542 research outputs found
Measuring accuracy of delivery quantities from ZF Aftermarket Frydlant
No full textBakalářská práce na téma Statistické měření přesnosti dodávek výrobků od ZF Aftermarket Frýdlant je zaměřena na aplikaci statistických metod, díky kterým je možné získat potřebné informace o tom, jak si pobočka ZF Aftermarket Frýdlant stojí v roli dodavatele.V teoretické části bakalářské práce jsou uvedeny poznatky týkající se dodavatelsko-odběratelských vztahů, logistiky a statistických analýz. V praktické části je popsána práce s vnitřními systémy společnosti ZF Aftermarket Frýdlant a dále s předplacenými programy od společnosti Microsoft jako jsou MS Word, MS Excel a MS Access. Tyto programy napomáhají vytvoření databáze, která bude sloužit jako týdenní report pro Supply Chain Managera a vedení společnosti pobočky ZF Aftermarket Frýdlant.Cílem práce je vytvoření sebereflexního zhodnocení pobočky ZF Aftermarket Frýdlant v roli dodavatele.The bachelor thesis Measuring accuracy of delivery quantities from ZF Aftermarket Frydlant is focused on the application of statistical methods, which enables us to obtain the necessary information on how the ZF Aftermarket Frýdlant branch proves itself to be a supplier.The theoretical part of the bachelor thesis presents current knowledge of supplier-buyer relationships, logistics and statistical analyses. In the practical part of this work, the author works with ZF Aftermarket Frýdlant internal systems, as well as prepaid Microsoft applications such as MS Word, MS Excel and MS Access. These applications help to create the database which would be used as a weekly report for the RMG Manager and the management of the branch ZF Aftermarket Frýdlant. The main aim of this thesis is to create a self-reflective evaluation of the branch ZF Aftermarket Frýdlant as a supplier
Half-ZF beamforming scheme for downlink two-user multiple input single output-based non-orthogonal multiple access systems
No full textThe authors investigate the beamforming (BF) problem to minimise the power consumption for the downlink 2-user multiple input single output-based non-orthogonal multiple access system. Inspired from the conventional zero-forcing (ZF) scheme, they propose the Half-ZF scheme which only mitigates the interference introduced by the signal of the cell-interior user through the ZF method. Meanwhile, the interference introduced by the signal of the cell-edge user is removed through the SIC technology. We derive the closed-form expression for the BF vectors of the two users under the Half-ZF scheme. The optimal power consumption for the Half-ZF scheme is analysed and the corresponding solution of the BF factors are also obtained. Compared with the conventional ZF scheme, both the Half-ZF scheme and the existing quasi-degradation (QD) scheme can achieve lower power consumption than the ZF scheme. However, the Half-ZF scheme can achieve this advantage under more relaxed conditions. Consequently, the Half-ZF scheme consumes lower power than the QD scheme when combined with the ZF scheme in practical systems.SCI(E)ARTICLE101633-16401
Next-Generation Sequencing: Application in Liver Cancer—Past, Present and Future?
No full textHepatocellular Carcinoma (HCC) is the third most deadly malignancy worldwide characterized by phenotypic and molecular heterogeneity. In the past two decades, advances in genomic analyses have formed a comprehensive understanding of different underlying pathobiological layers resulting in hepatocarcinogenesis. More recently, improvements of sophisticated next-generation sequencing (NGS) technologies have enabled complete and cost-efficient analyses of cancer genomes at a single nucleotide resolution and advanced into valuable tools in translational medicine. Although the use of NGS in human liver cancer is still in its infancy, great promise rests in the systematic integration of different molecular analyses obtained by these methodologies, i.e., genomics, transcriptomics and epigenomics. This strategy is likely to be helpful in identifying relevant and recurrent pathophysiological hallmarks thereby elucidating our limited understanding of liver cancer. Beside tumor heterogeneity, progress in translational oncology is challenged by the amount of biological information and considerable “noise” in the data obtained from different NGS platforms. Nevertheless, the following review aims to provide an overview of the current status of next-generation approaches in liver cancer, and outline the prospects of these technologies in diagnosis, patient classification, and prediction of outcome. Further, the potential of NGS to identify novel applications for concept clinical trials and to accelerate the development of new cancer therapies will be summarized
One-hybrid system for detection of ZF–DNA interactions () Schematic of genetic selection system for interrogating ZF–DNA interactions
No full text<p><b>Copyright information:</b></p><p>Taken from "Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells"</p><p>Nucleic Acids Research 2005;33(18):5978-5990.</p><p>Published online 26 Oct 2005</p><p>PMCID:PMC1270952.</p><p>© The Author 2005. Published by Oxford University Press. All rights reserved</p> () Plasmids for one-hybrid genetic selection system. The reporter gene, either chloramphenicol acetyltransferase (CAT), or GFP is located downstream from a weak derivative promoter (P) on pDB series plasmids. A 9 bp target site for binding by the ZF is located at a specific distance from the start of transcription. On the pA series of plasmids, the gene for the ZF is fused to a fragment of the α-subunit of RNA polymerase ([]) via a sequence coding for an amino acid linker. Binding of the RpoA[1–248]–ZF fusion to the 9 bp site in the reporter plasmid recruits the other RNA polymerase subunits to stimulate transcription of the reporter gene
On the consistency of ZF with an elementary embedding from into
No full textAccording to a theorem due to Kenneth Kunen, under ZFC, there is no ordinal
and non-trivial elementary embedding . His proof relied on the Axiom of Choice (AC), and no proof from
ZF alone has been discovered.
is the assertion, introduced by W. Hugh Woodin, that
is an ordinal and there is an elementary embedding
with critical point . And
asserts that holds for some . The axiom is
one of the strongest large cardinals not known to be inconsistent with AC. It
is usually studied assuming ZFC in the full universe (in which case
must be a limit ordinal), but we assume only ZF.
