530 research outputs found
Business Model in Air Transport: Evolution of Innovation Concept
No full textWith the advent of the knowledge society, new opportunities,
business models and concepts have emerged in most industrial sectors and in
particular in the transport sector. The European air travel market, dominated
by airlines, influenced to varying degrees from their countries of origin, has
been, since the early nineties, completely revolutionized by the entrance in
the competitive arena of several small companies, which, in accordance with
the principles of „disruptive innovation‟, have completely changed the field
of passenger transport. To understand how this was possible, it is necessary
to investigate, just with the help of these new tools of Strategic Management
as the business models, about the way in which these airlines are able to
generate their business and create value.
This work aims to analyse the close relationship between innovation of
product / service and corporate business model in order to understand the
dynamics of the relationship. Various contributions from literature showed
how the concept of innovation within the company has evolved over the
years and what were the approaches used to study it. This analysis begins
with the study of the contributions of Schumpeter, the first economist to
write about innovation and author of the dynamic development model and
creator of the first distinction between innovation and invention. His theories
have made a major contribution in this area, but none the less were also
constructively criticized by other economists such as Freeman, who
introduced the concept of incremental innovation and analysed the factors
triggering innovation. Albernathy and Clark then added another fundamental
element of analysis: the competitive environment. They studied the influence
of innovation on those factors that are considered essential to achieve a
competitive advantage. The same Albernathy, with Utterback, then studied
the dynamics of innovations over time. Each of the cited authors analysed
the phenomenon of innovation in a different light and all of their
contributions allows for a broad and comprehensive concept. The picture is completed by adding the recent contributions of Christensen, who has taken
up and deepened the concepts of "sustaining innovation" and " disruptive
innovation" and, especially, began to highlight how essential it is that
innovation is supported by a suitable business model. In this regard, he has
shown that even the same business model can be object of innovation and
that this type of innovation is one of the main drivers of the creation of
competitive advantage
[Prognostic factors in bronchopulmonary neoplasms].
No full textThe paper aims to illustrate the current state of knowledge regarding the prognostic factors of lung cancer. The disappointing results obtained using therapeutic modes (an overall 5-year survival rate of 15%), together with the considerable variability of the natural history of lung cancer, should be attributed to a group of prognostic factors, of varying importance, which can be subdivided into three categories: those concerning the characteristics of cancer, those inherent to the patient's conditions and those related to the type of operation. The paper underlines that histotype, TNM staging, the assessment of the nuclear degree and ploidy class play a correct and real prognostic role, and that only surgical treatment, if indicated, can offer a real life expectancy (40% 5-year survival rate in operated patients)
Overcoming resistance to osimertinib in non–small cell lung cancer: Hopes, doubts, and in-between
No full text[Dysphagia associated with aorto-cardiac compression on the distal esophagus: a rare event but not exceptional in the elderly].
No full textAmong the pathologies responsible for dysphagia in the elderly, the aortic compression on the distal oesophagus awakens a certain clinical interest. Cipho-lordosis, which is often present in aged females, worsens the effects of this compression causing other kinkings on the oesophagus already hypokinetic because of the age (presbyoesophagus). This illness often shows scare symptoms, but sometimes requires a pneumatic dilation to allow normal food assumption of the patient. The authors report on their experience of two cases, clearly documented from the diagnostic point of view; the first one was given medical treatment, the second one was treated with a pneumatic dilatation of the cardias
[Reappearance of esophageal peristalsis after treatment of achalasia. Reality or artifact?].
No full textThe authors discuss the question of the reappearance of esophageal peristalsis following surgical or dilating treatment in patients with a diagnosis of cardiospasm. On the basis of their experience and an extensive review of the literature, the authors affirm that the reappearance of motor activity should not be attributed to a condition of pure achalasia but rather to an intermediate motor disorder with pseudo-achalasic characteristics which are difficult to discriminate
[Special problems in the surgical treatment of megaesophageal cardial achalasia. A clinical case].
No full textThe paper report the case of a patient brought to the Authors' attention suffering from megaesophageal cardial achalasia who had already undergone gastroduodenal resection according to BII. It was considered worthwhile to report this case due to the problems which arose concerning the choice of a thoracic rather than abdominal route owing to the impossibility of associating cardiomyotomy with anti-reflux plastica surgery because of the reduced dimensions of the stomach
[Current aspects and controversies in reconstructive surgery after esophagectomy: personal experience].
No full textThe authors report their series of 184 esophagectomies performed both for benign (44) and malignant (140) diseases. On the basis of their experience and supported by Literature data, it is believed restoration of digestive continuity offers two main points of discussion: choice of the intestinal tract for the interposition and type of anastomosis to perform. The nature of the lesion and its level seems to play the most important role in the choice
Napoli e la cooperazione. Un’indagine sul campo
No full textCooperazione nel
Napoletano. Il luogo
comune direbbe che
si tratta di una
contraddizione: per le
condizioni particolari,
spesso degradate, del
tessuto sociale; e per
la scarsità di tradizioni
c o o p e r a t i v e . Q u e s t a
ricerca, pur non
smentendo arretratezza
e difficoltà, ci dà però
un quadro più articolato,
in cui l’esperienza
cooperativa è anche
uno strumento per
sostenere la battaglia
che una grande
metropoli del
Mezzogiorno e il suo
hinterland combattono
per irrobustire il proprio
tessuto economico
e civile e per inserirsi
a pieno titolo in una
prospettiva generale
di svilupp
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