4,819 research outputs found
JC virus evolution and its association with human populations
Full text linkThe ubiquitous human polyomavirus JC (JCV) is a small double-stranded DNA virus that establishes a persistent infection, and it is often transmitted from parents to children. There are at least 14 subtypes of the virus associated with different human populations. Because of its presumed codivergence with humans, JCV has been used as a genetic marker for human evolution and migration. Codivergence has also been used as a basis for estimating the rate of nucleotide substitution in JCV. We tested the hypothesis of host-virus codivergence by (i) performing a reconciliation analysis of phylogenetic trees of human and JCV populations and (ii) providing the first estimate of the evolutionary rate of JCV that is independent from the assumption of codivergence. Strikingly, our comparisons of JCV and human phylogenies provided no evidence for codivergence, suggesting that this virus should not be used as a marker for human population history. Further, while the estimated nucleotide substitution rate of JCV has large confidence intervals due to limited sampling, our analysis suggests that this virus may evolve nearly two orders of magnitude faster than predicted under the codivergence hypothesis.</p
Effect of 5-aminolevulinic acid-mediated photodynamic therapy on MCF-7 and MCF-7/ADR cells
No full textCharacterization of a polyclonal antihapten antibody by affinity capillary electrophoresis
No full textOptimization of the solubilization and renaturation of fish growth hormone produced by Escherichia coli.
No full textSequence diversity of a gene encoding a putative primary sigma factor among Borrelia burgdorferi sensu lato strains.
No full textLaser Doppler scanning study of palmar skin perfusion for patients with hyperhidrosis before and after thoracic sympathectomy.
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Direct detection of bacterial pathogens in brain abscesses by polymerase chain reaction amplification and sequencing of partial 16S ribosomal deoxyribonucleic acid fragments
No full textEscherichia coli-produced fish growth hormone as a feed additive to enhance the growth of juvenile black seabream (Acanthopagrus schlegeli).
No full textNeuropsychiatric disturbances and hypopituitarism after traumatic brain injury in an elderly man
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