302 research outputs found
ANALISIS CAMPUR KODE DALAM LIRIK LAGU GENTLEMAN OLEH BOYBAND SHINEE KARYA JUNJI ISHIWATARI
No full text(Title: The Code Mix Analysis In Lyrics Of Shinee’s Gentleman By Junji Ishiwatari)
This study aims to analyze the code mix in the lyrics of SHINee’s Gentleman by Junji Ishiwatari which specifically to describe what kind of code mix is contained in the lyrics and to describe how the factors caused the interference of code in the lyrics. The method used in this research is observation and library research. There are 16 forms of code mix contained in the lyrics, namely: 5 insertion of elements of tangible word, 9 insertion of elements of the phrase and 2 insertion elements of tangible clause. The dominant form of code mix is the insertion of phrasal elements. While there are 3 factors that caused the interference of the code in the lyrics, namely: (1) The casuality (informal situation), (2) The author wants to show the learning and/or position and (3) There is no correctly expression in language that had been used. The dominant factor of them is no correctly expression in language that had been used. The customary factor is not found in the lyrics of SHINee’Gentleman by Junji Ishiwatari although songwriters often use English in writing song lyrics
T790M-selective EGFR-TKI combined with dasatinib as an optimal strategy for overcoming EGFR-TKI resistance in T790M-positive non-small cell lung cancer
No full text学位の種類：医学 学位授与年月日：平成30年3月20日 主査：西尾 和人 教授 報告番号：甲第1357号 学内授与番号：医第1248号
Satomi Watanabe, Takeshi Yoshida, Hisato Kawakami, Naoki Takegawa, Junko Tanizaki, Hidetoshi Hayashi, Masayuki Takeda, Kimio Yonesaka, Junji Tsurutani, and Kazuhiko Nakagawa Molecular Cancer Therapeutics, November 2017 Volume 16, Issue 11, DOI: 10.1158/1535-7163.MCT-17-0351 掲載application/pdfdoctoral thesi
La Atmósfera del Horror: Un Análisis de los Elementos Visuales en Tomie de Junji Ito
No full textINTRODUCTION
New Perspectives on Horror Manga
The primary objective of this study is to analyze Japanese horror comics, known as manga, through the works of Junji Ito, particularly Tomie. This author has become a central figure in the genre, and his work is essential for understanding how horror in manga achieves an impact that goes beyond its graphic elements, utilizing a distinctive visual and narrative style that creates a unique atmosphere and evokes profound emotions in its readers.
The analysis begins with a comparison between sequential horror media, such as happenings, and editorial media like comics, where the resources available are different: while the former include sound, characters in motion, and dynamic storytelling, comics must rely on visual strategies to achieve equally powerful horror effects. This research aims to explore the artistic evolution of Junji Ito and how, through the use and modification of lines and styles, he constructs atmospheres that immerse the reader in his narratives.
Throughout this study, the artistic styles that characterize horror manga will be examined, detailing the visual techniques that intensify the atmosphere, generate tension, and build unsettling narratives. The research seeks to answer a fundamental question: how is it possible to achieve, within editorial media—specifically horror comics—the same atmospheric effect that is present in sequential media?
This analysis of Junji Ito delves into the visual and narrative elements that define his style and have earned him a prominent place in horror manga. The study also considers the direct and indirect consequences of modifications in illustration on atmosphere and story development, highlighting the use of line work, onomatopoeia, and other essential resources for creating visual impact.
This work not only describes the influence of Junji Ito but also aims to serve as a guide for design and art students interested in illustration, providing tools to understand and construct effective atmospheres that instill in audiences a constant desire to explore further. In this sense, understanding Junji Ito’s style and techniques is fundamental for learning how to depict horror and tension within the realm of printed and editorial media.
Thesis for the Degree of Bachelor in Graphic Communication Design
INTRODUCCIÓN Nuevas perspectivas del manga de horror
Este trabajo tiene como propósito principal analizar el cómic de horror japonés, conocido como “manga”, a través de la obra de Junji Ito, particularmente Tomie. Este autor se ha convertido en una figura central en el género, y su trabajo es esencial para comprender cómo el horror en el manga logra un impacto que va más allá de sus elementos gráficos, usando un estilo visual y narrativo distintivo que crea una atmósfera única y despierta profundas emociones en sus lectores.
