588 research outputs found
National statistics about resection of the primary tumor in asymptomatic patients with Stage IV colorectal cancer and unresectable metastases. Need for improvement in data collection. A systematic review with meta-analysis
No full textBackground: Patients with asymptomatic Stage IV colorectal cancer represent a significant heterogeneous group. National statistics represent an effective method to follow in real time the clinical outcomes of patients, and they may represent an important tool to analyze and to compare different therapeutic approaches. The aim of our study was to analyze the reviews of national data and single institutions reports, which compared the clinical outcomes of patients with asymptomatic Stage IV colorectal cancer and un-resectable metastases who had resection of the primary tumor with those who did not have resection. We gave special attention to the number of missing established relevant variables, to determine the appropriateness of the results of the published studies. Material: We performed a systematic review of papers comparing patients who had and who had not primary tumor resection. Screened reports included the time of publication from June 2012 to June 2018; 2556 papers were identified and 27 were included into the review. The primary outcome was observed survival. We analyzed the number of major missing variables in National Data Bases and Single Institution Reports, to assess the overall validity of the conclusions of the analyzed reports. Results: In the majority of the reports and in the meta-analysis of studies with propensity score matching, resection of the primary tumor was correlated to improved survival and to the possibility for a better response to postoperative chemotherapy. Conclusions: The high number of missing significant variables, and a clear clinical selection in single center reports make any analysis error-prone. National statistics might represent a valid method to follow in real time the clinical outcomes of these patients, comparing different therapeutic approaches. There is the need for improvement in national data collection, to make descriptive national statistics the ground for future progress in treatment. (PROSPERO) CRD 42018089691
Su un caso di cisti di echinococco a estrinsecazione endobronchiale
No full textGli autori descrivono un caso di echinococco ad estrinsecazione endobronchiale che è stato risolto mediante l'utilizzazione del broncoscopio rigido, sia dal punto di vista diagnostico che terapeutico
Theoretical analysis of the addition of hydroxylamine to uracil and 5-fluorouracil as a model for the Thymidylate synthase reaction
No full textIn the present paper we report a quantum chemical (PM3) investigation of reagents, transition structures, intermediates and final products of the nucleophilic addition of hydroxylamine to uracil (U) and 5-fluorouracil (FU). This reaction serves as a model for the more complex enzymatic methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) and 5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP) by thymidylate synthase. From the analysis of the frontier orbitals of the isolated and complexed species, as well as from the calculation of activation barriers, we propose that nucleophilic attack usually proceeds after formation of an initial complex between U (or FU) and one neutral and one protonated molecule of hydroxylamine. Our results give some insight into the mechanism of these reactions and account for the higher rate of addition of hydroxylamine to FU, compared to U. The main connection between the chemical simulation and the biological scheme is that in both reactions hydrogen bonding residues are found to be necessary to assist catalysis
Laboratory of reference for trypanosomatidic infections -In-Vitro-and-In-Vivo-Screenings-of-New-Antiparasitic-Compounds-State-of-the-art-and-New-Developments-COST B22
No full text2008 | Action Number: B22
In Vitro and In Vivo Screenings of New Antiparasitic Compounds: State-of-the-art and New Developments
Pages: 92
Author(s): Reto Brun, Donatella Taramelli
Publisher(s): Swiss Tropical Institute
Joint meeting of COST B22 WG3 Drug Evaluation, WG4 Preclinical Research and EU-IP Antimal
European COST B22 Lab for antiparasitic drug screening (http://www.icp.ucl.ac.be/cost/costB22/ screening_survey.pdf )-2008-2012.
No full textEuropean COST B22 Lab for antiparasitic drug screening (http://www.icp.ucl.ac.be/cost/costB22/ screening_survey.pdf ). My lab is part of the new COST action on “Drug development in parasitic diseases” CM0801 (http://www.costcm0801.org/CM0801/Welcome.html ) 2008-2012. The initiative is reported in the following text: 2008 | Action Number: B22
In Vitro and In Vivo Screenings of New Antiparasitic Compounds: State-of-the-art and New Developments
Pages: 92
Author(s): Reto Brun, Donatella Taramelli
Publisher(s): Swiss Tropical Institute
Joint meeting of COST B22 WG3 Drug Evaluation, WG4 Preclinical Research and EU-IP Antimal
Commercio elettronico
No full textLa voce "Commercio elettronico", dell'Enc. dir., analizza in chiave sistematica la disciplina giuridica del Commercio elettronico, sia in riferimento al diritto interno, sia in riferimento al diritto europeo, ponendo altresì in evidenza ed affrontando gli aspetti problematici che la materia presenta
[Surgery associated with intraoperative hyperthermia-chemotherapy in the treatment of malignant tumors of the digestive system with peritoneal carcinosis].
No full textSurgery and intraperitoneal hyperthermochemotherapy in the treatment of malignant gastrointestinal tumors.
In the last two years the Authors have treated 4 patients affected with malignant tumors of large bowel with very poor prognosis. In every cases they found large spreading to peritoneal cavity. These patients underwent to intraperitoneal iperthermochemotherapy using a special device conceived by Authors. This treatment produced promising results as related to life quality in these cases.Chirurgia associata ad ipertermochemioterapia intraoperatoria nel trattamento dei tumori maligni dell’apparato digerente con carcinosi peritoneali.Nell arco di due anni sono stati sottoposti ad ipertermochemioterapia intraperitoneale 3 pazienti affetti da neoplasia maligna del grasso intestino ed 1 da neoplasia maligna gastrica con disseminazioni peritoneali multiple. I pazienti inclusi nello studio sono stati sottoposti a trattamento ipertermico e chemioterapico della cavita peritoneale mediante l'uso di un dispositive meccanico da noi messo a punto.
Il trattamento ha prodotto prometcenti risultati per quanto riguarda la qualita di vita det pazienti giunti a questo stadio di malatta
Has desmoplastic response extent protective action against tumor aggressiveness in gastric carcinoma?
No full textBackground & aims: The role of desmoplasia in colorectal carcinoma progression is unclear and the presence of collagen stroma may represent a barrier against cancer diffusion and vascular invasion or a stroma to build up and support the tumor. The aim of this study was to evaluate the effect of desmoplastic response on long-term survival of patients who underwent radical resection for colorectal carcinoma. Methods: The study included 429 patients who underwent radical colorectal resection for cancer with a median follow-up period of 72.8 months. Results: At univariate analysis significant associations were observed between desmoplasia and histologic type, parietal infiltration, growth pattern, and staging. No associations were found between desmoplasia and the other clinical and histologic parameters. The multivariate analysis stratified for tumor stage revealed that the factor showing the most favorable influence on time to death was desmoplasia. The presence of desmoplasia was likely to decrease the failure rate to a third of the rate experienced by patients without desmoplasia. Parietal infiltration was associated with an increased risk for a shortened time to death. Conclusions: Our results favor the view that desmoplasia is a protective factor for survival in patients with colorectal carcinoma. This finding is consistent with the hypothesis that desmoplasia may prevent cancer invasiveness by building a barrier against tumor diffusion
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