29 research outputs found
Bone Metastasis From Gastric Cancer: The Incidence, Clinicopathological Features, and Influence on Survival
No full textPubMedScopu
Gender-Based Analysis of Electrocardiographic Parameters:Utilizing Machine Learning Feature Selection Methods in ClassifyingCases of Heart Failure with Preserved Ejection Fraction
No full textHeart failure is a significant health issueworldwide, causing high morbidity and mortality. Cases of heart failure withpreserved ejection fraction (HFpEF), particularly among women, are on the rise ADDIN EN.CITE ADDIN EN.CITE.DATA 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The dataset used inthis study includes information on 26 different parameters for 52 male and 66female patients (n=118) over the age of 18, who presented to the CardiologyDepartment of Samsun Training and Research Hospital between November 2022 andAugust 2023. Gender-specific electrocardiographic (ECG) parameters were used toclassify HFpEF patients using machine learning methods (Gradient Boosting, K-NearestNeighbors, Logistic Regression, Random Forest ve Support Vector Machines ADDIN EN.CITE <EndNote><Cite><Author>Yilmaz</Author><Year>2023</Year><RecNum>6</RecNum><DisplayText>(3)</DisplayText><record><rec-number>6</rec-number><foreign-keys><keyapp="EN" db-id="5x2ztfs5rz2xfyera0ap2d9tpffewx0p2dsv"timestamp="1700142945">6</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Yilmaz,Rustem</author><author>Öz,Ersoy</author></authors></contributors><titles><title>Comparisonof Electrocardiographic Parameters by Gender in Heart Failure Patients withPreserved Ejection Fraction via ArtificialIntelligence</title><secondary-title>Diagnostics</secondary-title></titles><periodical><full-title>Diagnostics</full-title></periodical><pages>3221</pages><volume>13</volume><number>20</number><dates><year>2023</year></dates><isbn>2075-4418</isbn><urls><related-urls><url>https://doi.org/10.3390/diagnostics13203221</url></related-urls></urls><electronic-resource-num>10.3390/diagnostics13203221</electronic-resource-num></record></Cite></EndNote>(3). Various model dependent and modelagnostic feature selection techniques were applied to the ECG parameters tocreate different feature sets ADDIN EN.CITE<EndNote><Cite><Author>Paksoy</Author><Year>2022</Year><RecNum>120</RecNum><DisplayText>(4)</DisplayText><record><rec-number>120</rec-number><foreign-keys><keyapp="EN" db-id="5x2ztfs5rz2xfyera0ap2d9tpffewx0p2dsv"timestamp="1713188965">120</key></foreign-keys><ref-typename="Journal Article">17</ref-type><contributors><authors><author><styleface="normal" font="default"size="100%">P</style><style face="normal"font="default" charset="162"size="100%">aksoy</style><style face="normal"font="default" size="100%">,Nur</style></author><author><style face="normal"font="default" size="100%">Y</style><styleface="normal" font="default" charset="162"size="100%">a</style><style face="normal"font="default" charset="238"size="100%">ğı</style><style face="normal"font="default" charset="162"size="100%">n</style><style face="normal"font="default" charset="238" size="100%">,FatmaHilal</style></author></authors></contributors><titles><title>Artificialintelligence-based colon cancer prediction by identifying genomicbiomarkers</title><secondary-title>MedicalRecords</secondary-title></titles><periodical><full-title>MedicalRecords</full-title></periodical><pages>196-202</pages><volume>4</volume><number>2</number><dates><year>2022</year></dates><isbn>2687-4555</isbn><urls></urls><electronic-resource-num>10.37990/medr.1077024</electronic-resource-num></record></Cite></EndNote>(4). The highest classification accuracy(79%) was achieved using the Gradient Boosting method. The most influentialfeatures in this classification were smoking, P-wave duration, age, P-wave amplitudeand left ventricular end-systolic diameter. Machine learning has the potentialto enhance accuracy in diagnosing by highlighting the importance ofgender-specific ECG parameters in HFpEF patients, offering personalizedapproaches in disease management. The use of this technology will enable thedevelopment of more precise diagnostic and treatment strategies in cardiologypractice.</p
Prognostic factors in patients with metastatic urothelial carcinoma who have treated with Atezolizumab
