200,802 research outputs found
RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease.
No full textRibonucleases play important roles in the RNA interference (RNAi) pathway. The Dicer endonuclease converts double-stranded (ds)RNA into small interfering (si)RNA and the Slicer endonuclease, as a component of the RNA induced silencing complex (RISC), cleaves mRNA. Tudor staphylococcal nuclease (Tudor-SN) is another component of RISC in humans, flies and nematodes and is therefore implicated in the RNAi pathway. Here, we explore the potential role of African trypanosome Tudor-SN in RNAi. First, we assembled tudor-sn null mutants and showed that the gene is dispensable for normal growth and for differentiation. Next, we developed an inducible RNAi reporter system and demonstrated that Tudor-SN is dispensable for RNAi. The kinetics of mRNA knock-down, protein knock-down and protein recovery following inactivation of dsRNA expression are all unperturbed in the absence of Tudor-SN. We conclude that if this nuclease plays a role in the destruction or processing of dsRNA, mRNA or siRNA in the RNAi pathway, it is likely a minor one
Watercolor painting of Harris Memorial Lodge by Paul Tudor Jones '32
No full textDigital image transferred from the Office of Communications to the College Archives in 2010.A watercolor of the Frank M. Harris Memorial Building by Rev. Paul Tudor Jones, Class of 1932
Tudor women writers fashioning masculinity
No full textThis thesis contributes to the growing interest in early modern masculinity and its literary representations by introducing texts by women writers into dialogue with their male-authored counterparts. It argues for a more nuanced approach that recognises that the concepts of masculinity and femininity can only be fully understood when studied in relation with each other.
The first chapter explores how, notwithstanding the wisdom of conduct books and marriage guides, the demands of the state may not always be commensurate with those of the domestic realm and shows that this conflict necessitates a rethinking of existing definitions of masculinity by focusing on selected writings of the Tudor sisters Mary and Elizabeth and Jane Fitzalan’s *Tragedie of Iphigeneia*. The second chapter identifies how Elizabeth’s unique discursive strategies were designed to elicit support from her male subjects and subdue the belligerence that simmered under polemic like John Stubbs’ *Gaping Gulf*. In her letters to Anjou, the chapter examines how Elizabeth manoeuvred around her position as a beloved and as a monarch to fashion a husband who would not only be sympathetic but also subordinate to her political authority. This chapter also shows how the fabulous world of John Lyly’s *Galatea* consummates the Queen’s desire for the ideal male subject. The final chapter investigates the construction of martial manhood. It juxtaposes Mary Sidney’s *The Tragedy of Antonie* with William Shakespeare’s *Antony and Cleopatra* to determine how the figure of Cleopatra, common to both plays, challenges and revises the martial code of masculinity as embodied by Antony. By examining the authorial position appropriated by Cleopatra in the plays and its impact on the narrative, this chapter also extends this thesis’ interest in the extent to which female characters within texts compete for diegetic control with male protagonists
Knights and knighthood in Tudor England
No full textPhDThe first chapters of this thesis attempt to isolate the factors
responsible for the making of a Tudor 1aiigt. Birth (noble and
gentle), education, wealth, conrtexiona, reli&.on, activity in
royal service, war, and the general auninons to take up knighthood
are all surveyed and, together with an analysis of the fluctuating
numbers of knights throughout the century, provide material f a
discussion of royal attitudes towards the honour,
Dubbing ceremonies and the occasions deemed suitable are next
described and a discussion of the aigniticance of the ceremonies
for both crown and subject is undertaken.
Finally, a study of the work of knights as members of
parliament, justices of the peace, sheriffs and deputy lieutenants
seeks to determine whether knights had taken up new duties to replace
the moribund military ones, and a brief conclusion suggests how and
wby knighthood was transformed during the century to survive the
decline of feudalism and chivalry
Tudor Hart, Julian & Thomas, Mary: transcript of an audio interview (14-Jun-2000)
No full textInterview with Dr Julian Tudor Hart and Ms Mary Thomas, conducted by Dr Andy Ness, for the History of Twentieth Century Medicine Research Group, UCL, 14 June 2000. Transcribed by Mrs Jaqui Carter, and edited by Professor Tilli Tansey and Dr Hugh Thomas. Dr Julian Tudor Hart (b. 1927) was an epidemiologist working in the Epidemiology Research Unit in 1960, before moving to general practice in 1961 until 1988. See also Mullan F. (1995) Interview with Julian Tudor Hart, February 1995. Primary Care Oral History Project, 1995–98. Modern Manuscripts Collection, National Library of Medicine, Bethesda, MD, USA. Dr Tudor Hart’s practice records from 1965 to 1992 are held as GP/13 in the Wellcome Library, London (for confidentiality, access to these records is subject to embargo).
