170,993 research outputs found
Medicina interna sistematica. Con CD-ROM Castagna, A: Novati, R; Tambussi, G; Uberti Foppa C Capitolo 97 - Infezioni in situazioni particolari
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Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use
No full textMultiple direct-acting antiviral (DAA)-based regimens are currently approved that provide one or more interferon-free treatment options for hepatitis C virus (HCV) genotypes (G) 1â6. The choice of a DAA regimen, duration of therapy, and use of ribavirin depends on multiple viral and host factors, including HCV genotype, the detection of resistance-associated amino acid (aa) substitutions (RASs), prior treatment experience, and presence of cirrhosis. In regard to viral factors that may guide the treatment choice, the most important is the infecting genotype because a number of DAAs are genotype-designed. The potency and the genetic barrier may also impact the choice of treatment. One important and debated possible virologic factor that may negatively influence the response to DAAs is the presence of baseline RASs. Baseline resistance testing is currently not routinely considered or recommended for initiating HCV treatment, due to the overall high response rates (sustained virological response >90%) obtained. Exceptions are patients infected by HCV G1a when initiating treatment with simeprevir and elbasvir/grazoprevir or in those with cirrhosis prior to daclatasvir/sofosbuvir treatment because of natural polymorphisms demonstrated in sites of resistance. On the basis of these observations, first-line strategies should be optimized to overcome treatment failure due to HCV resistance
La vecchiaia di Foppa
No full textIl testo ripercorre l'attività di Vicenzo Foppa (Brescia 1430 c. - 1515 c.) nel corso dell'ultimo decennio del Quattrocento e dei primi anni del nuovo secolo. Particolare attenzione è dedicata al dialogo intrapreso del pittore con le novità che scuotevano in quella stagione la pittura milanese, dalle esperienze prospettiche di Bramantino alla diffusione del linguaggio leonardesco
Un progetto, uno spazio, una prospettiva. Indagine riflettografica della Pala Bottigella di Vincenzo Foppa
No full textL'indagine riflettografica della Pala Bottigella, unitamente a quella radiografica, permette di chiarire alcuni aspetti particolarmente importanti delle modalità esecutive adottate da Foppa durante l'esecuzione della Pala Bottigella. Si ha conferma, tra l'altro, della presenza del Beato Domenico e della Beata Sibilla Biscossi fin dal primo momento della progettazione dell'opera
HLA-associated susceptibility to AIDS: HLA B35 is a major risk factor for Italian HIV-infected intravenous drug addicts
No full textThirty-one AIDS patients were typed for HLA A, B, C, and DR antigens. We confirmed that frequency of B35 is significantly higher in patients than in controls. No significant frequency differences in other HLA antigens were found. The analysis of HLA distribution in AIDS patients by risk categories suggests that B35 is a major risk factor, primarily mainly for patients belonging to the category of intravenous (IV) drug addicts
Virological and Serological Discordant Profiles in COVID-19 Pneumonia: Two Atypical Clinical Cases
No full textSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is primarily diagnosed through viral RNA positivity in nasopharyngeal swabs, and it is associated with the early detection of specific immunoglobulins to SARS-CoV-2 proteins. We describe two moderate coronavirus disease 2019 (COVID-19) patients with WHO score 4/5 at the time of hospitalization, pneumonia, and oxygen saturation <94% and with a strong discrepancy between viral RNA and antibodies to SARS-CoV-2. One patient was positive for viral RNA but completely negative for binding and neutralizing antibodies, whereas the second patient was negative for viral RNA but with high levels of both neutralizing and binding antibodies. This observation is relevant to better understand the pathogenesis of this novel infection
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