158 research outputs found
Association of adiponectin gene variants and adiponectin level with ischemic stroke in a Chinese cohort
No full textpublished_or_final_versionMedicineMasterMaster of Philosoph
Genetic variants of obesity- and inflammation-related genes in hypertension: genetic association studiesusing candidate gene approach
No full textpublished_or_final_versionMedicineDoctoralDoctor of Philosoph
Insulinoma
No full textInsulinoma is the most common pancreatic islet cell tumor, usually presenting with symptoms of neuroglycopenia. Diagnosis depends on a high index of suspicion, together with the demonstration of endogenous hyperinsulinemic hypoglycemia. Although the requirement for preoperative localization is controversial, the minimally invasive but highly sensitive endoscopic ultrasonography allows for a more focused surgery, shorter exploration time, and the option of laparoscopic surgery. Intra-arterial calcium stimulation test can be considered in persistent or possibly multifocal disease. Intraoperative ultrasonography is also recommended to assist tumor localization and minimize complications. The use of a biostator or rapid insulin assays intraoperatively may be helpful if multiple lesions are present. The surgical cure rate for benign insulinomas approaches 100%. For those with residual or metastatic disease, symptomatic control can be achieved with diazoxide or somatostatin analogues. Multimodality therapy is usually required for metastatic disease: with control of hypoglycemia, prolonged symptom-free survival can be expected. (C) 2000 Lippicott Williams and Wilkins, Inc.link_to_subscribed_fulltex
Programming for an Automated Roll Book at the Computor Classrooms : Using a Pattern Scanning and Processing Language, 'awk'
No full textP(論文)The log-in record of the direct users of UNIX OS are stored in the system and can be referred by the "last" command. The author has tried to link the data with the class student lists by using the 'awk' language to check the attendance and the seats of the students in the classrooms. The 'awk' is a pattern scanning and processing language, collabaroted by Aho, Wein-berger and Kernighan till 1985. After making relatively primitive programs, "class" and "check" for mere one week result report, he could achieve at last to write a more useful data-base-like program "table" for the last seven week data, indicating the seat-numbers or "欠" (absent symbol in Japanese) of each student. The given range of student attendance can be reviewed retroactively by pushing backspace or control+H key. This program can be utilized naturally by other staff, only by revising #2 part of it. If this simple effort by an amateur staff could stimulate the students in the "IT-Age", it might give him a great pleasure.departmental bulletin pape
The suppressive effect of growth hormone excess on circulating leptin level is reversed by treatment with sandostatin LAR or transphenoidal surgery
No full textEffect of Sandostatin® LAR® on serum leptin levels in patients with acromegaly
No full textOBJECTIVE. Serum leptin levels are decreased in patients with acromegaly and rise after GH is normalized by surgical treatment. We have evaluated the effect of Sandostatin® LAR® on leptin levels in acromegalic patients since there are recent data to suggest that somatostatin, in addition to its GH lowering effect, also reduces serum leptin levels in humans. METHODS. Nineteen patients with active acromegaly were studied. Eleven patients received monthly injection of Sandostatin® LAR® and eight patients underwent transsphenoidal surgery. Serum concentrations of leptin, GH, IGF-1 and insulin were measured before and after treatment. RESULTS. Serum leptin concentrations were lower in patients with active acromegaly than controls matched for age, sex and body mass index (BMI) [2.79 μg/l (2.60) vs. 4.41 μg/l (5.07); median (interquartile range); P< 0.01]. A positive correlation between serum leptin concentrations and BMI was observed in the controls (r = 0.46, P < 0.05) but not in the acromegalic patients before treatment (r = 0.32, ns). In the group of patients treated with Sandostatin® LAR®, a marked reduction in GH and IGF-1 was achieved by week 8 and GH and IGF-1 remained suppressed throughout the 6 months of treatment. There was no change in BMI. A significant increase in leptin levels only became evident after 6 months of treatment [2.99 μg/l (2.60) vs. 4.21 μg/l (3.84), P< 0.05]. Leptin levels also significantly increased after transsphenoidal surgery [3.05 μg/l (5.73) vs. 5.19 μg/l (4.93), P< 0.05]. The positive correlation between serum leptin concentrations and BMI was restored in acromegalic patients both after treatment with Sandostatin® LAR® (r= 0.62, P < 0.05) and after surgery (r = 0.81, P < 0.05). CONCLUSION. Leptin concentrations were decreased in patients with active acromegaly and lowering GH by either Sandostatin® LAR® or transsphenoidal surgery led to an increase in leptin concentrations.link_to_subscribed_fulltex
Using the albumin-globulin ratio to identify individuals with elevated high-sensitivity C-reactive protein level and high cardiovascular risk
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