11 research outputs found
The failure of organized religion in Laurence Sterne's Tristram Shandy
No full textThis thesis is an examination of Laurence Sterne's Tristram Shandy, in which the author shows that Sterne's fundamental concern with loneliness and mortality in Tristram significantly involves his belief that institutional religion--desiccated, corrupt, and ineffectual--is unable to help. Instead of providing strength, solace, inspiration, and communion, churches are decidedly human institutions comprised of the eccentric, the stupid, and the venal. Many references in the novel make it clear that religion--as Sterne sees it practiced by Anglicans and Catholics alike--is no remedy for one's loneliness or fear of death
The Failure of Organized Religion in Laurence Sterne's Tristram Shandy
No full textThis thesis is an examination of Laurence Sterne's Tristram Shandy, in which the author shows that Sterne's fundamental\ud
concern with loneliness and mortality in Tristram\ud
significantly involves his belief that institutional\ud
religion--desiccated, corrupt, and ineffectual--is\ud
unable to help. Instead of providing strength, solace,\ud
inspiration, and communion, churches are decidedly human\ud
institutions comprised of the eccentric, the stupid, and\ud
the venal. Many references in the novel make it clear\ud
that religion--as Sterne sees it practiced by Anglicans\ud
and Catholics alike--is no remedy for one's loneliness or\ud
fear of death
Obituary − Emeritus Professor Dr John Davidson McCraw (1925−2014) MBE, MSc NZ, DSc Well, CRSNZ, FNZSSS.
No full textJohn McCraw was an Earth scientist who began working as a pedologist with Soil Bureau, DSIR, then became the Foundation Professor of Earth Sciences at the University of Waikato in Hamilton, inspiring a new generation to study and work in Earth sciences . In retirement, John McCraw was an author and historian with a special emphasis on Central Otago as well as the Waikato region. Throughout his career, marked especially by exemplary leadership, accomplished administration, and commitment to his staff and students at the University of Waikato, John McCraw also contributed to the communities in which he lived through public service organizations and as a public speaker. He received a number of awards including an MBE, fellowship, and companionship, and, uniquely, is commemorated also with a glacier, a fossil, and a museum-based research room named for him. Emeritus Professor John McCraw passed away on the 14th of December, 2014. An obituary, entitled “Dedicated to earth science and his students”, was published in the Waikato Times on the 10th of January, 2015
The general as statesman : exploring the professional need for commanders to support viable political outcomes in peace and stability operations as typified by the UK military approach
No full textThe problem of theatre level politico-military arrangements during peace and stability operations is important because the intervening actors, working in complex and often ambiguous circumstances, need to calibrate the application of military and political means as a coherent interdependent whole. This is necessary in order to build peace, secure viable political outcomes and hence strategic successes; however it is not easy in practice. This thesis examines the hypothesis that, beyond their security-related tasks, military commanders should provide direct support to civilian interlocutors in order to facilitate and sustain the local political process. This requires military co-operation with other relevant actors, responsiveness to political direction and the specific shaping of military operations to impact decisively on political outcomes.
This work establishes that Western and United Nations doctrinal guidance extols political primacy and civil-military cooperation but does not fully explain the central importance of the political process, nor does it capture the potential peace building role of the military component. Analysis of practice in Kosovo, Iraq and Afghanistan, suggests that military commanders retain a uniquely influential position and have generally used their military means to positively influence political progress and help coordinate multi-dimensional plans. On occasion, to secure momentum and fill a void, commanders have quietly assumed a political function. Doctrine now needs to be refreshed to reflect practice. It should explain the military role in supporting the political process, elaborate the politico-military relationship as the inner core of a comprehensive approach to peace building and provide candid guidance on the difficulties to be expected where politico-military and coordination arrangements are incoherent. Moreover further work is needed on the wider application of this doctrine by the United Nations and the preparation of civilian leaders for politico-military relationships
Loss of Atrx affects trophoblast development and the pattern of x-inactivation in extraembryonic tissues
No full text© 2006 Garrick et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci. Mutations in ATRX provided the first example of a human genetic disease associated with defects in such proteins. To better understand the role of ATRX in development and the associated abnormalities in the ATR-X (alpha thalassemia mental retardation, X-linked) syndrome, we conditionally inactivated the homolog in mice, Atrx, at the 8- to 16-cell stage of development. The protein, Atrx, was ubiquitously expressed, and male embryos null for Atrx implanted and gastrulated normally but did not survive beyond 9.5 days postcoitus due to a defect in formation of the extraembryonic trophoblast, one of the first terminally differentiated lineages in the developing embryo. Carrier female mice that inherit a maternal null allele should be affected, since the paternal X chromosome is normally inactivated in extraembryonic tissues. Surprisingly, however, some carrier females established a normal placenta and appeared to escape the usual pattern of imprinted X-inactivation in these tissues. Together these findings demonstrate an unexpected, specific, and essential role for Atrx in the development of the murine trophoblast and present an example of escape from imprinted X chromosome inactivation
Uses of Wodan : The development of his cult and of medieval literary responses to it
No full textScholars working on Germanic pre-christian religion have generally considered Wodan to have been a deity of considerable importance to most if not all Germanic
tribes. This understanding is, however, based on a failure to approach the available evidence for Wodan within appropriate contemporary contexts. This thesis recontextualises the evidence, therefore, building a model of the general nature of Germanic heathenisms in the Migration Age, within which the cult of Wodan can be located. Set against this model, and with due consideration given to its social, political and religious contexts, the earliest evidence for Wodan can be seen as the beginning of a christian reimagination of this deity. A plausible model of Wodan's cult is established, which sees this cult as being geographically limited, and originating probably within the first half millenium of the Common Era; the cult of Odinn would appear, moreover, to be substantially separate in development from that of Wodan. Furthermore, a complex set of eighth-century scholarly re-uses of Wodan are shown to have shaped subsequent understandings of the deity, both in the medieval period and up to the present day.