No full textBackground Atezolizumab (ATZ) has demonstrated antitumor activity and manageable safety in previous studies of patients with metastatic platinum-resistant urothelial carcinoma. However, the response rate of Atezolizumab was modest. In the current study, we evaluated the pretreatment prognostic factors for overall survival in patients with metastatic urothelial carcinoma who have progressed after first-line chemotherapy in the Expanded-Access Program of Atezolizumab. Patients and methods In this study, we present a retrospective analysis of 113 patients with urothelial cancer treated with ATZ after progression on first-line chemotherapy. Data of the patients was obtained from patient files and hospital records. Eligible patients included metastatic urothelial carcinoma patients treated with at least one course of ATZ. Univariate analysis was used to identify clinical and laboratory factors that significantly impact OS. Variables were retained for multivariate analysis if they had a statistical relationship with OS (p < 0.1), and then included a final model of p < 0.05. Results The median follow-up duration was 23.5 months. Of the patients, 98 (86.7%) were male and 13.3% were female. The median age was 65 years of age (37-86). In univariate analysis, primary tumor location in the upper tract, increasing absolute neutrophil count (ANC), increasing absolute lymphocyte count, neutrophil-to-lymphocyte ratio (NLR) > 3, liver metastases, baseline creatinine clearance less (GFR) than 60 ml/min, Eastern Cooperative Oncology Group (ECOG) performance status (1 >=), and hemoglobin levels below 10 mg/dl were all the significantly associated with OS. Three of the five adverse prognostic factors according to the Bellmunt criteria were independent of short survival: liver metastases HR 3.105; 95% CI 1.673-5.761; p < (0.001), ECOG PS (1 >=) HR 2.184; 95% CI 1.120-4.256; p = 0.022, and Hemoglobin level below 10 mg/dl HR 2.680; 95% CI 1.558-4.608; p < (0.001). In addition, NLR > 3 hazard ratio [HR] 2.092; 95% CI 1.031-4.243; p = 0.041 and GFR less than 60 ml/min HR 1.829; 95% CI 1.1-3.041; p = 0.02, maintained a significant association with OS in multivariate analysis. Conclusions This model confirms the Bellmunt model with the addition of NLR > 3 and GFR less than 60 ml/min and can be associated with clinical trials that use immunotherapy in patients with bladder cancer
Clinical Significance of HER2 Overexpression in Gastric and Gastroesophageal Junction Cancers
No full textIn this study, we investigated the rate of human epidermal growth factor receptor 2 (HER2) overexpression in gastric (GC) and gastroesophageal junction cancers (GEJCs) and the relationship with HER2 expression and clinical, pathological parameters and prognosis. Surgery or biopsy specimen of 598 (436 males, 162 females) patients with GC or GEJC was evaluated for the presence of HER2 overexpression by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) methods. HER2 IHC scores were as follows: 418 (69.9 %) IHC 0, 58 (9.7 %) IHC 1+, 50 (8.4 %) IHC 2+, 72 (12 %) IHC 3+. Among 50 patients with IHC 2+, 18 (38.2 %) were FISH positive, and 29 (61.7 %) were FISH negative for HER2 amplification. Patients were regarded as HER2 positive in case of IHC 3+ disease or IHC 2+ disease with a positive FISH test result for HER2 amplification. In the primary analysis population, 90 (15 %) were considered HER2 positive. HER2 positivity was higher in intestinal GC compared to diffuse GC (16.9 vs 6.6 %, p = 0.014). HER2 positivity was significantly higher in well and moderately differentiated tumors than poorly differentiated tumors (p < 0.0001). HER2 positivity had no significant effect on median OS (23.2 vs 19.1 months, p = 0.44). But in the early stages (stages I and II), median OS of HER2-positive patients was shorter than HER2-negative patients (51.4 months vs not reach, p = 0.047). However, median OS was similar in patients with advanced stages (stages III and IV) HER2-positive and HER2-negative disease (16.2 vs 13.7 months, p = 0.72). Rate of HER2 positivity is similar in Turkish patients with GC and GEJCs. HER2 positivity is associated with poor prognosis in patients with early-stage disease
Progression-free survival of patients according to LPI.
No full text<p>Progression-free survival of patients according to LPI.</p
Results of univariate and multivariate Cox's proportional hazard models regarding OS.