Ms Mary Thomas (Mrs Hart) (b. 1940) was a fieldworker at the Medical Research Council Pneumoconiosis Research Unit from 1960 to 1962, and later for the MRC Medical Epidemiology and Medical Care Unit.The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity (no. 210183). The current interview was funded by a Wellcome Trust grant (059533; 1999-2001; awarded to Professor G Davey-Smith, Dr A R Ness and Dr E M Tansey), and its publication by a Wellcome Trust Strategic Award entitled “Makers of modern biomedicine: testimonies and legacy” (2012-2017; awarded to Professor Tilli Tansey)
Armed conflict and border society: The East and Middle Marches, 1536-60
No full textThe final phase of the Anglo-Scots Wars (1542-1560) significantly affected Northumberland. The Tudor government attempted to use the militarised society of Northumberland as a means of subduing Scotland. However, the ensuing conflict took a heavy toll on the Marchers. Instability plagued the region, while leading military families feuded with each other. The efforts of the Tudors were not concerted enough to overcome the Marchers' allegiance to kith and kin. March society proved to be remarkably inhospitable for Tudor state building, and in the end, the military community of Northumberland remained just as vulnerable to both internal and external threats as it had been before the wars. This work questions the success of Tudor state building տ the mid-sixteenth century. The analysis employs both State Papers and local documents to illuminate the political dialogue between central government and the peripheral frontier administration. Official correspondences of March officers also highlight the depths to which Tudor policy had taken root in Northumberland. An analysis of muster rolls suggests that Northumbrian society’s involvement in the wars greatly fluctuated over nearly a twenty-year period, only to see the military capacities of Northumbrians significantly wane by 1560. The personal testimonies of officers imply that the Tudors had some initial success in bringing significant military power to their side. However, the same documents also suggest that incoherent policies resulted from the rapid succession of three separate monarchs after the death of Henry VIIL In the end, the Tudor state was unable to instil order in Northumberland, and the military necessities of frontier security remained problematic for the rest of the sixteenth century
Conciliar politics and administration in the reign of Henry VII
No full textSince Elton's commentary on the absence of critical study of the early Tudor
council in 1964, some progress has been made towards a wider, fuller, more detailed
understanding of Henry VII's council and where it fits-or does not-into the
development of council under the Tudors. However, the early Tudor council remains
something of an enigma. Added to that is recent interest by late medieval historians
in just how much power Henry VII exercised in the operation of his councils. Was
Henry ruling, or were his bureaucratic counsellors ruling him? A re-examination of the
various Elizabethan/Jacobean council extracts, as well as the examination of data
contained in a wide variety of primary documents, such as the chamber account
books, petitions, privy seal warrants and view books, provides evidence with which to
suggest a more precisely defined and better organized council than that previously
established for the first Tudor monarch, and also to demonstrate that Henry VII was
actively involved in the business of the protean forms of that council, at Westminster
or away. This thesis hopefully advances the picture of the conciliar and administrative
matrix which was governing under Henry VII, its component parts, including an
embryonic privy council, the personnel of that council, the systems through which
conciliar business was developed, and the king's position at the head of that council in
the most literal sense
Dataset for: Modelling Reliable Electrical Conductors for E-Textile Circuits on Polyimide Filaments
No full textDataset supports: Komolafe, A., Torah, R., Tudor, M., & Beeby, S. (2020). Modelling reliable electrical conductors for e-textile circuits on polyamide filaments. In E-Textiles 2019: International Conference on the Challenges, Opportunities, Innovations and Applications in Electronic Textiles. Multidisciplinary Digital Publishing Institute (MDPI).</span
The marriage of Philip of Habsburg and Mary Tudor and anti-Spanish sentiment in England : political economies and culture, 1553-1557.
No full textPhDThis thesis examines the early part of Mary I's reign, focusing on her marriage to
Philip of Habsburg and the marginalisation of their co-monarchy in Tudor historiography.
By looking at the diplomatic background and political opposition in England, I interrogate
the notion that anti-Spanish sentiment was a central cause of the Wyatt rebellion, arguing that
instead its aetiology lay in female sovereignty and the constitutional uncertainties produced
by it. Dynasticism tended to alienate power from familiar, local and territorial sources of
political authority. Infant mortality and the vicissitudes of the marriage market in this context
threatened discrete 'national' identities with an incipient imperialist internationalism. I analyse
in detail the marriage contract and 'Act declaring that the regal power of this realm is in the
Queen's Majesty', using them as evidence to show that anxieties about property rights were
not related to the repudiation of the Supremacy, repeal of Henrician legislation and return of
papal jurisdiction. The staging of the wedding harped on Philip's inferior status, inverting that
which the marriage ceremony rehearsed. The Castilian writing of England as a romance of
chivalry sublimated a sexual licence which repeated the fears played upon by exiled
polemicists that the kingdom had been transformed into the feminised subject of Spanish
male authority. Anti-Spanish propaganda did not reflect popular xenophobia. It was literate
and sophisticated, related to sectarian struggle and engaged with theories of justifiable
disobedience. Finally, I treat the joint royal London Entry and representations of Philip and
Mary welcoming his assumption of authority in relation to both England and his new quee
An all-inkjet printed flexible capacitor on a textile using a new poly(4-vinylphenol) dielectric ink for wearable applications
No full textThis paper reports a flexible capacitor for wearable applications which has been all-inkjet printed on a standard 65/35 polyester cotton textile using a new poly(4 vinylphenol)(PVP) dielectric material. Capacitors form the basis of a variety of sensors, such as for proximity and touch, as well as electronic circuits. This paper reports a general fabrication printing process to realize capacitors on textiles. The parallel plate capacitor design uses a combination of heat curable silver ink and a new UV curable dielectric ink based on PVP, printed on to the textile. This new inkjet printable dielectric ink is ultra-violet (UV) cured for 100 seconds to achieve a thin dielectric film suitable for a textile based capacitor. After printing, the dielectric properties were measured and the cross-sectional film structure was observed using an SEM. The inkjet printed PVP film on the textile exhibited good insulating behavior and similar flexibility to the original textile
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