117,633 research outputs found
L’Archivio della Fabbrica di San Pietro in Vaticano come fonte per la storia di Roma
No full textQuesto volume raccoglie i frutti di alcuni dei più recenti studi condotti sui
documenti dell’Archivio Storico della Fabbrica di San Pietro da un gruppo di
ricercatori provenienti da ambiti scientifici e accademici diversi; si tratta di studi
selezionati con il triplice obiettivo di evidenziare il carattere fortemente
interdisciplinare delle ricerche, di diffonderne i risultati e di mettere in luce
l’influenza che le attività della Fabbrica hanno esercitato nel corso dei secoli sullo
sviluppo culturale, tecnico-edilizio, economico e sociale della città di Roma.
I dieci saggi che compongono l’opera, infatti, tratteggiano in modo inequivocabile
un legame indissolubile con la città eterna: la vicenda plurisecolare della Fabbrica
di San Pietro si radica profondamente in quella di Roma, che a sua volta trova
nelle carte dell’Archivio della Fabbrica una fonte di conoscenza storica unica,
preziosa, insostituibile
The use of temozolomide for the treatment of malignant tumors: clinical evidence and molecular mechanisms of action
No full textTemozolomide (TMZ) is a monofunctional methylating agent which is spontaneously activated in aqueous solution into the dacarbazine metabolite 5-(3-methyl-1-triazeno)imidazole-4-carboxamide. This drug has been approved for the treatment of metastatic melanoma and glioblastoma multiforme, the latter in combination with radiotherapy. Furthermore, clinical trials have been performed to assess the activity of TMZ, alone or in combination, on brain metastatic solid tumors and leukaemias. This review will report clinical evidence on the use of TMZ for the treatment of different types of cancer; it also considers current knowledge on TMZ's molecular mechanisms of action of and discusses relevant patents relating to the same drug
Processi di Recollection e Familiarità in compiti di riconoscimento in pazienti con amnesia ippocampale
No full textRecollection and familiarity in hippocampal amnesia
No full textCurrently, there is a general agreement that two distinct cognitive operations, recollection and familiarity, contribute to performance on recognition memory tests. However, there is a controversy about whether recollection and familiarity reflect different memory processes, mediated by distinct neural substrates (dual-process models), or whether they are the expression of memory traces of different strength in the context of a unitary declarative memory system (unitary-strength models). Critical in this debate is the status of recognition memory in hippocampal amnesia and, in particular, whether the various structures in the medial temporal lobe (MTL) contribute differentially to the recollection and familiarity components of recognition. The present study aimed to explore the relative contribution of recollection and familiarity to recognition of words that had been previously read or that had been previously generated in a group of severely amnesic patients with cerebral damage restricted to the hippocampus. A convergent pattern of results emerged when we used a subjective-based (remember/know; R/K) and an objective-based (process dissociation procedure; PDP) methods to estimate the contribution of recollection and familiarity to recognition performance. In both PDP and R/K procedures, healthy controls disclosed significantly higher recollection estimates for words that had been anagrammed than for words that had been read. Amnesic patients'' recollection scores were not different for words that had been generated or that had been read, and the recollection estimate for words that had been generated was significantly reduced as compared to the group of healthy controls. For familiarity, both healthy controls and amnesic patients recognized as familiar more words that had been generated than words that had been read, and there was no difference between the two groups. These data support the hypothesis of a specific role of the hippocampus in recollection processes and suggest that other components of the MTL (e.g., perirhinal cortex) may be more involved in the process of familiarity
MANUFACTURE AND CHARACTERIZATION OF CONTINUOUS SIC FIBER REINFORCED ALUMINUM COMPOSITES BY LOW-PRESSURE PLASMA SPRAYING