Having considered how the traditions of eighth-century scholarship have misled modern scholarship, the thesis then examines the further development of these traditions
in Anglo-Saxon England. In this context, Wodan assumes still more various guises, and is conflated with Odinn, thus helping to cement modern scholarship's belief in the
original unity of these two figures. This process is strengthened, moreover, by the strong influence which Anglo-Saxon England exerted on Scandinavia both around the time of
the conversion of Scandinavia and at the period when much of the extant Scandinavian mythography was written down.
This Scandinavian mythography is examined briefly in the final chapter, which points out some important areas of misreading of pre-christian mythology in thirteenthcentury
Scandinavian mythography, as well as arguing for substantial extra-Scandinavian influences on such mythography. This leads, finally, to a consideration of how Odinn appears in what little certainly pre-christian evidence exists for him
A post-conquest English retrospect upon the age of the Anglo-Saxons : a study of the early-middle-English verse chronicle attributed to Robert of Gloucester.
No full textSIGLEAvailable from British Library Document Supply Centre-DSC:DXN019823 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
'Riot', 'Revolution' and 'Rape': The theatre relationship and performance breakdown
No full textThis thesis considers theories about the relationship between theatre makers and audience members in theatre – how this relationship is established and how it can break down. The thesis posits that the breakdown of a theatre relationship is manifested in audience behaviour which, when it is severe enough, can lead to interventions in performance and, potentially, the breakdown of that performance. The thesis argues that audience intervention in a performance constitutes a seizure of ‘performance power’ from the theatre makers, which is sufficiently difficult to achieve that successful and sustained interventions can only be carried out by groups of audience members and, probably, organized in advance. Further, the thesis suggests that in its most extreme form, such interventions may bring about a transfer of roles and power between audience members and theatre makers such that a new quasi-theatrical ‘performance of protest’ is created.
The thesis surveys three historical cases in which theatre performances were disrupted by deliberate audience interventions. In each case the nature of the intervention was slightly different and the effect upon the performance was also different. In the first example, the Plough and the Stars riots (Dublin, 1926) a preplanned protest occurred in the playhouse and, despite interruption, the performance continued. In the second instance, the audience at Living Theatre’s Paradise Now (California 1969) erupted in spontaneous protest within the theatre and the performance was almost entirely subsumed. In the final study, the Mervyn Thompson case (Auckland 1984) the protest took two forms: first there was a vigilante-style attack on Thompson himself which took place well away from any theatre event but had strong theatrical references; then several of his performances were affected by organized lobbying, pickets and interruptions. The thesis asks why the rupture in the theatre relationship occurred in each case and considers what these instances have to tell us about the breakdown of theatre performance as a social phenomenon.
The thesis finds that in all three cases the audience members carrying out the interventions belonged to pre-existing groups with prior experience in protest action. The thesis also finds that the protesters had all had direct experience of some other ‘dramatic’ or ‘theatrical’ event in their own lives; experiences that made the performance seem less relevant. Given this, the thesis argues that, in these cases, the propensity to disrupt was brought to the theatre relationship by the audience members rather than being a direct response to the performance, even where that performance was confrontational.