El análisis parte de la comparación entre los medios secuenciales de horror, como los happenings, y los medios editoriales como el cómic, donde los recursos son distintos: mientras los primeros cuentan con sonido, personajes en acción e historias en movimiento, los cómics requieren de estrategias visuales para alcanzar efectos de horror igualmente potentes. Esta investigación tiene como objetivo explorar los cambios en el arte de Junji Ito, y cómo, mediante el uso y la modificación de trazos y estilos, construye atmósferas que sumergen al lector en sus relatos.
A lo largo del trabajo, se examinan los estilos artísticos que caracterizan el manga de horror, detallando las técnicas visuales que intensifican la atmósfera, generan tensión y construyen narrativas perturbadoras. El estudio busca responder a una pregunta fundamental: ¿cómo es posible lograr en medios editoriales, específicamente en el cómic de horror, el mismo efecto atmosférico que se alcanza en los medios secuenciales?
En este análisis de Junji Ito se profundiza en los elementos visuales y narrativos que definen su estilo y le han dado un lugar destacado en el manga de horror. El estudio también considera las consecuencias directas e indirectas de las modificaciones en la ilustración sobre la atmósfera y el desarrollo de la historia, destacando el uso de líneas, onomatopeyas y otros recursos esenciales para crear impacto visual.
Este trabajo no solo describe la influencia de Junji Ito, sino que también busca servir como guía para aquellos estudiantes de diseño y arte interesados en la ilustración, proporcionando herramientas para entender y construir atmósferas efectivas que generen en el público un deseo constante de explorar más. En este sentido, comprender el estilo y las técnicas de Junji Ito es fundamental para aprender a plasmar el horror y la tensión en el ámbito de los medios impresos y editoriales.
Tesis para obtener el grado de Licenciada en Diseño de la Comunicación Gráficahttps://digitalcommons.njit.edu/stemshowcase/1097/thumbnail.jp
Análisis visual de las representaciones monstruosas en las obras de Junji ito, una mirada para la creación artística.
No full textEste proyecto tiene como objetivo la creación de una serie de obras a partir de dos conceptos, del término alemán unheimliche interpretado como, raro, siniestro o espeluznante, y de una reflexión acerca del trabajo del autor Junji Ito, quien ha plasmado dentro de sus obras representaciones fantásticas de la angustia. De igual forma, se busca señalar como el concepto de unheimliche es capaz de encontrarse dentro del arte, obras de horror y la sociedad actual. Finalmente, se explora la ejecución de la técnica al óleo, para hallar formas de interpretar problemáticas sociales y transformarlas en escenarios surrealistas.This project aimed to create a series of works based on two concepts, the German term unheimliche interpreted as weird, sinister or creepy, and a reflection on the work of the author Junji Ito, who has captured in his works fantastic representations of anguish. It also attempts to show how the concept of unheimliche is capable of being found within art, horror works and today's society. Finally, it explores the execution of the oil technique, to find ways to interpret social issues and transform them into surreal scenarios.PregradoLicenciado(a) en Artes Plástica
Abstract 1193: DS-8201a, a novel HER2-targeting ADC with a novel DNA topoisomerase I inhibitor, abrogates the resistance to T-DM1 in HER2-positive gastric cancer: a preclinical study
No full textAbstract
Background Anti-HER2 therapies are beneficial for patients with HER2-positive breast and gastric cancer. T-DM1 is an HER2-targeting antibody-drug conjugate (ADC), which is structurally composed of the anti-HER2 antibody trastuzumab and the tubulin inhibitor DM1. T-DM1 has shown efficacy in patients with advanced breast cancer, but all patients eventually develop resistance to T-DM1. DS-8201a is a novel ADC composed of an anti-HER2 antibody and a novel potent topoisomerase I inhibitor DX-8951 derivative. DS-8201a achieved a high drug-to-antibody-ratio (DAR: 7-8) and homogeneous drug conjugation. The aim of this study was to elucidate the mechanisms of T-DM1 resistance, and evaluate the efficacy of DS-8201a in a T-DM1-resistant HER2-positive gastric cancer cell line.
Materials and methods The T-DM1-resistant NCI-N87 cell line (N87-TDMR) was established by a step-wise method—the parent HER2-positive N87 cell line was exposed to up to 4 µg/ml of T-DM1. The profile of N87-TDMR was assessed by immunoblotting, DNA microarray, and quantitative reverse transcription-PCR (qRT-PCR). The sensitivity of parent N87 and N87-TDMR cells to T-DM1 or DS8201a was assessed by an in vitro growth inhibition assay as well as through the mouse xenograft model study.
