833 research outputs found
Dawson\u27s Creek: A Critical Understanding
No full textThis book provides a textual analysis of the WB\u27s (Warner Brothers Television) hit teen drama that ran from 1998 to 2003. Author Lori Bindig analyzes episodes of Dawson\u27s Creek as a set of media texts that blur the boundaries between hegemonic and counter-hegemonic content. Exploring the ideology encoded within Dawson\u27s Creek from a feminist cultural studies perspective, Bindig examines gender, race, class, sexuality, and consumerism as it is presented in the show. The depiction of each of these five ideological concepts is discussed beyond the framework of the series and put into a larger social context, allowing a discussion of the potential ramifications of the television program. This book suggests that although Dawson\u27s Creek includes counter-hegemonic story lines, ultimately the political-economic realities of the current media system undercuts the oppositional content and frames the program as hegemonic. Nevertheless, Dawson\u27s Creek is a valuable tool in navigating the ongoing struggle against social inequality, illustrating how far society has come and how far it has yet to go
ChemInform Abstract: Liquid‐Liquid and Solid‐Liquid Phase‐Transfer Glycosylation of Pyrrolo(2,3‐d)pyrimidines: Stereospecific Synthesis of 2‐Deoxy‐β‐D‐ribofuranosides Related to 2′‐Deoxy‐7‐carbaguanosine.
No full textIceCube-Gen2: A Vision for the Future of Neutrino Astronomy in Antarctica
No full text20 pages, 12 figures. Address correspondence to: E. Blaufuss, F. Halzen, C. Kopper (Changed to add one missing author, no other changes from initial version.)20 pages, 12 figures. Address correspondence to: E. Blaufuss, F. Halzen, C. Kopper (Changed to add one missing author, no other changes from initial version.)20 pages, 12 figures. Address correspondence to: E. Blaufuss, F. Halzen, C. Kopper (Changed to add one missing author, no other changes from initial version.)The recent observation by the IceCube neutrino observatory of an astrophysical flux of neutrinos represents the "first light" in the nascent field of neutrino astronomy. The observed diffuse neutrino flux seems to suggest a much larger level of hadronic activity in the non-thermal universe than previously thought and suggests a rich discovery potential for a larger neutrino observatory. This document presents a vision for an substantial expansion of the current IceCube detector, IceCube-Gen2, including the aim of instrumenting a volume of clear glacial ice at the South Pole to deliver substantial increases in the astrophysical neutrino sample for all flavors. A detector of this size would have a rich physics program with the goal to resolve the sources of these astrophysical neutrinos, discover GZK neutrinos, and be a leading observatory in future multi-messenger astronomy programs
Fiber-optical and microscopic detection of malignant tissue by use of infrared spectrometry
No full textSeveral investigations were performed in order to develop an in vivo endoscopic method to differentiate between malignant and healthy tissue working on the assumption that each diseased state of biological tissue has its own characteristic infrared (IR) spectral pattern. The technical design of the laboratory setup is presented here together with the experimental details and the results. Two regions (1245-1195) and (1045-995) cm-1 within the fingerprint (<1500 cm-1) region were selected for analysis. Lead salt diode lasers were used as excitation sources and IR radiation was transmitted via silver halide wave guides to the tissue to be investigated. The IR radiation is returned to a mercury-cadmium-telluride detector by another IR cable. The measurements were carried out in attenuated total reflectance and diffuse reflection/remission. Human colon carcinoma tissue, under humid conditions, was used as a target for experiments to simulate in vivo conditions. Specimens were mapped using a stepper, motor powered, x/y/z-translation stage with a spatial resolution of 1 μm. The results were compared with similar measurements from a Fourier transform IR (FTIR) interferometer/FTIR microscope setup in the wave number region of 4000-900 cm-1. © 2002 Society of Photo-Optical Instrumentation Engineers
Identification of lysing bacteriophages in natural populations of Ixodes ricinus
No full textV rámci této práce jsem popsal základní problematiku bakteriofágů, jejich historii, současnost, využití a potenciál do budoucnosti. Dále jsem popsal bakterie Anaplasma phagocytophilum a Borrelia burgdorferi ve spojení s problematikou parasitismu Ixodes ricinus. Vymyslel jsem několik metodik jak na PCR mutagenezi, tak enzymatickou mutagenezi bakteriofágů, v rámci nichž popisuji modifikaci sekvencí odpovědných za kódování vazebných proteinů u fágů napadajících Escherichia coli, tak aby byly schopné kódovat vazebné proteiny na OspA u Borrelia burgdorferi. Tyto metodiky jsou analogicky použitelné i u dalších bakterií s výskytem v populaci Ixodes ricinus i mimo ni. Mimo již zmíněných metodik jsem srovnal fágovou terapii a léčbu antibiotiky. Dále jsem popsal problematiku vztahu imunitního systému pacientů a fágů použitých ve fágové terapii, problematiku laické veřejnosti. Na závěr jsem shrnul potenciální využití fágové terapie a zmínil možné směry, kterými by se výzkum bakteriofágů mohl v budoucnu ubírat.ObhájenoIn this work I described the basic issues of bacteriophages, their history, recent state, thein use and potential for the future. I also described the bacteria Anaplasma phagocytophilum and Borrelia burgdorferi in connection with the parasitism of Ixodes ricinus. I have invented several methodologies for both PCR mutagenesis and enzymatic mutagenesis of bacteriophages. In these methodologies I describe the modification of sequences responsible for coding binding proteins in phages attacking Escherichia coli, so as to be able to encode bindig proteins for OspA proteins which are specific for Borrelia burgdorferi. These methodologies are equally applicable to other bacteria found in and outside the Ixodes ricinus population. In addition to the aforementioned methodologies, I compared phage therapy and antibiotic treatment. Furthermore, I described the issue of the relationship between the immune system of patients and phages used in phage therapy and the issue of the laic public. In conclusion I described the potential use of phage therapy, and mentioned possible directions that bacteriophage research might take in the future
Measurement of Optical Pulsation and Transmission Spectra as Reference for a Monte Carlo Simulation of the Finger Tip
No full textSilver based nanomaterials - fluorescence enhancement in silver doped silica based nanobiomaterials
No full textThe sol-gel derived silica spheres with surfaces modified by silver nanoparticles were used to enhance the emission efficiency of PDTphotosensitizer Photolon. Two various materials with different Ag concentrations were prepared by exploiting the Tollen's method. The silica nanoparticles were prepared by modified Stöber synthesis. The diameter of obtained silica spheres was ca. 100nm. These silica spheres we used as a carrier for noble nanoparticles, since they can be easily doped by various substances that can change their physical and chemical properties. The colloidal water solutions of Ag-doped SiO2 particles have been prepared. It was demonstrated that the fluorescence intensity of Photolon is influenced by silver nanoparticles concentration, however it is not proportional to the silver concentration. The fluorescence intensity of Photolon with silver doped silica nanoparticles is much higher then fluorescence intensity of Photolon in water solution. This result is very promising and may be used to enhance the photodynamic effect
Investigations on photolon-and porphyrin-doped sol-gel fiberoptic coatings for laser-assisted applications in medicine
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