12 research outputs found
Yao yue zhong de zhi xu: lun wan Ming nan feng xiao shuo ji xi qu zhong de xing bie shu xie
No full textM.Phil.Male homoerotic sensibilities have been playing a role in human society for a long time and started to emerge as a research topic among scholars in the 70s. Over the past few decades, Chinese ancient male homoerotic sensibilities began to reveal as the research proceeds further, in which “feminization” of the penetrated male is a broadly recognized important feature among scholars.This thesis aims to discuss and analyse the phenomenon of “feminization” in scholar perspective, and find out the relationship between “male homoerotic sensibilities/erotic” and “gender”. Fictions and Chinese opera scripts from the late Ming Dynasty have been studied, focusing on “Longyang Yishi”, “Y ichun Xiangzhi”, “Bian er Chai”, “Shidiantou Panwenzi Qihe Yuanyangzhong” and “Nan Wanghou.” By analyzing the way how gender is portrayed in the writings, and integrating gender perspective of the time, this thesis will share an interpretation of the role of gender in male homoerotic sensibilities, and shed a light on power relationship in male same sex desire.男風是自古已有的社會現象，於70年代開始進入研究者的視野。數十年來，隨著學者的深入討論，中國古代男風面貌日益清晰。當中，被動角色的「女化」成為學界公認的男風特點。本文以回應及再思有關「女化」現象的學術觀點為研究開端挖掘「男風／色」與「性別」之關係。筆者整合晚明時期的男風小說及戲曲文本，選取《龍陽逸史》、《宜春香質》、《弁而釵》、《石點頭．潘文子契合鴛鴦塚》及《男王后》為主要研究對象，希望通過分析作品中的性別書寫，結合當代的性別研究理論，闡釋性別在男風中扮演的角色及梳理當中的權力關係。本文提出以「去權化」的概念代替「女化」，強調被動角色的性別身份處於不穩定狀態，不斷在「男」和「女」中游離。而面對性別失秩帶來的衝擊，不同作者的處理各異，筆者透過分析被動角色的結局和女性角色的作用，指出作者通過文學處理重塑權力秩序。葉雅詩."2020年1月".Thesis M.Phil. Chinese University of Hong Kong 2020.Includes bibliographical references (leaves 56-63).Abstracts in Chinese and English.Title from PDF title page (viewed on February 21, 2022).Ye Yashi
Rotterdam Harbour Police: the concepts of openness and closeness applied to window openings
No full textWindow openings allow communication between the interior and the exterior, but they are also elements that allow the user to control several aspects such as the light, sound, air, and privacy. Although people spend a great time inside, windows do have a strong relationship with the outdoor space and can influence a building’s openness or closeness. This relation has changed during the years with the introduction of new window opening types. (Orvell & Meikle, 2009). When referring to openness it cannot be thought about as visual transparency alone. In fact, it is related to all senses. It can be seen as the medium to regulate the functional between interior and exterior.” (Ayoub & Koba Yashi, 2001). This paper is part of the graduation studio Revitalising 20th century Heritage, aims to research theprocess of assessment of the role the window openings present in the three buildings of the Rotterdam Harbour Police station play in defining the building’s openness or closeness. This research is positioned in larger research on how window openings help define a building’s openness or closeness towards the surroundings and creating a helpful ‘design options palette’ when having to intervene in a building’s openness or closeness. The research concludes that most of the windows present in the oldest building present a high openness, as well as in the 1994 building. On the contrary, the 1940 building presents window typologies with a high closeness. However, this research needs to be further developed in relation to other elements.Adapting 20C HeritageArchitecture, Urbanism and Building Sciences | Heritage & Architectur
A Case of Secondary Syphilis Mimicking a Penile Cancer with Lymph Node Metastases
Get PDFA 42-year-oldman visited our hospital because of gradually worsening penile swelling over 3 weeks. A hard mass on the glans was palpated; however, we were unable to observe it due to severe phimosis. Magnetic resonance imaging of the pelvis revealed enlargement of glans and swelling of bilateral inguinal lymph nodes as both showed a low signal intensity on T2-weightedimaging, a high signal intensity on diffusion-weighted imaging, and a low signal intensity on the apparent diffusion coefficient map. Fluorine- 18-deoxyglucose (FDG) positron emission tomography showed FDG uptake at the external iliac, common iliac, obturator, and