957 research outputs found
Plutarch
No full textDer Text bietet eine Auseinandersetzung des Platonikers Plutarch mit dem epikureischen Lebensideal. In schroffer Antithese zu Epikurs Maxime "Lebe im Verborgenen" macht Plutarch die essentielle Bedeutung eines öffentlich verantworteten Lebens für Gesellschaft und Individuum deutlich. Die Essays widmen sich der politischen Ethik, der philosophischen Metaphorik, dem Verhältnis von Plutarch und Epikur und der Eschatologie der Schrift im Vergleich mit dem frühchristlichen 1. Clemensbrief
Anaphylaxis: case definition and guidelines for data collection, analysis, and presentation of immunization safety data
No full textJens U. Rüggeberg, Michael S. Gold, José-Maria Bayas, Michael D. Blum, Jan Bonhoeffer, Sheila Friedlander, Glacus de Souza Brito, Ulrich Heininger, Babatunde Imoukhuede, Ali Khamesipour, Michel Erlewyn-Lajeunesse, Susana Martin, Mika Mäkelä, Patricia Nell, Vitali Pool, Nick Simpson and The Brighton Collaboration Anaphylaxis Working Grouphttp://www.elsevier.com/wps/find/journaldescription.cws_home/30521/description#descriptio
Hypotonic-Hyporesponsive Episode (HHE) as an adverse event following immunization: case definition and guidelines for data collection, analysis, and presentation
No full textJan Bonhoeffer, Michael S Gold, Harald Heijbel, Patricia Vermeer, Dean Blumberg, Miles Braun, Glacus de Souza-Brito, Robert L Davis, Scott Halperin, Ulrich Heininger, Najwa Khuri-Bulos, John Menkes, Hanne Nokleb
Guidelines for collection, analysis and presentation of vaccine safety data in surveillance systems
No full textJan Bonhoeffer, Adwoa Bentsi-Enchill, Robert T. Chen, Margaret C. Fisher, Michael S. Gold, Katharina Hartman, Ulrich Heininger, Bernard Hoet, Thomas Jefferson, Najwa Khuri-Bulos, Katrin Kohl, S. Michael Marcy, David Nalin, Robert Pless, Hernan Sanabria-Rojas, Karen Sleeman, Robert Wise and The Brighton Collaboration Methods Working Grouphttp://www.elsevier.com/wps/find/journaldescription.cws_home/30521/description#descriptio
Guidelines for collection, analysis and presentation of vaccine safety data in pre- and post-licensure clinical studies
No full textJan Bonhoeffer, Adwoa Bentsi-Enchill, Robert T. Chen, Margaret C. Fisher, Michael S. Gold, Katharina Hartman, Ulrich Heininger, Bernard Hoet, Thomas Jefferson, Najwa Khuri-Bulos, Katrin S. Kohl, S. Michael Marcy, David Nalin, Robert Pless, Hernan Sanabria-Rojas, Karen Sleeman, Robert Wise and The Brighton Collaboration Methods Working Grou
A systematic review of varicella seroprevalence in European countries before universal childhood immunization : deriving incidence from seroprevalence data
No full textAbstract: Surveillance systems for varicella in Europe are highly heterogeneous or completely absent. We estimated the varicella incidence based on seroprevalence data, as these data are largely available and not biased by under-reporting or underascertainment. We conducted a systematic literature search for varicella serological data in Europe prior to introduction of universal varicella immunization. Age-specific serological data were pooled by country and serological profiles estimated using the catalytic model with piecewise constant force of infection. From the estimated profiles, we derived the annual incidence of varicella infection (/100.000) for six age groups (<5, 5-9, 10-14, 15-19, 20-39 and 40-65 years). In total, 43 studies from 16 countries were identified. By the age of 15 years, over 90% of the population has been infected by varicella in all countries except for Greece (86.6%) and Italy (85.3%). Substantial variability across countries exists in the age-specific annual incidence of varicella primary infection among the <5 years old (from 7052 to 16 122 per 100 000) and 5-9 years old (from 3292 to 11 798 per 100 000). The apparent validity and robustness of our estimates highlight the importance of serological data for the characterization of varicella epidemiology, even in the absence of sampling or assay standardization
Guidance for the collection of case report form variables to assess safety in clinical trials of vaccines in pregnancy.
No full textVaccination in pregnancy is an effective strategy to prevent serious infections in mothers and their infants. Safety of this strategy is of principal importance to all stakeholders. As the number of studies assessing safety of vaccines in pregnancy increases, the need to ensure consistent collection and reporting of critical data to allow comparisons and data pooling becomes more important. The Global Alignment of Immunization Safety Assessment in Pregnancy (GAIA) project aims to improve data collection and create a shared understanding of maternal, fetal and neonatal outcomes in order to progress the global agenda for vaccination in pregnancy. The guidance in this document has been developed to harmonize the data collected in case report forms used for safety monitoring in clinical trials of vaccination in pregnant women. Data to be collected is prioritized to allow applicability in diverse research settings, including low and middle-income countries. Standardized data will enable the research community to have a common base upon which to conduct meta-analyses, strengthening the applicability of outcomes to different settings
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