1,721,012 research outputs found
The relationship between ozone and human blood in the course of a well-controlled, mild, and transitory oxidative eustress
Full text linkIn the last twenty years there has been a proliferation of articles on the therapeutic use of ozone. As it is well-known, the term ozone therapy is very broad. It ranges from either systemic or loco-regional administration of unstable gaseous oxygen/ozone mixtures to the topical application of stable ozonated derivatives. Anyway, in relation to the absence of specific receptors and the extreme reactivity with the biological liquids with which it comes into contact, gaseous ozone cannot be classified as either a drug or a pro-drug. When the gaseous ozone impacts a biological matrix, both reactive oxygen species (ROS) and lipid oxidation products (LOPs) are formed. They represent the effector molecules responsible for modulating the therapeutic activity in the body. Apart from the merits of the action mechanisms resulting from the use of ozone, this article seeks to validate the practice of ozone therapy as an adjuvant treatment in full compliance with the physiology of the whole organism
Tribological characteristics of glass bottles for pharmaceutical use [Caratteristiche tribologiche dei contenitori primari in vetro per uso farmaceutico]
No full textExperimental comparison tests of different systems for the validation of some parameters of standard and non-standard steam sterilization processes
No full textThe authors have devised a set of steam sterilization tests to investigate to what point the presence of air can alter not only the process, but also the correct control of an industrial sterilization cycle. In addition to the usual autoclave equipment, a control apparatus with special software has been employed. Then, by comparing the results obtained with biological and chemical indicators, F0 detectors with a standard software and with adapted software respectively, it has been possible to estimate how inaccurate some of the present validation methods are. With the data obtained from such test, some trend curves showing the real behaviour of the sterilization parameters have first been plotted, then the mathematical algorithms have been elaborated, allowing us to suggest a new approach for the validation and the management of a sterilization cycle
May oxygen-ozone therapy improves cardiovascular disorders?
No full textIn an aging population vascular disorders well exemplified by the chronic limb ischemia, chronic heart failure, cerebral ischemia and age-related macular degeneration represent a serious medical and socio-economical problem. While there is always a not easily identifiable first pathogenic noxa, all of these diseases are characterized by ischemia, chronic inflammation and tissue degeneration. Orthodox medicine has provided several optimal drugs targeting various pathological situations but, even with their concomitant applications, it is not possible to reduce the chronic oxidative stress. Here it is proposed to associate the approach of ozonated autohemotherapy as a modifier of the biological response capable to block the pathological progress. © Bentham Science Publishers Ltd
The irrationality of a non-specific immunomodulation therapy used in cardiovascular diseases deserves a critical comment
Full text linkTopical applications of ozone and ozonated oils as anti-infective agents: an insight into the patent claims
No full textOrthodox medicine has been very active in the field of topical anti-infective agents and current chemotherapy
has procured valid antibiotics, antivirals, vaccines, antibodies, and antiparasitic drugs to be parenterally and/or topically
used. However, these drugs may cause side effects and sometimes provide unsatisfactory results because pathogens
become drug-resistant. Another drawback is represented by their cost, which compromise their use or their availability in
poor Countries. Therefore, there is a critical need for new strategies to treat dermatological affections. The old intuition
for using ozone in the treatment of necrotic wounds, especially if due to anaerobic bacteria, is now justified by the studies
about reactive oxygen species generation by granulocytes and macrophages as the first line of defense during an infection.
As a consequence, the disinfectant value of ozone has been increasingly appreciated during the last fifteen years. This
review summarizes the patents filed and issued, with particular emphasis to the more recent patents, about the antiinfective
topical use of ozone: i) in the gaseous form; ii) after gaseous ozone saturation of aqueous, not-oily
pharmaceutical vehicles and solvents; iii) where gaseous ozone chemically reacts with unsaturated substrates leading to
therapeutically active ozonated derivatives. We hope that recent advances and a better understanding of the ozone
chemistry and biology will be able to create the mental attitude to prove the validity of large-scale therapeutic use of both
ozone and ozone derivatives as topical anti-infective agents by performing multicenter, randomized clinical studies, as
aptly requested by orthodox medicine
Egg and soya phospholipids, sonication and dialysis: a study onliposome characterization
No full textLiposome-Triton X-100 interactions were studied by turbidity measurements and two detergent concentrations, corresponding to the maximum (i.e., detergent-saturated vesicles; Rsat) and minimum (i.e., completely disruped liposomes; Rsat) turbidity values, were identified. The tested liposomes (SUV) were prepared with phospholipids of different origin (egg and soya) and according to different methods (sonication and dialysis). The data obtained, together with size measurements carried out by electron microscopy, were related to the stability of the vesicles. © 1995
- …
