or lower than 2.1.Swedish Innovation Agency Vinnova [2017-03391]; Centre for ECO2 Vehicle Design at KTH (Vinnova) [2016-05195]; Vinnova [2017-03391] Funding Source: Vinnova; Swedish Research Council [2016-05195] Funding Source: Swedish Research CouncilThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The author would like to gratefully acknowledge the co-funding he has received for this work from the Swedish Innovation Agency Vinnova (grant number 2017-03391) and the Centre for ECO2 Vehicle Design at KTH (itself funded by Vinnova grant number 2016-05195)
Panic disorder subtypes: Further clinical differences
No full textPanic disorder (PD) is a heterogeneous phenomenon with respect to symptom profile. Most studies agree that a group of patients with prominent respiratory symptoms emerged as a distinct PD subtype. In this study we compared a range of clinical features associated with PD and agoraphobia in patients with respiratory (RS) and nonrespiratory (NRS) subtypes of PD. The participants were 124 patients with PD (79 women and 45 men), with or without agoraphobia, diagnosed by DSM-IV criteria. Following the observer-rated Panic Disorder Severity Scale assessment, subjects completed self-report measures, including the Anxiety Sensitivity Index (ASI), Panic-Agoraphobia Scale; the Beck Anxiety Inventory; and the Panic-Agoraphobic Spectrum Scale (PAS-SR). Multivariate analysis of variance (MANOVA) showed significant group differences [Pillai's trace= 0.95, F(5, 118)(=)2.48, P=.036]. Patients in RS group had higher mean total scores on the ASI (F= 5.00, df= 1, P=.027) and PAS-SR (F = 11.23, df= 1, P =. 001) than patients in NRS group. Also, patients with RS attained higher scores than patients with NRS on four domains of PAS-SR (panic-like symptoms, agoraphobia, separation sensitivity, and reassurance seeking). A descriptive discriminant analysis of the data correctly identified 69.4% of the patient group in general and 86.1% of RS group (Wilks's lambda = 0.87, df = 8, P =. 048). The significant discriminating factors of the RS and NRS groups were domains of panic-like symptoms, agoraphobia, separation sensitivity, and reassurance seeking. Our findings suggest that anxiety sensitivity and panic-agoraphobic spectrum symptoms might be particularly relevant to understanding subtypes of PD
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