cervical lymph nodes besides the glans and inguinal lymph nodes. Although his serum squamous cell carcinoma antigen level was within the normal range, his soluble interleukin-2 receptor concentration was elevated to 2, 290 U/ml. Therefore, we diagnosed these lesions as penile cancer with multiple lymph node metastases, with a possible differential diagnosis of malignant lymphoma. We planned a penile needle biopsy; however, the rapid plasma reagin test and treponema pallidum hemagglutination test, which were performed during the preoperative examination, were positive and led to a diagnosis of secondary syphilis. The patient was treated with oral amoxicillin at 1, 500 mg/day for 8 weeks. The penile and lymph node swelling subsided after starting medication
BiliBili, Douyin and Xiaohongshu as health information platforms for stroke: evaluating information quality and content
No full textAbstract Stroke remains a significant global health concern. Despite numerous stroke-related videos on social media, research evaluating their information quality across platforms remains limited. This study compares information quality and content of stroke-related videos on BiliBili, Douyin and Xiaohongshu. This study analyzed 227 stroke-related videos across three platforms (58 from BiliBili, 88 from Douyin and 81 from Xiaohongshu). Information quality was assessed using adapted HONCode and PEMAT-A/V standards. Content analysis examined stroke aspects (definition, symptoms, etiology, assessment, treatment, outcome, complications, risk factors and prevention). Statistical analyses included Mann–Whitney U, Kruskal–Wallis and Spearman correlation analysis. Overall, videos showed moderate information quality (72.7% achieving medium HONCode levels). Compliance rates were 4.0% for Principle 4 (source reference) and 2.2% for Principle 5 (evidence for claims). Videos showed higher understandability (median 0.73; IQR 0.2) but suboptimal actionability (median 0.67; IQR 1.0). Content completeness was low (median 2.00, IQR 3.0), with treatment (63.0%) and symptoms (55.1%) mentioned most frequently and assessment (15.4%) and complications (15.0%) less frequently. Spearman’s correlation analysis indicated that there were mostly no correlations between video information quality and user engagement (Likes, Collections, Comments, Shares) on the three platforms. Specifically, among the three platforms, Douyin had significantly higher information quality (P < 0.001), while Xiaohongshu showed lower understandability (P = 0.032) and content completeness (P < 0.001). Stroke videos’ information quality on BiliBili, Douyin and Xiaohongshu was generally moderate, but commonly lacked evidence support, actionability and content completeness. Among these platforms, Douyin demonstrated relatively better performance, while Xiaohongshu showed poorer understandability and completeness. This study recommends that video publishers focus on enhancing evidence support and actionability, particularly regarding stroke assessment and complications, to help the public access more accurate and complete stroke information. For BiliBili and Xiaohongshu, increasing medical professional participation is recommended to improve information quality. Xiaohongshu needs to improve content understandability by using simpler and clearer language to explain stroke-related knowledge
Efficacy, safety, and immunogenicity of recombinant insulin aspart (BioGenomics Limited) and NovoRapid® (Novo Nordisk) in adults with type 2 diabetes mellitus: a randomized, open-label, multicenter, phase-3 study
No full textBackground and purpose:
To compare the efficacy, safety, and immunogenicity of recombinant insulin aspart 100 U/mL manufactured by BioGenomics Limited (BGL-ASP) with innovator NovoRapid® in type 2 diabetes mellitus patients (T2 DM).
Experimental approach:
This was a multicenter, open-label, randomized, parallel-group study in T2 DM patients, on premix human insulin therapy ± oral anti-diabetics. Besides self-monitored plasma glucose, fasting and post-prandial plasma glucose (FPG and PPG) were tested at baseline, week 12, and week 24. Anti-insulin aspart antibodies measured immunogenicity at 12 and 24 weeks.