No full text<p><i>OS</i> overall survival, <i>HR</i> hazard ratio, <i>CI</i> confidence interval, <i>LPI</i> laboratory prognostic index, <i>ECOG</i> Eastern Cooperative Oncology Group, <i>PS</i> performance status, <i>WBC</i> White Blood Cell count, <i>LDH Lactate dehydrogenase, ALP</i> Alkaline phosphatase.</p><p>Results of univariate and multivariate Cox's proportional hazard models regarding OS.</p
Overall survival of patients according to LPI.
No full text<p>Overall survival of patients according to LPI.</p
Outcomes of Adolescent and Adult Patients with Lung Metastatic Osteosarcoma and Comparison of Synchronous and Metachronous Lung Metastatic Groups.
No full textOsteosarcomas with lung metastases are rather heterogenous group. We aimed to evaluate the clinicopathological characteristics and outcomes of osteosarcoma patients with lung metastases and to compare the synchronous and metachronous lung metastatic groups. A total of 93 adolescent and adult patients with lung metastatic osteosarcoma, from March 1995 to July 2011, in a single center, were included. Sixty-five patients (69.9%) were male. The median age was 19 years (range, 14-74). Thirty-nine patients (41.9%) had synchronous lung metastases (Group A) and 54 patients (58.1%) had metachronous lung metastases (Group B). The 5-year and 10-year post-lung metastases overall survival (PLM-OS) was 17% and 15%, respectively. In multivariate analysis for PLM-OS, time to lung metastases (p = 0.010), number of metastatic pulmonary nodules (p = 0.020), presence of pulmonary metastasectomy (p = 0.007) and presence of chemotherapy for lung metastases (p< 0.001) were found to be independent prognostic factors. The median PLM-OS of Group A and Group B was 16 months and 9 months, respectively. In Group B, the median PLM-OS of the patients who developed lung metastases within 12 months was 6 months, whereas that of the patients who developed lung metastases later was 16 months. Time to lung metastases, number and laterality of metastatic pulmonary nodules, chemotherapy for lung metastatic disease and pulmonary metastasectomy were independent prognostic factors for patients with lung metastatic osteosarcoma. The best PLM-OS was in the subgroup of patients treated both surgery and chemotherapy. The prognosis of the patients who developed lung metastases within 12 months after diagnosis was worst
Risk Factors of Nasopharyngeal Carcinoma in Turkey - an Epidemiological Survey of the Anatolian Society of Medical Oncology
No full textBackground: Nasopharyngeal carcinoma is a rare disease in most parts of the world with a multifactorial etiology involving an interaction of genetic, viral, environmental and dietary risk factors. This is the first epidemiologic study aimed to evaluate the risk factors of nasopharyngeal carcinoma in the Turkish population. Methods: We conducted a multicentric, retrospective, case-control study using a standardized questionnaire which captured age, sex, occupation, household type, blood group, dietary habits, smoking, alcohol consumption and oral hygiene. The study included 183 cases and 183 healthy controls matched by sex and age. Multiple logistic regression and univariate analysis were employed. Results: The peak age incidence was 40-50 years and the male to female ratio was 2:1. We observed significant associations between elevated nasopharyngeal carcinoma risk and low socioeconomic status, rural household type (OR: 3.95, p0.05); furthermore salty foods had a borderline p value (OR: 2.14, p=0.053). Blood type A increased the risk (OR: 2.03, p=0.002) while blood type 0 was a protective factor (OR: 0.53, p=0.009). Rare habit of teeth brushing (OR: 6.17, p= 10 decayed teeth before diagnosis (OR: 2.17, p<0.001) increased the risk. Conclusions: The nasopharyngeal carcinoma risk factors described in the literature are also applicable for the Turkish population. People with type A blood are at risk in Turkey. Salted foods have also a border risk out of the endemic regions. This is the only study showing that poor oral hygene is a serious risk factor for nasopharyngeal carcinoma
Overall Survival according to patient characteristics and LPI.
No full text<p><i>LPI</i> laboratory prognostic index, <i>ECOG</i> Eastern Cooperative Oncology Group, <i>PS</i> performance status.</p><p>Overall Survival according to patient characteristics and LPI.</p