No full textTHE FEASIBILITY OF THE LOW PRESSURE PLASMA SPRAYING (LPPS) PROCESS FOR PRODUCING CONTINUOUS FIBER REINFORCED METAL MATRIX COMPOSITES IS EVALUATED ON A LABORATORY SCALE. THE REINFORCEMENT USED WAS 140 MICRON DIAMETER SIC/C LONG FIBERS, WHILE ALUMINIUM WAS DEPOSITED AS MATRIX MATERIAL. RESULTS OF PRELIMINARY CHARACTERIZATION TESTS ARE PRESENTED, IN ORDER TO EVALUATE THE OVERALL QUALITY OF THE COMPOSITE. SCANNING ELECTRON MICROSCOPY, ENERGY DISPERSIVE SPECTROSCOPY, X-RAY DIFFRACTION ANALYSIS AND ROOM TEMPERATURE TENSILE TESTS WERE CARRIED OUT ON SPRAYED COMPOSITE MONOTAPES. THE LONG RAGE DIFFUSION OF CHEMICAL REACTIONS PRODUCTS IN THE INTERFACIAL ZONE WAS INVESTIGATED, AFFECTING MECHANICAL PROPERTIES OF THE COMPOSITE, WITH SPECIAL REFERENCE TO ULTIMATE TENSILE STRENGTH AND STRAIN. PLASMA SPRAYING FABRICATION METHOD SEEMS PROMISING IN REDUCING COST AND IMPROVING QUALITY OF THE FINAL PRODUCTS. THE WIDESPREAD APPLICATION OF LPPS AS A PRODUCTION TECHNIQUE FOR MMCS CAN BE ANTICIPATED. NEVERTHELESS FURTHER RESEARCH AND DEVELOPMENT ACTIVITIES ARE REQUIRED TO REVEAL AND TO REALIZE THE TRUE POTENTIAL OF THESE MATERIALS
Stakeholder engagement in managing systemic risk management
No full textThis paper employs the interpretative lens provided by stakeholder theory to garner novel insights for research and managerial practices within the framework of high-reliable organizations (HROs). It proposes an interpretative matrix for analyzing and explaining how stakeholders’ behaviors and interactions can transition from a “strategic” to a “responsibility” approach in the context of risk management. The paper adopts a qualitative methodology based on a case study of the Italian Civil Protection—an HRO—during the COVID-19 pandemic. Through the analysis of institutional sources and reports, we apply two theoretical frameworks to examine how the organization's engagement strategy changed in response to an unexpected event. This case serves to illuminate the main implications and practical applications of shared conceptual reflections. The principal implications are traced in terms of theory, practice, and policy, focusing on the joint examination of organizational reliability and stakeholder engagement theory, the potential utility of the proposed case study, and the feasible policy actions. The main limitations of this study lie in the purely qualitative methodology employed, the nature of the organization analyzed, and the territorial scope of the study. Future works will address an empirical investigation of the theoretical relations uncovered herein, as well as the expansion of the spectrum of analysis (e.g., private organizations) and a cross-country widening of the level of analysis
The role of the prefrontal cortex in familiarity and recollection processes during verbal and non verbal recognition memory: a rTMS study.
No full textNeuroimaging and lesion studies have documented the involvement of the frontal lobes in recognition memory. However, the precise nature of prefrontal contributions to verbal and non-verbal memory and to familiarity and recollection processes remains unclear. The aim of the current rTMS study was to investigate for the first time the role of the DLPFC in encoding and retrieval of non-verbal and verbal memoranda and its contribution to recollection and familiarity processes. Recollection and familiarity processes were studied using the ROC and unequal variance signal detection methodologies. We found that rTMS delivered over left and right DLPFC at encoding resulted in material specific laterality effects with a disruption of recognition of verbal and non-verbal memoranda. Interestingly, rTMS over DLPFCs at encoding significantly affected both recollection and familiarity. However, at retrieval rTMS did not affect recollection and familiarity. Our results suggest that DLPFC has a degree of functional specialisation and plays an important role in the encoding of verbal and non-verbal memoranda
Exploring the nexus between ESG risk variations and investment preferences: Insights from sustainable ETFs during the COVID-19 era
No full textThis study analyzes the impact of Environmental, Social, and Governance (ESG) risk metrics on the financial performance of ETFs in the US and Europe from January 2020 to December 2023, particularly during the COVID-19 pandemic. It explores the influence of ESG investment trends on ETF performance and investor preferences between equities and bonds in response to ESG risk profiles. Results show a positive correlation between higher ESG standards and financial performance, measured by the Sharpe ratio, with a marked preference for bonds amidst increased ESG risks. This highlights the critical role of ESG considerations in investment strategies and risk management, providing insights for sustainable finance
Advanced carcinoma of the cervix treated by continuous pelvic arterial infusion with cytostatics and radiation therapy.
No full textTelomerase as a marker of tumor cell viability: A new approach for in vitro chemosensitivity assays?
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