Findings/Results:
160 patients out of 320 patients randomly received BGL-ASP and the remaining patients received NovoRapid®. The changes in glycated hemoglobin (HbA1c) from baseline to weeks 12 and 24 for the BGL-ASP group were -0.8 ± 0.83 and -0.8 ± 0.81, respectively, while for the NovoRapid®group was -0.8 ± 1.01 and -0.9 ± 0.89, respectively. Changes in FPG and PPG were comparable between the treatment groups after 12 weeks and 24 weeks. The incidence of detectable antibodies at baseline, weeks 12, and 24 were comparable between treatment groups. Eighteen (11.3%) patients in the BGL-ASP group and 23 (14.4%) in the NovoRapid®group reported adverse events.
Conclusion and implications:
BGL-ASP and NovoRapid®were comparable and equally effective in lowering HbA1c, FPG, and PPG levels, with similar immunogenicity and safety profiles
Morphometric and immunohistochemical studies on mechanosensory innervation of the muscle spindle
Get PDFThe purpose of this thesis is to study aspects of the function of the primary sensory endings of muscle spindles using morphometric and immunohistochemical techniques. For morphometry the right tenuissimus muscles of three adult cats, whose right hind limbs were fixed with the hip and knee flexed at various acute angles, have been compareed with the corresponding muscles from the fully extended left hind limbs of the same animals. The aim of this project is a better understanding of morphometric changes in the muscle spindle including intrafusal fibre diameter, sarcomere length, and (in particular) changes in the primary nerve endings in response to passive stretch. Immunohistochemical studies of the calcium-binding protein, calretinin, and immunogold labelling for glutamate were also carried out on the primary nerve endings as detailed below. All the work reported in this thesis was carried out in the School of Biological and Biomedical Sciences, at the University of Durham. This thesis is divided into five chapters. Chapter one is an introduction to the structure and innervation of the muscle spindle andtendon organ, discussing briefly the presence of calretinin and glutamate in muscle spindle nerve endings. This provides general introduction and background to the work. Chapter two describes the deformation of the nerve endings in the muscle spindle when the cat tenuissimus muscle is subjected to different degrees of flexion of the hip and knee on the experimental side, the control side being extended so that the angles between the hip and the knee were approximately equal in the each case. For rapid and optimum fixation, both sides were perfused with fixative solution. The results show morphometric changes in the experimental muscles compared with the controls in tem1s of diameter, sarcomere length, and sensory nerve terminal deformation. Muscle fibres in the experimental (flexed) side have a greater diameter, and shorter sarcomeres, with nerve endings more indented into the intrafusal fibres, compared with those on the extended, control side. Nuclei of the equatorial region in both the experimental and control muscles differed in arrangements of nuclei and their outline. Chapter three discusses the calcium-binding proteins, with the emphasis on calretinin and its distribution in the nerve endings of rat muscle spindles and tendon organs as shown by histochemical examination of rat soleus muscle. The calretinin distribution was evident in the primary endings of both bag 1 and bag2 fibres and also in the primary endings of the chain fibres, although no secondary endings or tendon organs were observed.Chapter four describes quantitative immunological study carried out on the muscle spindle of the cat tenuissimus muscle to assess the comparative level of glutamate -like immunoreactivity in the equatorial region of the primary nerve endings, and their associated intrafusal fibres, were all found to show less glutamate -LI compared with the secondary nerve endings and their associated intrafusal fibre, but not the intrafusal fibrenuclei. In chapter five the results are summarised, and possible further studies outlined
Influenza virus activation of the interferon system
Get PDFThis study was supported by the Wellcome Trust (grant number 087751/A/08/Z) and the Medical Research Council (grant number G0700848).The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process.Peer reviewe
陰茎癌リンパ節転移が疑われた第2期梅毒の1例
