74 research outputs found
Is unitary and integral Yugoslavia possible?
No full textTitle: Bъзмοжнa πu e euòннa u uяπocmнa Юƨocπaeuя? Ha ƨpaнuyama мeжòy noπumuκama u фuπocoфuяma (Is unitary and integral Yugoslavia possible? On the borderline between politics and philosophy) Originally published: in the magazine Фuπocoфcκu npeƨπeò, IV, 1932, vol. III, pp. 197–227. Language: BulgarianThe excerpts used are from the original, pp. 213–214, 220, 221–223. About the author Dimitar Mihalchev [1880, Lozengrad (Tur. Kirklareli, present-day Turkey) – 1967, Sofia]: philosopher and diplom..
THE IDIOLECT OF REVEREND ECONOMOS DIMITAR POPNIKOLOV PETKANOV
No full textA less studied talented author and brother of the popular fiction writer Konstantin Petkanov, priest
Dimitar wrote in the 1950s. This publication analyzes several parameters of his idiolect: phonetic peculiarities (reflex of ѣ, ѫ,
ъ; epenthetic [l]; reflexes of the [tʃ] [dʒ] groups; phonetic dialectisms; phonetic doublets); morphological paradigm (case
inflections; noun form for number; dualis; nomina collectiva; extended Church Slavonic suffix for adjectives; dialectal and
contracted pronoun forms; a temporal system characterized by high frequency of the verbs in terms of origin, distribution and
stylistic differentiation); lexical specifics (in terms of origin, distribution and stylistic differentiation). Emphasis is placed on
those lexical layers that constitute and ditinguish the author’s language. Hapaxes (produced using morphological and non-
morphological methods), rare words, semantic transponents, dialectisms, colloquial vocabulary and foreign words are studied.
All linguistic phenomena are examined retrospectively and in comparison with the synchronous linguistic situation before and
after the orthographic reform of 1945 in order to highlight the innovative contribution and the mechanisms through which the
author enriched the contemporary Bulgarian vocabulary. Occasionalisms, dialectal and archaic units occur more often in
Petkanov’s poetic works than in his fiction. The source material has been excerpted from Volume 1 (January – March) and
Volume 2 (April – June) of the hagiographic tetralogy “The Year of Our Lord“ and the memoir “A Book about My Brother –
the Writer Konstantin N. Petkanov“, which were published a few years ago by Dimitar Petkanov’s heirs
Fingertip traumatic amputations in children. Treatment with semiocclusive foil dressings-preliminary results
No full textIntroduction: Traumatic fingertip amputations in childhood constitute 2% of all hand injuries in individuals under the age of 14. These injuries have a significant impact on the psychological and emotional well-being of both the children and their parents. The treatment is multifactorial, dependent on the severity and location of the injury, and can involve both conservative and surgical approaches.
Materials and Methods: The study involved 6 patients between the ages of 8 and 15 with fingertip amputations of the hand. The average duration of treatment with semi-occlusive dressings was between 3-4 weeks. The dressing was changed once a week, and after the final dressing, the border between the wound surface and healthy skin was treated with epithelializing ointments.
Results: The average duration of treatment was 20-30 days. On average, dressings were changed 3-5 times throughout the treatment period. After the completion of treatment, the pulp had a normal shape, and the cosmetic outcome was excellent. No contractures were observed in the adjacent joints, and the two-point discrimination test had an average value of 2.5 mm.
Discussion: Fingertip amputations present challenging injuries with multiple available treatment strategies. The presented technique is relatively simple to apply, reduces pain and discomfort, and allows direct visualization of the wound surface without the need for frequent dressing changes. Treatment with semi-occlusive dressings is a minimally invasive method, particularly suitable for the pediatric age group.
Conclusion: Treatment of fingertip amputations with semi-occlusive foil dressings offers several advantages in childhood. Regular patient follow-up and cooperation from both the child and the parents are essential prerequisites for successful treatment
Fingertip traumatic amputations in children. Treatment with semiocclusive foil dressings-preliminary results
No full textIntroduction: Traumatic fingertip amputations in childhood constitute 2% of all hand injuries in individuals under the age of 14. These injuries have a significant impact on the psychological and emotional well-being of both the children and their parents. The treatment is multifactorial, dependent on the severity and location of the injury, and can involve both conservative and surgical approaches.
Materials and Methods: The study involved 6 patients between the ages of 8 and 15 with fingertip amputations of the hand. The average duration of treatment with semi-occlusive dressings was between 3-4 weeks. The dressing was changed once a week, and after the final dressing, the border between the wound surface and healthy skin was treated with epithelializing ointments.
Results: The average duration of treatment was 20-30 days. On average, dressings were changed 3-5 times throughout the treatment period. After the completion of treatment, the pulp had a normal shape, and the cosmetic outcome was excellent. No contractures were observed in the adjacent joints, and the two-point discrimination test had an average value of 2.5 mm.
