221 research outputs found
Stroke prevention in the elderly atrial fibrillation patient with comorbid conditions: focus on non-vitamin K antagonist oral anticoagulants
No full textMohit K Turagam, Poonam Velagapudi, Greg C FlakerDivision of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO, USAAbstract: Stroke prevention in elderly atrial fibrillation patients remains a challenge. There is a high risk of stroke and systemic thromboembolism but also a high risk of bleeding if anticoagulants are prescribed. The elderly have increased chronic kidney disease, coronary artery disease, polypharmacy, and overall frailty. For all these reasons, anticoagulant use is underutilized in the elderly. In this manuscript, the benefits of non-vitamin K antagonist oral anticoagulants compared with warfarin in the elderly patient population with multiple comorbid conditions are reviewed.Keywords: non-vitamin K antagonist oral anticoagulants, novel oral anticoagulants, warfarin, dabigatran, rivaroxaban, apixaban, edoxaba
ASIP data-plane processor for multi-standard wireless protocol processing
No full textEvolving Multi-Protocol Multi-Band Software Defined Radio (SDR) devices aim at supporting multiple protocols seamlessly and efficiently. The design of such radios necessitates flexibility in physical layer processing, flexibility in routing packets through processing engines and flexibility in radio frequency reception/transmission. This dissertation addresses an efficient implementation of flexible physical layer processing (PHY) for Interleaving, De-Interleaving and linear Minimum Mean Square Error (MMSE) detection in Multiple Input Multiple Output (MIMO) receivers through Application Specific Instruction Set Processors (ASIPs). The thesis defines and develops a WINLAB cognitive radio (WiNC2R) compatible data-plane ASIP architecture along with suitable hardware-software partitioning of the Processing Engine unit. Given the requirement of very significant design time and the lack of the flexibility after design, dedicated ASIC for PHY may not be a viable option although it has the best performance among all available options. The software application running on general purpose processor cannot satisfy the throughput requirements of the wireless standards. ASIPs provide a better trade-off between flexibility and performance, with the advantage of considerably lower design time than ASICs. We design an efficient multi-standard (802.11a, 802.16e/m) supporting Interleaver/De-Interleaver ASIP, satisfying the throughput requirements for all the modulation-schemes/data-rates in both of the standards. It can be programmed to scale for supporting future wireless standards (that use Block Interleaving/De-Interleaving). We also study viability of a flexible MIMO MMSE detector ASIP supporting variable MR (Number of receiving antennas) * MT (Number of transmitting antennas) operations. We have analyzed the implementation of an hardware-centric algorithm for MIMO detection on an ASIP and also improved its performance with the help of techniques such as fixed point implementation, Single Instruction Multiple Data (SIMD) and Very Long Instruction Word (VLIW). Analysis of the design performance results for MIMO ASIP indicates the limitations of hardware-implementation-specific algorithms on ASIP. We also provide the account of design decisions such as custom ports, memory interfaces and registers that are added to the data-plane processor ASIPs in order to substitute them for dedicated hardware engines in the WiNC2R platform.M.S.Includes bibliographical referencesby Mohit Gopal Wan
Context-Driven Engineering Learning Model (CDELM): Companion Teaching Resource and Applied Decision Framework
No full textThis Open Science Framework (OSF) project documents the Context-Driven Engineering Learning Model (CDELM), a structured pedagogical framework integrating engineering education with applied decision-making, managerial reasoning, and real-world contextual triggers.
The project serves as a companion academic resource aligned with the Zenodo DOI publication and associated implementation materials. It includes conceptual structure, applied classroom scenarios, framework architecture, and decision-context mapping methodology designed for engineering and management education.
This repository supports transparent dissemination, academic reproducibility, and open scholarly visibility.
Associated DOI:
https://doi.org/10.5281/zenodo.18604436
Author:
Mohit Tiwari
Assistant Professor, Department of Computer Science & Engineering
Bharati Vidyapeeth's College of Engineering, Delhi, Indi
Implantable cardioverter‐defibrillator in patients with spontaneous coronary artery dissection presenting with sudden cardiac arrest
No full textIntroduction: The role of secondary prevention implantable cardioverter-defibrillator (ICD) remains uncertain in spontaneous coronary artery dissection (SCAD) patients presenting with sudden cardiac arrest (SCA). Methods: We aimed at assessing the outcomes following SCA and the role of ICD therapy in SCAD. The meta-analysis was performed using a meta-package for R version 4.0/RStudio version 1.2 and the Freeman–Tukey double arcsine method to establish the variance of raw proportions. Outcomes measured included—(1) incidence of ICD implantation, (2) appropriate and inappropriate ICD therapy, (3) recurrence of SCAD and SCA, and (4) all-cause mortality. Results: Five studies, including 139 SCAD patients with SCA met study inclusion criteria. The mean age was 47.3 ± 12.8 years, mean left ventricular ejection fraction 43.8 ± 10.8%, 88% were female (12% had pregnancy-associated SCAD. Causes of SCA included ventricular arrhythmia (97.9%, n = 136) and pulseless electrical activity (2.1%, n = 3). Overall, 20% patients (95% confidence interval [CI]: 7.1%–36.6%, I2 = 68%) received ICD, of which 1.2% (95% CI: 0%–15.8%, I2 = 0%) and 1% (95% CI: 0%–15.3%, I2 = 0%) patients received appropriate and inappropriate ICD therapies, respectively, during follow-up period (4.1 ± 3.3 years). Incidence of recurrent SCAD was 9% (95% CI: 2.85%–17.5%, I2 = 25%), and recurrent SCA was 3.85% patients (95% CI: 0.65%–8.7%, I2 = 0%; one patient with appropriate ICD therapy). The pooled incidence of all-cause mortality was 6.2% (95% CI: 0.6%–15.1%, I2 = 44%). Conclusion: Although ICD therapy is beneficial in patients (all comers) presenting with cardiac arrest; the risk-benefit ratio of secondary prevention ICD arrest remains unclear. Patient-centered shared decision-making and risk-benefit ratio assessment should be performed before consideration for ICD implantation
Author Correction: Closed-loop brain training: The science of neurofeedback
No full textIn this article, the affiliation for Mohit Rana was incorrectly listed as the Institute for Biological and Medical Engineering, Department of Psychiatry, and Section of Neuroscience, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860 Hernán Briones, piso 2, Macul 782–0436, Santiago, Chile. The listed affiliation should have been the following: Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de Chile, Santiago, Chile; and the Laboratory for Brain-Machine Interfaces and Neuromodulation, Pontificia Universidad Católica de Chile, Santiago, Chile. An acknowledgement to Mohit Rana’s funding source was also missing. The following sentence should have been included in the acknowledgments section: M.R. is supported by a Fondecyt postdoctoral fellowship (project no. 3100648
Anatomical and electrical remodeling with incomplete left atrial appendage ligation: Results from the LAALA-AF registry
No full textPercutaneous left ventricular assist device support during ablation of ventricular tachycardia: A meta‐analysis of current evidence
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