No full textA 42-year-oldman visited our hospital because of gradually worsening penile swelling over 3 weeks. A hard mass on the glans was palpated; however, we were unable to observe it due to severe phimosis. Magnetic resonance imaging of the pelvis revealed enlargement of glans and swelling of bilateral inguinal lymph nodes as both showed a low signal intensity on T2-weightedimaging, a high signal intensity on diffusion-weighted imaging, and a low signal intensity on the apparent diffusion coefficient map. Fluorine- 18-deoxyglucose (FDG) positron emission tomography showed FDG uptake at the external iliac, common iliac, obturator, and cervical lymph nodes besides the glans and inguinal lymph nodes. Although his serum squamous cell carcinoma antigen level was within the normal range, his soluble interleukin-2 receptor concentration was elevated to 2, 290 U/ml. Therefore, we diagnosed these lesions as penile cancer with multiple lymph node metastases, with a possible differential diagnosis of malignant lymphoma. We planned a penile needle biopsy; however, the rapid plasma reagin test and treponema pallidum hemagglutination test, which were performed during the preoperative examination, were positive and led to a diagnosis of secondary syphilis. The patient was treated with oral amoxicillin at 1, 500 mg/day for 8 weeks. The penile and lymph node swelling subsided after starting medication
Оперативное лечение стриктур нижней трети мочеточника после лучевой терапии органов малого таза
Get PDFPostradiation obstructive changes of distal parts of the ureter most commonly occur after radiation therapy for cervical cancer, endometrial cancer, bladder cancer. Pathogenesis of postradiation lesions of the ureteral wall are explained by destructive effects of radiation on the basal membranes of the capillary cell, causing an occlusion, thrombosis, and neovascularization, which in turn leads to proliferation of fibroblasts and stromal fibrosis. Possible complications include hematuria, urinary tract infections, vesicoureteral reflux, stent migration, stent encrustation. By the way, presence of the stent is often associated with pain and discomfort in patients. Aim of this work is to improve the results of treatment of strictures of the lower ureter following radiotherapy, by evaluating effectiveness of extravesical uretherocystoanastomosis and Boari procedure. Введение. Расширение показаний к проведению лучевой терапии при онкологических заболеваниях органов малого таза и использование больших доз радиационного излучения с целью достижения наибольшего эффекта нередко приводят к обструктивным осложнениям дистальных отделов мочеточников. Выраженные трофические изменения, обуславливающие большой процент неудовлетворительных результатов реконструктивных операций, делают актуальным проблему выбора оптимального метода лечения постлучевых стриктур мочеточников.Целью настоящей работы явилось улучшение результатов лечения постлучевых стриктур нижней трети мочеточника посредством оценки эффективности экстравезикального уретероцистоанастомоза и операции Боари.Материалы и методы. Материалом для данной работы послужили результаты лечения 192 пациенток со стриктурами и облитерациями нижней трети мочеточника за период с 2007 по 2015 гг. Все пациенты были разделены на 3 группы: I группа (n=49) - пациенты с протяженностью дефекта мочеточника менее 4 см, которым был выполнен экстравезикальный уретероцистоанастомоз (операция Барри); II (n=45) и III (n=98) группы составили пациенты с протяженностью дефекта мочеточника 4-15 см, которым была выполнена операция Боари, с использованием антирефлюксной техники и без антирефлюксной защиты, соответственно. Медиана периода наблюдения составила 38,2 мес. (12-96 мес.). Оценивали функцию почек (по данным изотопной ренографии), число эпизодов обострения хронического пиелонефрита в течение года, количество рецидивов стриктур или облитераций мочеточников, количество случаев возникновения клинически-значимого ПМР.Результаты. Полное восстановление проходимости мочеточника было зафиксировано у 47 (96%), 43 (95,5%) и 98 (100%) в I, II и III группах, соответственно. Всем пациентам с неудовлетворительным результатом в последующем были выполнены повторные операции с положительным эффектом. Медианы дефицита функции почки до и после операции в I, II и III группах составили 34% (22,00:58,5) и 32% (15,75:39,00), 44% (28,00:61,75) и 38% (16,00:42,00), 46% (31,00:65,00) и 45% (32,00:61,00), соответственно. Преимущественным осложнением в послеоперационном периоде являлось обострение хронического пиелонефрита, наблюдавшееся в 14,6% случаев, и в большинстве случаев носящие однократный характер и купировавшиеся консервативно. У 5 пациенток после проведенного лечения отмечено возникновение клинически-значимого ПМР, сопровождающегося частыми обострениями хронического пиелонефрита (1-2 раза в год) и увеличением дефицита функции почки на 10% от исходных данных.Выводы. Полученные результаты позволили нам заключить, что экстравезикальный уретероцистоанастомоз является оптимальным методом лечения постлучевых стриктур и облитераций мочеточника при протяженности дефекта до 4 см. При более протяженных дефектах целесообразно применение операции Боари. Антирефлюксная техника при выполнении данной операции не оказывает существенного влияния на результат лечения
