1,721,005 research outputs found
Ingegneria chimica e dispositivi di supporto epatico: una nuova applicazione di metodologie consolidate
No full textRemoval of albumin-bound toxins from albumin-containing solutions: Tryptophan fixed-bed adsorption on activated carbon
No full textFixed-bed adsorption on activated carbon is a common blood detoxification technique implemented in liver support devices to remove different types of toxins, among which is tryptophan. In this paper, fixed-bed adsorption kinetics of tryptophan on activated carbon were investigated. Experimental tryptophan breakthrough curves were obtained at different feed flow rates, both in albumin-free and albumin-containing solutions. A mathematical model based on linear driving force mass transfer kinetics was used to correlate data obtained with albumin-free solutions; subsequently, the results were successfully used to predict tryptophan breakthrough curves obtained with albumin-containing solutions, accounting only for the effect of albumin over tryptophan adsorption equilibrium. (C) 2009 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved
ALBUMIN-BOUND TOXIN REMOVAL IN LIVER SUPPORT DEVICES: CASE STUDY OF TRYPTOPHAN ADSORPTION AND DIALYSIS
No full textG.Marino, E. Bardone, A. Viglia Ed
Carbon Formation in the Steam Reforming Process: a Thermodynamic Analysis Based on the Elemental Composition
No full textBilirubin removal from albumin-containing solutions: dynamic adsorption on anionic resin
No full textIn this paper, kinetics of unconjugated bilirubin adsorption in fixed-bed anionic resin columns was investigated. Experimental breakthrough curves were determined at different feed flow rates and using inlet solutions with different bilirubin and albumin concentrations. A mathematical model is provided to describe the effect of albumin on bilirubin adsorption equilibrium and kinetics in a fixed-bed column. Breakthrough curves show that a significant bilirubin concentration is present in the column outlet stream even in the early operating time. This result shows that, with the flowrates used in this work, adsorption is slow with respect to the axial convection in the column and, as a consequence, bilirubin is never completely removed from the liquid phase. The results obtained in this paper may be useful for the design of liver support devices such as Molecular Adsorbent Recirculating System (MARS), which implement anion-exchange columns to remove albumin-bound toxins from concentrated albumin solutions. (C) 2009 Curtin University of Technology and John Wiley & Sons, Ltd
Simultaneous removal of albumin-bound toxins in liver support devices: bilirubin and tryptophan adsorption on activated carbon
No full textAdsorption processes are commonly implemented in liver support devices for the removal of albuminbound
toxins such as bilirubin andtryptophan.A quantitative knowledge of the reduction of the adsorption
capacity due to the simultaneous presence of albumin and several toxins in the liquid phase is essential for
a rational design of an adsorption unit used in the liver support devices.In this work, simultaneous
adsorption of bilirubin and tryptophan from albumin-containing solutions was investigated. In particular,
experimental runs have been carried out in order to evaluate the presence of a competitive adsorption on
the activated carbon of the two examined toxins. The IAS model has been used to account for
multicomponent adsorption equilibrium
Albumin-Bound Toxin Removal in Liver Support Devices: Case Study of Bilirubin Adsorption and Dialysis
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