These findings have implications for theatre study and practice: in particular, the thesis raises questions about how we look at performance breakdown. Rather than assuming audience protest is a simple response to the performance, the findings suggest that such events must be considered in the light of the wider social and political context of the performance, most particularly the audience members’ pre-occupations. Finally, the thesis asks whether audience protest, however theatrical it appears, can ever become substitute theatre in the true sense of that word
The Transcriptomic and Genomic Analysis of Lamin A/C Expression in the Colon and in Colorectal Cancer
No full textLamins A and C, also known as A-type lamins, are type V nuclear intermediate filament proteins which form an interlacing meshwork of filaments subjacent to the inner nuclear membrane termed the nuclear lamina. A-type lamins have been implicated in DNA replication, gene transcription regulation, apoptosis, regulation of growth promoters and nuclear migration. Traditionally, expression of A-type lamins has been associated with differentiated cells. As such, mutations in A-type lamins have been associated with a diverse range of genetic diseases, including premature ageing syndromes and with increased proliferation, especially in tumours.
In colorectal cancer, expression of A-type lamins, have been shown to impart an adverse prognosis. In order to understand the underlying biological processes responsible for this adverse outcome in patients with colorectal cancer, I sought to clarify the expression profile of A-type lamins and their binding partners in normal colonic/rectal mucosa, prior to investigating the expression of A-type lamins in colorectal cancers. I used fresh tissue specimens obtained from patients with colorectal cancer for my experiments. A unique finding was the expression of lamin A in the putative stem cell niche of colonic / rectal mucosal crypts.
Further studies in the form of a microarray analysis, revealed a very complex picture of up regulation involving various signalling cascades in the cancer samples expressing A-type lamins. There was no evidence to suggest a direct involvement of A-type lamins influencing the Wnt signalling cascade, however, direct involvement of other signalling cascades, such as the IGF signalling cascade, Shh signalling cascade and TGF-β signalling cascades were noted. These signalling cascades were known to influence the Wnt signalling cascades and hence could play a crucial role in the pathogenesis of colorectal cancers expressing A-type lamins.
In addition to these important signalling cascades, other key genes involved in apoptosis, growth promoters, cell adhesion, stem cell regulation, oncogenes and tumour suppression, were noted to have a unique expression profile in the cancer sample expressing A-type lamins, not observed in the cancer sample lacking A-type lamin expression. These observations were suggestive of A-type lamins having a diverse range of actions via, as yet, undefined pathways. It would appear that A-type lamins were imparting a more motile, less adherent phenotype with stem cell like features in colorectal cancers expressing A-type lamins. This could explain the observed poor prognosis of patients with colorectal cancers expressing A-type lamins.
Creatine kinase brain (CKB), was also identified as an additional, potential, prognostic indicator in the Duke’s B group of patients with colorectal cancer expressing A-type lamins. This potential marker, in conjunction with A-type lamin expression could be used to identify a sub group of Duke’s B patients at high risk. Whether adjuvant therapy in this group would help improve their long term survival is unknown since no study has been done to assess this
Burden of HIV infection and HIV-associated morbidity in Zimbabwean adolescents
No full textThis thesis concerns the clinical epidemiology of HIV infection in Zimbabwean adolescents. Without treatment, there is a very high risk of death in the early years of life in HIV-infected infants. However, in recent years increasing numbers of adolescents have been presenting to health care services with symptomatic HIV infection and with features suggesting longstanding disease. Population-based surveys in Southern Africa have shown HIV prevalence rates among older children and adolescents to be much higher than would be anticipated if HIV-infants were not surviving early childhood. The burden and spectrum of HIV-associated morbidity among adolescents was investigated with two studies at secondary and primary care level, respectively. The main finding was of an extremely high prevalence of HIV infection at both levels of the health system, with HIV infection being the single most common cause of hospital admission and death among adolescents. Mother-to-child transmission was the most likely source of HIV infection in the majority, suggesting a substantial epidemic of older survivors of vertical HIV infection. Other countries with severe HIV epidemics may be experiencing a similar trend as their HIV epidemics mature. The lack of awareness of the possibility of survival to older childhood and adolescence with maternally-acquired, untreated HIV infection results in many missed opportunities for diagnosis, with HIV infection frequently not diagnosed until presentation with a severe HIV-related illness. The median CD4 count in 3 HIV-infected adolescents in primary care was 350cells/µl compared to a median CD4 count of 151cells/µl among hospitalised adolescents, suggesting that HIV testing in primary care identifies HIV-infected adolescents at an earlier stage of infection. Provider-initiated HIV testing and counselling in primary care was highly acceptable to adolescents and guardians. Provision of care has been adversely affected by under-appreciation of the numbers of surviving adolescents living with HIV, and the special needs of this age-group have not been distinguished from those of younger children. Young people who have acquired HIV perinatally are stigmatised by society who assume they must have acquired it through "bad" behaviour themselves, since it is not widely appreciated that long-term survival following vertical infection is possible. Immediate priorities are earlier diagnosis of HIV infection and improved management of HIV-infected adolescents. Possible areas of intervention are discussed in the final chapter. Similar studies are needed in neighbouring countries to investigate the generalisability of these findings