We prove, assuming ZF + + " is an even ordinal",
that there is a proper class transitive inner model containing
and satisfying ZF + + "there is an elementary
embedding "; in fact we will have , where witnesses in . This result was first proved by
the author under the added assumption that exists; Gabe
Goldberg noticed that this extra assumption was unnecessary. If also
is a limit ordinal and -DC holds in , then the model will also
satisfy -DC.
We show that ZFC + " is even" + implies
exists for every , but if consistent, this theory does not
imply exists.Comment: 44 pages. Final author accepted version. For published version see
https://doi.org/10.1142/S0219061324500132. Changes this version: reorganized
order of presentation of some material (but no really new sections are
present). Slightly generalized results by dealing with relevant triples (see
Def 2.5, Theorem 4.2, etc). Various minor corrections and modification
Health Care Clinical Preceptors’ Attitudes Towards Interprofessional Education in Saudi Arabia: A Cross-Sectional Study [Corrigendum]
No full textAl Nufaiei ZF, Bukhari AA, Abalkhail NA, et al. Adv Med Educ Pract. 2024;15:343–355.
The authors have advised there is an error in the author list on page 343. The author name “Fahad Allhadian” should read “Fahad Alhadian”.
The authors apologize for this error
Hypereosinophilic syndrome with isolated Loeffler's endocarditis: Complete resolution with corticosteroids
No full textHypereosinophilic syndrome (HES) is classically defined as prolonged,
unexplained peripheral eosinophilia in a patient presenting with
evidence of end-organ damage. The heart is involved in two forms;
endomyocardial fibrosis (Davies disease) and eosinophilic endocarditis
(Loffler′s endocarditis). It was first reported in 1968 by Hard
and Anderson. Chusid and co-workers formulated a definition with strict
criteria for the diagnosis of HES as 1) peripheral blood eosinophilia
more than 1500 cells/cu mm for at least six months duration 2)signs,
symptoms of end-organ (heart, lungs, gastrointestinal tract, skin,
bone-marrow, brain) involvement with eosinophil tissue
infiltration/injury 3) exclusion of known secondary causes of
eosinophilia. We report a case of hypereosinophilic syndrome with
Loffler′s endocarditis, in the absence of endomyocardial
fibrosis. The patient presented with a eosinophilic vegetation over the
posterior leaflet of the mitral valve. There was complete resolution of
the vegetation after two months of corticosteroid therapy
Reaction chemistry of 1,4-dilithio-1,3-diene and 1-lithio-1,3-diene derivatives
No full textThe organolithium compounds, 1,4-dilithio-1,3-diene and 1-lithio-1,3-diene derivatives, show unprecedented reaction patterns with organic substrates. The 1,4-dilithio-1,3-dienes react with aldehydes or ketones via deoxygenation of the C=O moieties to afford cyclopentadiene derivatives; pyridine derivatives are obtained in excellent yields when these organolithium reagents are treated with nitriles. In addition to novel reaction patterns, the experimental results have demonstrated that both the mono- and the dilithio reagents are synthetically useful building blocks. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.Chemistry, OrganicSCI(E)0REVIEW132773-278
Hypereosinophilic syndrome with isolated Loeffler's endocarditis: Complete resolution with corticosteroids
No full textHypereosinophilic syndrome (HES) is classically defined as prolonged,
unexplained peripheral eosinophilia in a patient presenting with
evidence of end-organ damage. The heart is involved in two forms;
endomyocardial fibrosis (Davies disease) and eosinophilic endocarditis
(Loffler′s endocarditis). It was first reported in 1968 by Hard
and Anderson. Chusid and co-workers formulated a definition with strict
criteria for the diagnosis of HES as 1) peripheral blood eosinophilia
more than 1500 cells/cu mm for at least six months duration 2)signs,
symptoms of end-organ (heart, lungs, gastrointestinal tract, skin,
bone-marrow, brain) involvement with eosinophil tissue
infiltration/injury 3) exclusion of known secondary causes of
eosinophilia. We report a case of hypereosinophilic syndrome with
Loffler′s endocarditis, in the absence of endomyocardial
fibrosis. The patient presented with a eosinophilic vegetation over the
posterior leaflet of the mitral valve. There was complete resolution of
the vegetation after two months of corticosteroid therapy
On interference between two circular cylinders at supercritical Reynolds number
No full textThe results of investigation of interference between two identical parallel circular cylinders carried out in a uniform smooth flow at supercritical Reynolds number (4.5 x 10(5)), by means of pressure distribution measurement in wind-tunnel testing, are presented and discussed. The results show that the characteristics of interference are completely different with those at subcritical Reynolds number due to the difference of wake structure behind cylinders. The flow around two cylinders in tandem arrangement, which is somewhat like the case of subcritical Reynolds number, may be classified into two distinct regimes and four patterns of pressure distribution. On the other hand, two distinct regimes and three types of pressure patterns may be identified in side-by-side arrangement. The abrupt changes in pressure distributions on both cylinders were observed in the special case of two cylinders in staggered arrangement. In general, the significant effect of interference between two circular cylinders at supercritical Reynolds number is restricted to be within a rather small spacing ratio (N/d = 1.7), except for two cylinders in tandem arrangement and its vicinity.Engineering, CivilMechanicsSCI(E)EI11ARTICLE2-3175-1906
- …