Discussion: Fingertip amputations present challenging injuries with multiple available treatment strategies. The presented technique is relatively simple to apply, reduces pain and discomfort, and allows direct visualization of the wound surface without the need for frequent dressing changes. Treatment with semi-occlusive dressings is a minimally invasive method, particularly suitable for the pediatric age group.
Conclusion: Treatment of fingertip amputations with semi-occlusive foil dressings offers several advantages in childhood. Regular patient follow-up and cooperation from both the child and the parents are essential prerequisites for successful treatment
Imperium Militiae(I)
No full textThe most common idea in Romance studies is that Romans, as practical people, didn’t conduct theoretical research on their country or their army, but they gradually built them both. Meanwhile, they reformed and upgraded it, so that they could respond to the challenges of their age. Moreover, the basis of their research was not explicit doctrines, or prior concepts, in fact they used their own, or the experience of others, to find concrete solutions to daily problems. Just as the Hellenic romanophile Polibius (200-120 B.C), in his work Historia, asks the crucial question: ”Is it possible to have such an unreliable man who is not interested in how the Romans, with their unicipal structure, managed to conquer the whole world”? - in the same way the author of this paper, as much as its content allows, humbly and unpretentiously tries to answer the crucial question: “What kind of military structure
created and defended one of the biggest and most enduring empires in world’s history, and what rules governed it”
THE AUTHOR IS ABSENT: TOWARD EMERGENT NARRATIVE EVENT ENVIRONMENTS
No full textCreating an emergent narrative or one which is not predetermined by the controlling figure of the game designer, but instead frees the audience to guide and control the story has been a major interest in the field game design studies of virtual world storytelling. “The Author Is Absent” is an art project that interprets an emergent narrative problem through the prism of performance arts, and mainly the happenings of Alan Kaprow. The following paper provides a theoretical groundwork and some historical examples of previous attempts in the same tradition. It then goes on to elucidate the formal aspects of the work, its mechanics and the results of several attempts at creating an emergent narrative. It traces the creative process that led to the creation of two events – “A Scene about a Drug Deal Gone Wrong” and “The Best Goddamn Art SIU Has to Offer”. Both of them were attempts at creating an environment that could serve as a framework in which an emergent narrative can occur in the interaction between performers and audience. It evaluates the end result of these events and proposes further steps that can be taken towards perfecting the form
HER-2/neu - Molecular Structure and Status. Antibody - Targeted Therapy with Pertuzumab, Trastuzumab and Docetaxel and the Impact on Overall Survival (OS) and Progression-Free Survival (PFS) in Patients with Metastatic Breast Cancer
No full textIntroduction: HER-2 positive breast cancer is one of the most aggressive and rapidly growing neoplasms, due to the amplification and overexpression of the HER-2/neu gene. The exceeding presence of the receptor on the cell`s membrane makes it a valuable treatment target.Materials and Methods: HER-2 receptors are among the main factors controlling the cellular growth, division and self-repair. In approximately 25% of breast cancers, the HER-2 gene mutates, producing too many copies of itself. Several methods are possible for discovering the HER-2 status: immunohistochemistry (IHC) and in situ hybridization (ISH, FISH, CISH, Dual-ISH tests). Positive results on these tests qualify patients for specific antibody-targeted therapy with trastuzumab and pertuzumab. The therapy includes docetaxel combined with trastuzumab or with both trastuzumab and pertuzumab. Scientific studies analyze key aspects such as OS and PFS by conducting double-blind studies comparing pertuzumab+trastuzumab+docetaxel with placebo+trastuzumab+docetaxel. Poll among oncologists was also used to review the efficacy of both treatments.Results: The result of the study, used as reference, showed that the PFS was prolonged by 6.1 months - from 12.4 in the control group to 18.5 in the group, using pertuzumab, instead of placebo. The OS rates improved from 40.8 to 56.6 months - a 15.8 months increase. Distinct side effect of the treatment - left ventricular dysfunction also drops by 3.9% in the pertuzumab group (from 8.3% to 4.4%). Data, gathered from the study, is further validated by the oncologists polled. The results can be explained by delving into the action mechanism of pertuzumab, which blocks heterodimerization of the HER-2 receptor with other members of the ErbB family, thus complementing the effects of trastuzumab.Conclusion: The pertuzumab+trastuzumab+docetaxel treatment shows significantly better results in OS and PFS, as opposed to placebo+trastuzumab+docetaxel, when used as first line of therapy, simultaneously lowering cardiovascular side effects
“THE LONELY SOLDIER OF PREVENTION” (for the book “Enlightenment and Health” and its author)
No full textPresented are articles written in the 1920s and 1930s of the twentieth century, printed in periodic scientific and popular publications (newspapers and medical journals) by Dr. Dimitar Goshev, collected and published in a stand-alone book "Enlightenment and Health" in 2019. Doctor Goshev (1899-1982) studied medicine in Vienna, where he graduated in 1926 and dedicated his life to preventive medicine in the era of dramatic events for the Bulgarian healthcare system
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