Results N87-TDMR cells were found to be resistant to T-DM1 in the in vitro growth inhibition assay (50% growth inhibitory concentration; >10 µg/ml in N87-TDMR, 0.055 µg/ml in N87) as well as in the in vivo xenograft model study, but HER2 expression was maintained in the N87-TDMR cells. A comprehensive expression analysis revealed that N87-TDMR cells showed increased ATP-binding cassette (ABC) transporter expression such as ABCC2 and ABCG2 compared with N87 cells (50.2 times; 8.0 times higher than that measured by qRT-PCR relatively). Inhibition of ABCC2 and ABCG2 by MK571 recovered the sensitivity to T-DM1 in N87-TDMR cells. Since DS-8201a has higher DAR than T-DM1 and the unique topoisomerase I inhibitor, this resistance was expected to be abrogated. DS-8201a showed anti-tumor efficacy against N87-TDMR xenograft cells in the mouse model (relative tumor growth rate: 244.2% with T-DM1, -39.2% with DS-8201a; n=10 for each treatment).
Conclusions The HER2-positive gastric cancer cell line used in this preclinical study acquired resistance to T-DM1 depending on the up-regulation of ABCC2 and ABCG2 expression. However, DS-8201a could abrogate this T-DM1 resistance. These results provide a rationale for DS-8201a to be investigated for its efficacy in patients with T-DM1-resistant breast or gastric cancer.
Citation Format: Yoshikane Nonagase, Naoki Takegawa, Kimio Yonesaka, Kazuko Sakai, Yusuke Ogitani, Junji Tsurutani, Kazuto Nishio, Kazuhiko Nakagawa. DS-8201a, a novel HER2-targeting ADC with a novel DNA topoisomerase I inhibitor, abrogates the resistance to T-DM1 in HER2-positive gastric cancer: a preclinical study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1193. doi:10.1158/1538-7445.AM2017-1193</jats:p
Seven connection patterns between the author research areas.
No full textSeven connection patterns between the author research areas.</p
Recent Advances in the Development and Clinical Use of HER2 Inhibitors in Non-Small Cell Lung Cancer
No full textAlterations in the human epidermal growth factor receptor 2 (HER2) gene are well-recognized oncogenic drivers and therapeutic targets in non-small cell lung cancer (NSCLC). The first anti-HER2 inhibitor, trastuzumab-deruxtecan, was approved for previously treated advanced NSCLC with HER2 mutations, which accounts for 2–4% of NSCLC. The first anti-HER2 antibody, trastuzumab, was approved for HER2-positive metastatic breast cancer in 1998, and a combination therapy comprising trastuzumab, pertuzumab, and docetaxel demonstrated efficacy in the first-line setting. Some EGFR-tyrosine kinase inhibitors (TKIs) have been evaluated as pan-HER TKIs but have shown limited benefits in HER2-altered NSCLC. However, HER2-specific TKIs, such as zongertinib and BAY2927088, have demonstrated encouraging results. Zongertinib was the first HER2-specific TKI to be approved by the FDA in 2025 for previously treated ERBB2-mutated advanced NSCLC. In this narrative review, we have summarized the latest research on the biology of HER2 signaling, HER2 alterations, HER2-targeting therapies, and challenges of treating HER2-overexpressing or -mutated NSCLC. Despite different targets of HER2 mutations in NSCLC and HER2 amplification/overexpression in breast cancer, the development of HER2-targeting agents has been more advanced in breast cancer than in NSCLC. Therefore, pivotal clinical studies in breast cancer may help in identifying more effective therapies for NSCLC
Chemistry of High Polymers with Net Work Structure
No full textFolry's theory on the molecular weight distribution of three dimensional polymers is reviewed and its relationship with vulcanization of rubber is discussed. The elasticity of rubber is recently described by many workers. After Flory's theory, the elasticity is proportional to α-1/α2 where α is elongation ratio, and number of cress-linkages ν, while Kubo states that the elasticity is proportional to ν4/3, but Flory's opinion is more reasonable. The tensile strength of vulcanized rubber decreases linearly with reciprocal molecular weight of original rubbr, because of the network defect due to terminal chain. The vulcanzation lowers the concentration of terminal chain, but on the other hand has negative effect on account of its hindrance of crystallization on stretching. The theoretical equation for the tensile strength is propcsed, by which the maximum tensile strength is explained. The author discussed the reinforcing effect of filler, i.e. filler fixes rubber on its surface and acts as cross-linkage on stretching. The theoretical equation is introduced by author. Finally, the elastic property of plasticized polyvinyl-chloride is discussed. It is explained as visco-elasticity. Logarithm of elasticity decreases with prasticizer
