132,328 research outputs found
Note di possesso di frati francescani in due incunaboli della Biblioteca Fardelliana di Trapani
No full textTwo Franciscan friars from Trapani bearing the same name: Giuseppe Napoli senior and iunior, are described as owners of incunabula (kept today in the local public library, Biblioteca Fardelliana
Frog intestinal sac as an in vitro method for the assessment of intestinal permeability in humans: Application to carrier transported drugs
No full textThe aim of this study was to investigate the presence of pharmaceutically relevant drug transporters in frog intestine which has been proposed as model for intestinal permeability screening assays of passively absorbed drugs in humans [Trapani, G., Franco, M., Trapani, A., Lopedota, A., Latrofa, A., Gallucci, E., Micelli, S., Liso, G., 2004. Frog intestinal sac: a new in vitro method for the assessment of intestinal permeability. J. Pharm. Sci. 93, 2909-2919]. The expression of transporters in frog intestine was supported by the following observations: (i) the involvement of purine nucleobase transport system was deduced by inhibition of acyclovir transport in the presence of adenine; (ii) baclofen or L-dopa transport was inhibited by the digitalis steroid ouabain and it may be related to the Na+ electrochemical potential difference, presumably involving amino acid transporters; (iii) the presence of proton-dependent peptide transporters was argued evaluating the effect of the pH change (from pH 5.9 to pH 7.4) on the transport of glutathione; (iv) the possible expression in the frog intestine of an efflux system distinct from P-glycoprotein (Pgp) in the benzylpenicillin transport was deduced using a glucose enriched frog Ringer with or without the known Pgp inhibitor verapamil; (v) the contribution of Pgp-mediated efflux system in determining the frog intestinal absorption of drugs was supported by the specific inhibition of cimetidine or nadolol transport in the presence of verapamil. These results indicate that pharmaceutically relevant drug transporters should be also expressed in frog intestine. In this work, an attempt was also made to compare the measured P-app values in the frog intestinal model for the aforementioned series of actively/effluxed transported drugs in humans to the corresponding literature values for the fraction absorbed. The P-app values used in these comparisons were obtained at high concentrations of drugs at which probably saturation of the carrier occurs. Interestingly, it was found that drugs that are completely absorbed had P-app values >3 x 10(-6) cm/s, while drugs absorbed <90% had P-app values lower than 1 x 10(-6) cm/s. In these cases, indeed, a borderline region characterized by the apparent permeability coefficient P-app value between 1 x 10(-6) and 3 x 10(-6) cm/s should be considered for which the prediction of the absorbed fraction after oral administration in humans become more uncertain by the frog intestinal sac system. (C) 2007 Elsevier B.V. All rights reserved
La figura e l'attività di Bonaventura Certo, architetto dei Francescani a Trapani nella prima metà del Seicento
No full textIl contributo analizza la biografia e la professione di un protagonista dell'architettura siciliana del primo Seicento. L'attività di Bonaventura Certo, architetto francescano e a servizio presso le sedi isolane dell'ordine (in particolare a Trapani)è indagata attraverso progetti che rivelano un interessante contrubuto per gli sviluppi della storia dell'architettura religiosa siciliana nell'età della Controriforma tra rispetto della tradizione e aggiornamento dedotto dalle opere e dalla stampa del tempo
MR2849476Proskurin, D. On C∗-algebra generated by Fock representation of Wick algebra with braided coefficients. Methods Funct. Anal. Topology 17 (2011), no. 2, 168–173. (Reviewer: Camillo Trapani)
No full textGestione e sviluppo locale
No full textNel saggio curato da Ferdinando Trapani affronta aspetti che legano il problema della gestione turistica delle risorse locali dal punto di vista della programmazione che della pianificazione dello sviluppo territoriale. Il contributo di Ferdinando Trapani affronta una riflessione sulla problematica della gestione nel rapporto tra domanda e offerta turistica
Enzyme controlled release of celecoxib from inulin based nanomicelles
No full textCelecoxib (CLX) delivery and its enzyme-sensitive release from Inulin-d-alfa-tocopherol succinate (INVITE) nanomi-
celles are the main goals of this paper. CLX is a highly hydrophobic drug belonging to BCS class II (low solubility, high
permeability). For this reason its formulation is problematic and its biopharmaceutical performances strongly depend from
the applied delivery system. In the last years, INVITE nanomicelles has been shown their potential in the delivery of highly
hydrophobic drugs such as curcumin and for this reason have been chosen as a good candidate for CLX delivery. Furthermore,
due to the presence of ester bonds between INU and VITE it has been supposed that the drug release could show enzyme-sensitive
(esterase) behaviors. Thus CLX was loaded in INVITE nanomicelles, the loading was quantified and the physical stability was
evaluated up to 90 days, finally, drug release studies in the presence or in the absence of the specific enzyme esterase were
performed
Vele a tarchia nella veduta barocca della città di Trapani. Le origini di una tipologia velica del Mediterraneo
No full textL'articolo è dedicato allo studio delle barche con vela a tarchia raffigurate in un disegno a penna con la veduta della città di Trapani, di autore ignoto, databile nei primi decenni del XVIII secolo. Viene quindi analizzata la tipologia della vela a tarchia nel XVII-XVIII secolo, con riferimento alle origini antiche e alla continuità in contesto tradizionale.The article deals with the study of boats equipped with sprit sails, depicted in a pen drawing with a view of Trapani city (Sicily), made by an unknown author, datable to the first decades of the 18th century. The typology of the sprit sail in the 17th-18th centuries is analysed, with reference to its ancient origins and continuity within the traditional context in southern Italy and in other mediterranean regions
Exchangeability and irreducible rotational invariance
No full textAbstract. Inthisnoteweprovethatafinitefamily{X1,...,Xd}ofrealr.v.’s that is exchangeable and such that (X1, . . . , Xd) is invariant with respect to a subgroup of SO(d) acting irreducibly, is actually invariant with respect to the action of the full group SO(d). Three immediate consequences are deduced: a characterization of isotropic spherical random eigenfunctions whose Fourier coefficients are exchangeable, an extension of Bernstein’s characterization of the Gaussian and a characterization of the Lebesgue measure on the share
MR2666967 Jäkel, Christian D.; Narnhofer, Heide; Wreszinski, Walter F. On the mixing property for a class of states of relativistic quantum fields. J. Math. Phys. 51 (2010), no. 5, 052703, 12 pp. (Reviewer: Camillo Trapani)
No full textHow to treat lobular cancer in the adjuvant setting?
No full textPURPOSE OF REVIEW: The aim of this review is to understand the clinical decision- making process for the management of patients with early invasive lobular breast cancer (ILC), thereby orienting clinicians across large areas of uncertainties and extrapolations. RECENT FINDINGS: The analysis of the principal evidence on the management of ILC, assessing the role and benefit of systemic treatments in the curative setting, have shed the light on the opportunity to escalate and de-escalate systemic therapies for ILC patients, based on the risk of recurrence and the intrinsic value of the treatments. To refine the selection of the patients most likely to benefit from escalated systemic treatments, the role of genomic tools in ILC has been surveyed. Eventually, an overview of the ongoing clinical studies for early lobular tumors has been extracted. SUMMARY: The review identifies large areas of uncertainties and unmet needs for the management of lobular cancer, urging the implementation of clinical studies appropriately designed, tailoring this subgroup of breast cancer patients. As a distinct biological and clinical entity, areas for improvement have been suggested, to support the formulation of controlled studies and better inform clinical decisions based on quality evidence
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