Figurações de monstruosidade em Tomie, de Junji Ito
No full textJunji Ito é um importante desenhista e autor de mangás de horror, com cada vez mais obras suas sendo publicadas no Brasil e recebendo adaptações pelo mundo. Considerando essa relevância do autor, este trabalho buscou, de maneira qualitativa e analítica, com base na interpretação e análise bibliográfica, explorar as corporificações de Tomie nos três primeiros contos do volume 1 do mangá e, aliando elementos de outros contos da coleção, pensar sobre a personagem como objeto que tanto aterroriza quanto causa desejo em quem se envolve com alguma de suas formas. Discorreu-se sobre os três conceitos básicos que podemos atribuir às histórias de Tomie – horror, monstro e body horror –, definindo o gênero do horror a partir das ideias de Noël Carroll (1999), apoiando-se nos verbetes de Zanini (2019), no Dicionário Insólito Ficcional, para horror e monstro, e refletiu-se sobre os estudos de Xavier Aldana Reyes (2016) e Peter Hutchings (2008) a respeito do body horror e da construção de um corpo monstruoso. Buscou-se entender que tipo de manifestações monstruosas há em Tomie e de que maneira se articulam logo após seu assassinato, nos contos que dão início à série de reaparições seguintes. Compreendeu-se que a personagem figura um espírito vingativo, expressão vinda do folclore japonês; configura um monstro metamórfico; e que seu corpo materializa tanto o desejo quanto o desprezo pelo corpo feminino sentido pelas figuras masculinas.Junji Ito is a vital artist and author of horror manga, with more and more of his works being published in Brazil and receiving adaptations worldwide. Considering his relevance, this work sought to explore qualitatively and analytically, based on interpretation and bibliographic analysis, the first three stories of volume 1 of the manga, analyzing the embodiments of Tomie, and by combining elements from other stories in the collection we sought to think about the character as an object that both terrifies and causes desire in those who get involved with any of her forms. We discussed the three basic concepts that we could attribute to Tomie's stories – horror, monster, and body horror –, defining the genre of horror by the ideas of Noël Carroll (1999), relying on the entries for "horror" and "monster" by Zanini (2019), in the Dictionary of Unusual Fiction, and we reflected on the studies of Xavier Aldana Reyes (2016) and Peter Hutchings (2008) regarding body horror and the construction of a monstrous body. We seek to understand what kind of monstrous manifestations are in Tomie and how they are articulated soon after her murder, in the short stories that begin the subsequent reappearances. We understand that the character is a vengeful spirit, an expression from Japanese folklore; that she is a metamorphic monster; and that her body materializes both the desire and the contempt for the female body felt by the male figures
がん化学療法におけるQuality of Lifeの向上に関する基礎及び臨床学的研究
No full text学位の種類：薬学 学位授与年月日：平成31年3月19日 主査：小竹,武 教授 報告番号：甲第1418号 学内授与番号：薬第155号
Masashi Yanae, Shinichiro Fujimoto, Kaori Tane, Maki Tanioka, Kimiko Fujiwara, Masanobu Tsubaki, Yuzuru Yamazoe, Yoshiyuki Morishima, Yasutaka Chiba, Shintaro Takao, Yoshifumi Komoike, Junji Tsurutani, Kazuhiko Nakagawa, Shozo Nishida, Increased risk of SSEs in bone-only metastatic breast cancer patients treated with zoledronic acid, Journal of Bone Oncology, Vol.8, 2017, Pages 18-22, https://doi.org/10.1016/j.jbo.2017.08.004. 掲載
ジェネリック研究にて受理済み(2018年11月6日)
Masanobu Tsubaki, Tomoya Takeda, Ryo-ta Asano, Tomoyuki Matsuda, Shin-ichiro Fujimoto, Tatsuki Itoh, Motohiro Imano, Takao Satou, Shozo Nishida, Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins, Toxicology in Vitro, Vol. 46, 2018, Pages 284-293, https://doi.org/10.1016/j.tiv.2017.10.019. 掲載application/pdfdoctoral thesi
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